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Sirolimus

INFORMATION

Uses

Sirolimus is used in transplant rejection of kidney.

How it works

Sirolimus belongs to the class of medication called immunosupressants. It suppresses the body’s immune system and prevents the body from rejecting the transplanted organs.

Common side effects

Herpes infection, Tuberculosis, Bacterial infection, Viral infection

AVAILABLE MEDICINE

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Expert advice

  • You may be frequently monitored for renal function during concomitant administration of sirolimus and ciclosporin.
  • Sirolimus increase risk of infection and the risk of developing certain types of cancer (e.g., lymphoma, skin cancer). Seek immediate medical attention if you notice signs of infection (e.g., persistent sore throat, chills, and fever), any changes in the appearance or size of a mole, night sweats, unusual growths or lumps, or unusual tiredness or weakness.
  • Avoid use of live vaccines during treatment as the vaccination may be less effective when taking sirolimus.
  • Use effective methods of contraception during sirolimus therapy and for 12 weeks after sirolimus has been stopped.
  • Consult your doctor if you develop any liver problems, kidney problems, high cholesterol or triglycerides, low blood platelet levels, diabetes or high blood sugar, or lung or breathing problems or if you are considered to be at high risk for rejection, such as if you had a previous transplant that was lost to rejection.
  • Limit the exposure to sunlight and UV light by covering your skin with clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer, when receiving sirolimus.
  • Take sirolimus at the same time in relation to ciclosporin, and consistently with or without food, as its blood levels will be monitored.

Frequently asked questions

Sirolimus

Q.Is sirolimus dialyzable?
Sirolimus is not dialyzable to significant extent. i.e. it will not be eliminated after dialysis.

Q.Is sirolimus a calcineurin inhibitor?
Sirolimus is not a calcineurin inhibitor, but it has a similar suppressive effect on the immune system

Q.Is sirolimus cytotoxic?
Sirolimus is a cytotoxic agent

Q.What is sirolimus-eluting stent?
The sirolimus-eluting stent is a metal stent coated with 140 µg/cm2 of sirolimus blended with synthetic polymers. After stent implantation, sirolimus is slowly released causing localized inhibition of growth of smooth muscle cells in the wall of the blood vessel in which it is implanted over a period of about 1 month

Q.Does sirolimus cause hair loss?
Sirolimus causes hair loss

Q.Why does sirolimus cause hyperlipidemia?
Sirolimus alters certain body pathways to increase lipid/fat synthesis by the liver, thereby causing hyperlipidemia.


Content on this page was last updated on 11 November, 2016, by Dr. Varun Gupta (MD Pharmacology)