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MD (Pharmacology), MBBS
Last updated
29 Jun 2022 | 05:40 PM (IST)

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Siromus 1mg Tablet

Prescription Required
Manufacturer
SALT COMPOSITION
Storage
Store below 30°C
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Product introduction

Siromus 1mg Tablet is used for prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ.

Siromus 1mg Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body.

Common side effects of this medicine include edema, increased blood lipid level, high blood pressure, increased level of creatinine, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and thrombocytopenia. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions such as rash, shortness of breath, coughing, swelling, etc.

Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. If you notice signs of infection, any changes in the appearance or size of a mole, unusual growths or lumps, or unusual tiredness or weakness during the treatment, you must consult the doctor immediately.

Uses of Siromus Tablet

  • Prevention of kidney transplant rejection

Benefits of Siromus Tablet

In Prevention of kidney transplant rejection

Siromus 1mg Tablet is used with other medications to prevent kidney transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving kidney transplants. This medicine reduces the activity of a person's own immune system and prevents any such rejection.

Side effects of Siromus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Siromus

  • Nausea
  • Increased blood lipid level
  • Low blood platelets
  • Headache
  • Abdominal pain
  • Fever
  • Anemia (low number of red blood cells)
  • Urinary tract infection
  • Diarrhea
  • High blood pressure
  • Increased creatinine level in blood
  • Joint pain
  • Edema (swelling)

How to use Siromus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siromus 1mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Siromus Tablet works

Siromus 1mg Tablet is an immunosuppressant. It works by suppressing your body’s immune response following transplant of an organ (eg. liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Siromus 1mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Siromus 1mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Siromus 1mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Siromus 1mg Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Siromus 1mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Siromus 1mg Tablet is recommended.
Liver
CAUTION
Siromus 1mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Siromus 1mg Tablet may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild to moderate liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Siromus 1mg Tablet
₹173.64/Tablet
Rocas 1mg Tablet
Emcure Pharmaceuticals Ltd
₹96.17/tablet
45% cheaper
Rapasim 1 Tablet
Alniche Life Sciences Pvt Ltd
₹111.6/tablet
36% cheaper
Rapolax 1mg Tablet
Taj Pharma India Ltd
₹127.1/tablet
27% cheaper
Emtor 1mg Tablet
Emcure Pharmaceuticals Ltd
₹128.1/tablet
26% cheaper
Limus 1mg Tablet
Claris Lifesciences Ltd
₹136.5/tablet
21% cheaper

Quick tips

  • Siromus 1mg Tablet is used to prevent organ rejection following a kidney transplant operation.
  • Avoid grapefruit juice while you are on treatment with this medicine. This is because a chemical in grapefruit juice increases the amount of Siromus 1mg Tablet in your bloodstream. This makes side-effects more likely.
  • There is a possibility of a slight increase in the risk of skin cancer with Siromus 1mg Tablet. Do not use sunbeds, and avoid strong sunlight or use a sun cream with a high sun protection factor (SPF of at least 15).
  • If you have diabetes mellitus, this medicine may affect your blood sugar levels. Monitor your sugar level regularly and report any extreme changes to your doctor.

Fact Box

Chemical Class
Macrolide Lactams
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Immunosuppressant- mTOR inhibitors

Interaction with drugs

Taking Siromus with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Clarimac, CLR, Claripax
Life-threatening
Brand(s): Arthrox, Ciresto, Eromax
Life-threatening
Brand(s): Rotasiil, Rotarix, RotaTeq
Life-threatening
Life-threatening

Patient concerns

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Heavy Skin Problem With Kidney Transplant Patient
Dr. Souvik Sardar
Dermatology
need a clinical examination of the problem. post clear and focused PICTURES of the problem else visit a dermatologist nearby
Nephrologist considered for consulting Function of kidney transplant patients suffering from tuberculosis
Dr. Praveen Pushkar
Urology
Get kidney function test done
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1012-13.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 972-73.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1267-68.
  4. Drugs.com. Sirolimus. [Accessed 06 Apr. 2019] (online) Available from:External Link
  5. Sirolimus. Sandwich, Kent: Pfizer Limited; 2001 [revised Oct. 2018]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  6. Sirolimus. Philadelphia, Pennsylvania: Wyeth Pharmaceuticals Inc; 1999. [Accessed 06 Apr. 2019] (online) Available from:External Link
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Expires on or after: October, 2023

A licensed vendor partner from your nearest location will deliver Siromus 1mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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