Pryl 50mg Tablet SR

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Introduction

Pryl 50mg Tablet SR is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine.

Pryl 50mg Tablet SR is normally taken before bedtime because it can make you feel sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. The initial dose should be increased with great caution under close supervision. This medicine may not work straight away and it could be several weeks before you get the full effects.
How long you need to use it will depend on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not stop taking the medicine suddenly without talking to your doctor. Stopping the medicine suddenly can worsen your conditions or cause other symptoms. Your dose may be modified or gradually decreased before stopping the medication.

The most common side effects of this medicine include nausea, constipation, sweating, dry mouth, sleepiness, tremor, dizziness, headache, speech disorder, accommodation disorder, palpitations, increased heart rate, orthostatic hypotension, and nasal congestion. It may also make you aggressive or confused and can lead to weight gain in some people. This medicine is not addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. Most of the common side effects tend to be mild. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.

Benefits of Pryl Tablet SR

In Depression

Pryl 50mg Tablet SR works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of well-being, relieve anxiety and tension, helps you sleep better, and increase your energy level. Pryl 50mg Tablet SR is readily absorbed and starts action within approximately 6 hours of taking it orally (by mouth). It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

In Neuropathic pain

Pryl 50mg Tablet SR helps in relieving neuropathic pain caused by nerve damage in certain conditions. These may include painful diabetic neuropathy, post-herpetic neuralgia, or spinal cord disease. It works by affecting chemicals in the brain called neurotransmitters. By relieving pain, it helps improve your quality of life.

In Migraine

Pryl 50mg Tablet SR helps prevent migraines by changing the way that your nerves receive pain signals. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

Side effects of Pryl Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pryl

  • Constipation
  • Dryness in mouth
  • Increased heart rate
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Weight gain
  • Aggressive behavior
  • Nasal congestion (stuffy nose)
  • Sleepiness
  • Sweating
  • Dizziness
  • Headache
  • Nausea
  • Tremor
  • Speech disorder
  • Accomodation disorder
  • Palpitations
  • Decreased libido
  • Difficulty in paying attention

How to use Pryl Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pryl 50mg Tablet SR may be taken with or without food, but it is better to take it at a fixed time.

How Pryl Tablet SR works

Pryl 50mg Tablet SR contains Amitriptyline, a tricyclic antidepressant. It has anticholinergic and sedative properties. It prevents the reuptake, and hence the inactivation of neurotransmitters called noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Pryl 50mg Tablet SR.
Pregnancy
CONSULT YOUR DOCTOR
Pryl 50mg Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Pryl 50mg Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Pryl 50mg Tablet SR may cause side effects which could affect your ability to drive.
Pryl 50mg Tablet SR may impair your alertness which may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Pryl 50mg Tablet SR is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Pryl 50mg Tablet SR may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Pryl 50mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Pryl 50mg Tablet SR may be needed. Please consult your doctor.
Use of Pryl 50mg Tablet SR is not recommended in patients with severe liver disease.

What if you forget to take Pryl Tablet SR?

If you miss a dose of Pryl 50mg Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Pryl 50mg Tablet SR
₹5.02/Tablet SR
Goldep 50mg Tablet SR
Glenmark Pharmaceuticals Ltd
₹3.03/Tablet SR
40% cheaper
Aldep 50mg Tablet SR
Altius Life Sciences
₹3.86/Tablet SR
23% cheaper
₹4.5/Tablet SR
10% cheaper
Amitop 50mg Tablet SR
Tas Med India Pvt Ltd
₹5.17/Tablet SR
3% costlier
₹6.8/Tablet SR
35% costlier

Quick Tips

  • It may take 4 to 6 weeks for Pryl 50mg Tablet SR to start working. Keep taking it as prescribed.
  • It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Pryl 50mg Tablet SR as it may cause excessive sleepiness.
  • Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
  • It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.

Fact Box

Chemical Class
Dibenzocycloheptenes Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Tricyclic antidepressants

Interaction with Drugs

Taking Pryl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Lizolan, Lidoford, Zenlid
LIFE-THREATENING
Brand(s): Trima, Rimarex, Morex
LIFE-THREATENING
Brand(s): Moxicheck, Moxonex, Unsym
LIFE-THREATENING

Patient Concerns

arrow
Most of the times when I get excited or have orgasm I feel pain in my testis and around it .
Dr. Pranay Gandhi
Sexology
hi PATIENT neuropathic pain mostly. take tablet emanzen d 1 bd
Sir Plz suggest me effective pain killer with minimum side effects for back pain and arthritis, which can be taken on regular basis as and when required.
Dr. Vikas Sharma
Neurology
dpeneds on the type of pain - muscular or neuropathic; show tro nearby neuro
arrow
Do you have any questions related to Pryl 50mg Tablet SR ?

