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    Sirolimus

    Information about Sirolimus

    Sirolimus uses

    Sirolimus is used in transplant rejection of kidney.

    How sirolimus works

    Sirolimus suppresses the activity of body's immune system and prevents rejection of the transplanted organ.

    Common side effects of sirolimus

    Nausea, Headache, Abdominal pain, Viral infection, Pneumonia, Reduced blood platelets, Increased heart rate, Decreased white blood cell count, Anemia, Urinary tract infection, Diarrhoea, Increased blood pressure, Bacterial infection, Fungal infection, Constipation, Herpes virus infection

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    Expert advice for Sirolimus

    • You may be frequently monitored for renal function during concomitant administration of sirolimus and ciclosporin.
    • Sirolimus increase risk of infection and the risk of developing certain types of cancer (e.g., lymphoma, skin cancer). Seek immediate medical attention if you notice signs of infection (e.g., persistent sore throat, chills, and fever), any changes in the appearance or size of a mole, night sweats, unusual growths or lumps, or unusual tiredness or weakness.
    • Avoid use of live vaccines during treatment as the vaccination may be less effective when taking sirolimus.
    • Use effective methods of contraception during sirolimus therapy and for 12 weeks after sirolimus has been stopped.
    • Consult your doctor if you develop any liver problems, kidney problems, high cholesterol or triglycerides, low blood platelet levels, diabetes or high blood sugar, or lung or breathing problems or if you are considered to be at high risk for rejection, such as if you had a previous transplant that was lost to rejection.
    • Limit the exposure to sunlight and UV light by covering your skin with clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer, when receiving sirolimus.
    • Take sirolimus at the same time in relation to ciclosporin, and consistently with or without food, as its blood levels will be monitored.

    Frequently asked questions for Sirolimus

    Sirolimus

    Q. Is Sirolimus dialyzable?
    Sirolimus is not dialyzable to significant extent. i.e. it will not be eliminated after dialysis.
    Q. Is Sirolimus a calcineurin inhibitor?
    Sirolimus is not a calcineurin inhibitor, but it has a similar suppressive effect on the immune system
    Q. Is Sirolimus cytotoxic?
    Sirolimus is a cytotoxic agent
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    Q. What is Sirolimus-eluting stent?
    The Sirolimus-eluting stent is a metal stent coated with 140 µg/cm2 of Sirolimus blended with synthetic polymers. After stent implantation, Sirolimus is slowly released causing localized inhibition of growth of smooth muscle cells in the wall of the blood vessel in which it is implanted over a period of about 1 month
    Q. Does Sirolimus cause hair loss?
    Sirolimus causes hair loss
    Q. Why does Sirolimus cause hyperlipidemia?
    Sirolimus alters certain body pathways to increase lipid/fat synthesis by the liver, thereby causing hyperlipidemia.

    Content on this page was last updated on 13 October, 2017, by Dr. Varun Gupta (MD Pharmacology)