Rimactane Syrup

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 13 Oct 2025 | 04:22 PM (IST)

Rimactane Syrup is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. It may be used alone or in combination with other medicines to fight serious infections.

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General Information

Contains

Rifampicin (100mg/5ml)

Marketer

Novartis India Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Rimactane Syrup may also be given to people who are carriers (people who are infected, yet do not show any signs and symptoms of infection). It should be taken on an empty stomach, at least 30 minutes before a meal or 2 hours after a meal. It should be taken in the dose and duration as advised by the doctor. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.

Some people may develop side effects like low blood platelets, headache, dizziness, vomiting, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away.

Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests for liver function tests while using this medicine.

Uses of Rimactane Syrup

Tuberculosis (TB)

Benefits of Rimactane Syrup

Tuberculosis (TB)
Rimactane Syrup is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Rimactane Syrup

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Rimactane

Dizziness
Paradoxical reactions
Increased aspartate aminotransferase
Increased alanine aminotransferase
Increased bilirubin in the blood
Low blood platelets
Vomiting
Nausea
Fever
Abdominal pain
Skin rash
Hepatitis (viral infection of liver)
Headache
Chills

How to use Rimactane Syrup

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Rimactane Syrup is to be taken empty stomach.

How Rimactane Syrup works

Rimactane Syrup is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Quick tips

Your doctor has prescribed Rimactane Syrup to cure your infection and improve symptoms.
It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food.
Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
Tell your doctor about all other medicines you are taking as Rimactane Syrup can interact with many medicines.
Avoid taking hormone-based birth control methods as Rimactane Syrup may decrease their effectiveness.
Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Rimactane Syrup.

Pregnancy

CONSULT YOUR DOCTOR

Rimactane Syrup may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Rimactane Syrup is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Rimactane Syrup may cause side effects which could affect your ability to drive.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.

Kidney

CAUTION

Rimactane Syrup should be used with caution in patients with kidney disease. Dose adjustment of Rimactane Syrup may be needed. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Rimactane Syrup in patients with liver disease. Please consult your doctor.

Interaction with drugs

Taking Rimactane with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Ticagrelor (Oral Route)

Do not consume Ticagrelor with Rifampicin. Rifampicin may reduce blood levels of Ticagrelor.

Severe

Ranolazine (Oral Route)

Do not consume Ranolazine with Rifampicin. Rifampicin may reduce blood levels and efficacy of Ranolazine.

Severe

Nevirapine (Oral Route)

Do not consume Nevirapine with Rifampicin. Rifampicin may reduce blood levels and efficacy of Nevirapine.

Severe

Voriconazole (Oral Route)

Do not consume Voriconazole with Rifampicin. Rifampicin may reduce blood levels of Voriconazole.

Severe

Bortezomib (Injection Route)

Avoid concurrent use. Please consult with your doctor. Rifampicin may reduce the efficacy of Bortezomib.

Frequently asked questions

Is rifampin a penicillin/amoxicillin/sulfa drug?

No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Is rifampin bacteriostatic or bactericidal?

Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Is rifampin an inducer or inhibitor?

Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

What is R-cin 600 used for?

R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

What is R-cinex/Macox plus/R-cinex 600?

R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Does rifampin cause headaches?

Yes. Headache is a possible side effect of rifampin

Does rifampin change urine color/turn urine orange?

Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Does rifampin cause liver damage?

Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

RNA polymerase inhibitors- Rifamycins

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1213-14.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Vendor Details

Country of origin: India

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Why we need a prescription?

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Rimactane Syrup

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Rimactane Syrup

Benefits of Rimactane Syrup

Side effects of Rimactane Syrup

How to use Rimactane Syrup

How Rimactane Syrup works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ticagrelor (Oral Route)

Ranolazine (Oral Route)

Nevirapine (Oral Route)

Voriconazole (Oral Route)

Bortezomib (Injection Route)

Frequently asked questions

Is rifampin a penicillin/amoxicillin/sulfa drug?

Is rifampin bacteriostatic or bactericidal?

Is rifampin an inducer or inhibitor?

What is R-cin 600 used for?

What is R-cinex/Macox plus/R-cinex 600?

Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

Does rifampin cause headaches?

Does rifampin change urine color/turn urine orange?

Does rifampin cause liver damage?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests