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Prothymo 450mg Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 14 Apr 2026 | 01:31 PM (IST)
Prothymo 450mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor.
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General Information

The content is shown in English
Prothymo 450mg Tablet image
Prothymo 450mg Tablet image

Product introduction

Prothymo 450mg Tablet should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken with food. You should drink plenty of water while on treatment with this medicine, as it helps prevent dehydration and kidney damage.


Prothymo 450mg Tablet may cause a few common side effects like diarrhea, vomiting, anemia, low white blood cells, low platelet levels, insomnia, and vomiting. Inform your doctor if these side effects persist for a longer duration.


Before you start Prothymo 450mg Tablet, let your doctor know if you have any medical conditions. Let your doctor also know about all the medications you are taking, as some medicines may interact with Prothymo 450mg Tablet. Please consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Uses of Prothymo Tablet

Benefits of Prothymo Tablet

Treatment of Cytomegalovirus Infection
Cytomegalovirus infection is a common virus infection which may have no symptoms at all or may have symptoms like fever and fatigue. Severe infection may show symptoms involving the eyes, brain, or other internal organs. This virus is spread through sexual and nonsexual contact with body secretions in people who are immunocompromised or those who have undergone any transplant. Prothymo 450mg Tablet helps to prevent multiplication of the infection causing virus and treats the infection. Keep taking it in the dose and duration prescribed by the doctor to get maximum benefit.

Side effects of Prothymo Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Prothymo
  • Diarrhea
  • Fever
  • Fatigue
  • Nausea
  • Tremors
  • Decreased white blood cell count (neutrophils)
  • Anemia (low number of red blood cells)
  • Decreased white blood cell count
  • Low blood platelets
  • Headache
  • Insomnia (difficulty in sleeping)
  • Vomiting
  • Urinary tract infection

How to use Prothymo Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prothymo 450mg Tablet should be taken with or after food.

How Prothymo Tablet works

Prothymo 450mg Tablet is an antiviral medication. It prevents the multiplication of viruses in human cells. This stops the virus from producing new viruses and clears up your infection.

Quick tips

  • Take Prothymo 450mg Tablet exactly as prescribed by your doctor to effectively control CMV retinitis and prevent the worsening of the infection.
  • Regular blood tests may be required to monitor your blood cell counts, as Prothymo 450mg Tablet can cause low white blood cells (leukopenia) and low platelets (thrombocytopenia).
  • Inform your doctor if you experience unusual bleeding, persistent fever, vision changes, or severe fatigue, as these may indicate serious side effects.
  • Use effective contraception during treatment and for at least 90 days after stopping the medication, as Prothymo 450mg Tablet may cause birth defects.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Prothymo 450mg Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Prothymo 450mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Prothymo 450mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Prothymo 450mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Prothymo 450mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

SAFE IF PRESCRIBED
Prothymo 450mg Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Prothymo with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Tenofovir disoproxil fumarate (Oral Route)

Concurrent use may increase the risk of kidney damage.
Moderate

Amphotericin B (Injection Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Amphotericin B may slow down the removal of Valganciclovir from the body.
Moderate

Amphotericin B (Vaginal Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Amphotericin B may slow down the removal of Valganciclovir from the body.
Moderate

Cidofovir (Injection Route)

If concurrent use is essential, please consult your doctor. They may monitor your kidney's functioning closely. Cidofovir may slow down the removal of Valganciclovir from the body.

Frequently asked questions

Prothymo 450mg Tablet is used for the treatment of cytomegalovirus (CMV) infection of the retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor.
After being taken orally, Prothymo 450mg Tablet gets converted into ganciclovir by liver and intestinal enzymes, which then prevents the growth and spread of cytomegalovirus.
Prothymo 450mg Tablet can also be used for the treatment of herpes simplex virus (HSV) infection. Please follow the doctor's advice regarding its use.

Fact Box

Chemical Class

Alpha amino acid derivative

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Antiviral Agents (Non-HIV)

References

  1. Acosta EP, Flexner C. Antiviral Agents (Nonretroviral). In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1603-605.
  2. Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 852.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1446-47.
  4. Alganciclovir [Prescribing Information]. South San Francisco, California: Genentech USA; 2010. [Accessed 01 Apr. 2019] (online) Available from:
  5. Valgaciclovir [Prescribing Information]. Piscataway, NJ: Camber Pharmaceuticals, Inc.; 2025. [Accessed 09 Mar. 2025] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sanofi India Ltd
Address: Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072

Vendor Details

Country of origin: India
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