Rapamune 1mg Tablet

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 14 Nov 2025 | 02:10 PM (IST)

Rapamune 1mg Tablet is used for prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ.

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Sirolimus (1mg)

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General Information

Contains

Sirolimus (1mg)

Marketer

Pfizer Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Rapamune 1mg Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body.

Common side effects of this medicine include edema, increased blood lipid level, high blood pressure, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and thrombocytopenia. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions such as rash, shortness of breath, coughing, swelling, etc.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. If you notice signs of infection, any changes in the appearance or size of a mole, unusual growths or lumps, or unusual tiredness or weakness during the treatment, you must consult the doctor immediately.

Uses of Rapamune Tablet

Prevention of kidney transplant rejection

Benefits of Rapamune Tablet

Prevention of kidney transplant rejection
Rapamune 1mg Tablet is used to help prevent the body from rejecting a newly transplanted kidney. It supports long-term transplant success by suppressing the immune response, reducing the risk of organ rejection, and promoting stable kidney function.

Side effects of Rapamune Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Rapamune

Edema (swelling)
Stomatitis (Inflammation of the mouth)
Non-melanoma skin cancer
Hemolytic uremic syndrome
Hypersensitivity
Pericardial effusion
Venous thrombosis
Pulmonary embolism
Pneumonitis
Pleural effusion
Nosebleeds
Pancreatic inflammation
Ascites (accumulation of fluid in the abdominal cavity)
Osteonecrosis (reduced blood flow to the bones)
Ovarian cysts
Joint pain
Increased blood lipid level
Decreased white blood cell count (neutrophils)
Herpes zoster
Sepsis
Kidney infection
Cytomegalovirus infection

How to use Rapamune Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rapamune 1mg Tablet may be taken with or without food.

How Rapamune Tablet works

Rapamune 1mg Tablet is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

All substitutes for Rapamune 1mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Rapamune 1mg Tablet is used to prevent organ rejection following a kidney transplant operation.
Avoid grapefruit juice while you are on treatment with this medicine. This is because a chemical in grapefruit juice increases the amount of Rapamune 1mg Tablet in your bloodstream. This makes side-effects more likely.
There is a possibility of a slight increase in the risk of skin cancer with Rapamune 1mg Tablet. Do not use sunbeds, and avoid strong sunlight or use a sun cream with a high sun protection factor (SPF of at least 15).
If you have diabetes mellitus, this medicine may affect your blood sugar levels. Monitor your sugar level regularly and report any extreme changes to your doctor.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Rapamune 1mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Rapamune 1mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Rapamune 1mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

SAFE

Rapamune 1mg Tablet does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Rapamune 1mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CAUTION

Rapamune 1mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Dose adjustment is not recommended in patients with mild to moderate liver disease.

Interaction with drugs

Taking Rapamune with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Sirolimus or for up to 6 months after stopping Sirolimus.

Life-threatening

Natalizumab (Injection Route)

Do not consume Natalizumab with Sirolimus.

Severe

Carbamazepine (Oral Route)

Do not consume Sirolimus with Carbamazepine. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Carbamazepine may reduce blood levels of Sirolimus.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Cholera Vaccine (Inactivated) should not be used while undergoing treatment with Sirolimus or for up to 6 months after stopping Sirolimus.

Severe

Conivaptan (Injection Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Conivaptan may raise blood levels of Sirolimus.

Frequently asked questions

What is Rapamune 1mg Tablet used for?

Rapamune 1mg Tablet is used to prevent organ rejection in people who have had a kidney transplant. It helps the immune system to avoid attacking the transplanted kidney by lowering the body’s immune response.

Can Rapamune 1mg Tablet cause serious side effects?

Yes, Rapamune 1mg Tablet can cause serious side effects, including lung problems, delayed wound healing, infections, kidney issues, or an increased risk of certain cancers like lymphoma or skin cancer. You should seek medical help if you notice breathing problems, fever, or unusual swelling.

Who should not take Rapamune 1mg Tablet?

Individuals should not take Rapamune 1mg Tablet if they are allergic to it or any of its ingredients. It may also not be suitable if they have certain liver conditions or if they are taking specific medications that interact with sirolimus (medicine present in Rapamune 1mg Tablet).

Can I take sirolimus with other medications?

Sirolimus can interact with many other medications, especially those that affect the liver, immune system, or cholesterol levels. It is important to tell your doctor about all medicines, supplements, or herbal products you use.

Can Rapamune 1mg Tablet increase the risk of infection or cancer?

Yes, because Rapamune 1mg Tablet weakens the immune system, it may increase your risk of infections or certain cancers, especially skin cancer or lymphoma. You should avoid exposure to people with contagious illnesses and protect your skin from sun exposure.

What precautions should I take while on Rapamune 1mg Tablet therapy?

While taking Rapamune 1mg Tablet, you should avoid live vaccines, limit your exposure to sunlight, and have regular blood tests to check your medicine levels, kidney function, cholesterol, and white blood cell count. Inform your doctor immediately if you notice signs of infection or unusual bruising.

Fact Box

Chemical Class

Macrolide lactams

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors

References

Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1012-13.
Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 972-73.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1267-68.
Sirolimus. Sandwich, Kent: Pfizer Limited; 2001 [revised Oct. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
Sirolimus. Philadelphia, Pennsylvania: Wyeth Pharmaceuticals Inc; 1999. [Accessed 06 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:
Sirolimus [Product Description]. Ahmedabad, Gujarat: La Renon Heathcare Pvt. Ltd. [Accessed 06 Apr. 2024] (online) Available from:
Sirolimus [Product Description].Morgantown, WV: Greenstone LLC.; 2024 [Accessed 14 Nov. 2025] (online). Available from:

User feedback

What are you using Rapamune Tablet for?

Prevention of kidney transplant rejection

100%

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Rapamune 1mg Tablet?

Nausea

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Rapamune 1mg Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Rapamune Tablet

Benefits of Rapamune Tablet

Side effects of Rapamune Tablet

How to use Rapamune Tablet

How Rapamune Tablet works

All substitutes for Rapamune 1mg Tablet

Siromus 1mg Tablet

Siropan 1mg Tablet

RAPACan 1mg Tablet

Sirova 1mg Tablet

Sirotor Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Natalizumab (Injection Route)

Carbamazepine (Oral Route)

Cholera Vaccine (Inactivated) (Oral Route)

Conivaptan (Injection Route)

Frequently asked questions

What is Rapamune 1mg Tablet used for?

Can Rapamune 1mg Tablet cause serious side effects?

Who should not take Rapamune 1mg Tablet?

Can I take sirolimus with other medications?

Can Rapamune 1mg Tablet increase the risk of infection or cancer?

What precautions should I take while on Rapamune 1mg Tablet therapy?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Rapamune Tablet for?

How much was the improvement?

What were the side-effects while using Rapamune 1mg Tablet?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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