Sirolimus

Written By Dr. Anuj Saini

Reviewed By Dr. Rajeev Sharma

Last updated 27 May 2025 | 10:06 AM (UTC)

Sirolimus Uses

Sirolimus is used for prevention of kidney transplant rejection.

How Sirolimus works

Sirolimus is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

Common side effects of Sirolimus

Herpes zoster, Stomatitis (Inflammation of the mouth), Sepsis, Kidney infection, Cytomegalovirus infection, Non-melanoma skin cancer, Hemolytic uremic syndrome, Decreased white blood cell count (neutrophils), Hypersensitivity, Pericardial effusion, Venous thrombosis, Pulmonary embolism, Pneumonitis, Pleural effusion, Nosebleeds, Pancreatic inflammation, Ascites (accumulation of fluid in the abdominal cavity), Osteonecrosis (reduced blood flow to the bones), Ovarian cysts

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Medicine brands for Sirolimus

Panacea Biotec Pharma Ltd

₹2159 to ₹2159

1 variant(s)

ROCAS

Emcure Pharmaceuticals Ltd

₹720 to ₹720

1 variant(s)

RAPACan

Eris Lifesciences Ltd

₹2428 to ₹2859

2 variant(s)

Sirova

Intas Pharmaceuticals Ltd

Emcure Pharmaceuticals Ltd

₹1200 to ₹1200

1 variant(s)

Rapasim

Alniche Life Sciences Pvt Ltd

₹1386 to ₹1386

1 variant(s)

Siroglob

Globela Pharma Pvt Ltd

₹66 to ₹66

1 variant(s)

Expert advice for Sirolimus

You may be frequently monitored for renal function during concomitant administration of sirolimus and ciclosporin.
Sirolimus increase risk of infection and the risk of developing certain types of cancer (e.g., lymphoma, skin cancer). Seek immediate medical attention if you notice signs of infection (e.g., persistent sore throat, chills, and fever), any changes in the appearance or size of a mole, night sweats, unusual growths or lumps, or unusual tiredness or weakness.
Avoid use of live vaccines during treatment as the vaccination may be less effective when taking sirolimus.
Use effective methods of contraception during sirolimus therapy and for 12 weeks after sirolimus has been stopped.
Consult your doctor if you develop any liver problems, kidney problems, high cholesterol or triglycerides, low blood platelet levels, diabetes or high blood sugar, or lung or breathing problems or if you are considered to be at high risk for rejection, such as if you had a previous transplant that was lost to rejection.
Limit the exposure to sunlight and UV light by covering your skin with clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer, when receiving sirolimus.
Take sirolimus at the same time in relation to ciclosporin, and consistently with or without food, as its blood levels will be monitored.