FAQs

Q. What other lifestyle changes should I make to get maximum benefit of Pryl 50mg Tablet SR?

Antidepressants, including Pryl 50mg Tablet SR, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Pryl 50mg Tablet SR and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.

Q. Is there anything I need to be careful about while on therapy with Pryl 50mg Tablet SR?

Pryl 50mg Tablet SR may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.

Q. Can the use of Pryl 50mg Tablet SR affect my sex life?

Yes, Pryl 50mg Tablet SR can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.

Q. I have been taking Pryl 50mg Tablet SR for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?

You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Pryl 50mg Tablet SR takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Pryl 50mg Tablet SR, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.

Q. Can Pryl 50mg Tablet SR cause urinary problems?

Yes, Pryl 50mg Tablet SR can cause urinary problems. It is more commonly seen in elderly patients who are more than 65 years old. The patient may face difficulty in passing urine which can further lead to a urinary tract infection. Consult your doctor immediately if you develop these symptoms.

Q. If my pain is not relieved, can I take more than the recommended dose?

No, you should use Pryl 50mg Tablet SR strictly as prescribed by the doctor. If the dose exceeds, you may develop drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discoloration of the skin and decreased heartbeat. Your pain may not be relieved because Pryl 50mg Tablet SR takes about 2 weeks to show its effect, but it may take longer in some cases. The duration of treatment can differ from individual to individual. Consult your doctor if your symptoms are not relieved.

Q. Does Pryl 50mg Tablet SR cause any effect on pregnancy or the newborn?

Do not take Pryl 50mg Tablet SR during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of the pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor drinking, loud crying, difficulty in urinating and constipation.

Q. I have been prescribed Pryl 50mg Tablet SR for pain. When will I start feeling better?

You may start feeling better after 2 weeks of starting Pryl 50mg Tablet SR. However, it may take 4-6 weeks to see the full benefits of the medicine.

Q. Can I stop taking Pryl 50mg Tablet SR when my pain is relieved?

No, do not stop taking Pryl 50mg Tablet SR even if the pain is relieved. You should use Pryl 50mg Tablet SR as advised by the doctor. Stopping the medicine suddenly may cause unpleasant symptoms like headache, feeling unwell, sleeplessness and irritability. Consult your doctor for the duration of the treatment since the dose of Pryl 50mg Tablet SR needs to be reduced gradually.

Q. How long does Pryl 50mg Tablet SR take to work?

You may see an improvement in your symptoms after a couple of weeks, although it usually takes between 4 and 6 weeks before you feel the benefits. Do not stop taking Pryl 50mg Tablet SR after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.

Q. How will Pryl 50mg Tablet SR make me feel?

Antidepressants like Pryl 50mg Tablet SR help to gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Pryl 50mg Tablet SR will not make you feel excessively or unusually happy. It will help you feel like yourself again.

Related Products

Related Ayurvedic Ingredients

Want to share the information?

Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
  3. Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:External Link
  4. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:External Link
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Cnergy IT Park, 3rd floor Appa Saheb Marathe Marg, Prabhadevi, Mumbai 400025
MRP
50.2
Inclusive of all taxes
10 tablet sr in 1 strip
SOLD OUT

INDIA’S LARGEST HEALTHCARE PLATFORM

160M+
Visitors
27M+
Orders Delivered
1800+
Cities
Get the link to download App
Reliable

All products displayed on 1mg are procured from verified and licensed pharmacies. All labs listed on the platform are accredited

Secure

1mg uses Secure Sockets Layer (SSL) 128-bit encryption and is Payment Card Industry Data Security Standard (PCI DSS) compliant

Affordable

Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations.

India's only LegitScript and ISO/IEC 27001 certified online healthcare platform

Know More About 1mgdownArrow

Access medical and health information

1mg provides you with medical information which is curated, written and verified by experts, accurate and trustworthy. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies.

Order medicines online

Get free medicine home delivery in over 1800 cities across India. You can also order Ayurvedic, Homeopathic and other Over-The-Counter (OTC) health products. Your safety is our top priority. All products displayed on 1mg are procured from verified and licensed pharmacies.

Book lab tests

Book any lab tests and preventive health packages from certified labs and get tested from the comfort of your home. Enjoy free home sample collection, view reports online and consult a doctor online for free.

Consult a doctor online

Got a health query? Consult doctors online from the comfort of your home for free. Chat privately with our registered medical specialists to connect directly with verified doctors. Your privacy is guaranteed.