Prostigmin 15mg Tablet

Neostigmine (15mg)

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Prostigmin 15mg Tablet is used in the treatment of myasthenia gravis (a disease-causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), postoperative urinary retention, and reversal of the effect of skeletal muscle relaxants after surgery.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)

₹29.8 MRP ₹33.7512% off

Gurgaon

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General Information

Contains

Neostigmine (15mg)

Marketer

Abbott Healthcare Private Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Prostigmin 15mg Tablet works by reducing and improving muscle weakness. It may be taken with or without food, preferably at the same time each day. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment. You should never stop this medicine suddenly without talking to your doctor.

Some common side effects of using this medication are nausea, vomiting, abdominal cramps, increased production of saliva, and diarrhea. It usually does not cause dizziness and sleepiness. But if you feel ill, avoid doing any such work that requires focus and attention, such as driving or operating any machinery.

Before taking Prostigmin 15mg Tablet, it is better to inform your doctor if you are suffering from any kidney problems, Parkinson's disease, asthma, or stomach disorders. Your blood pressure may decrease after taking this medicine, so it is better to monitor it and consult your doctor if it bothers you. This medicine may cause diarrhea, so drink plenty of fluids to keep yourself hydrated while taking this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Prostigmin Tablet

Treatment of Myasthenia gravis
Treatment of Paralytic ileus
Post-operative urinary retention
Reversal of effect of skeletal muscle relaxant after surgery

Benefits of Prostigmin Tablet

Treatment of Myasthenia gravis
Myasthenia gravis is a neuromuscular disorder that leads to weakness of muscles that are under our control, such as those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. It happens due to impaired coordination between muscles and nerves. Prostigmin 15mg Tablet makes this coordination between nerves and muscles better and relieves the symptoms. As a result, your muscle strength is improved, and you can lead a better life.

Treatment of Paralytic ileus
Prostigmin 15mg Tablet is used in the treatment of paralytic ileus to help restore normal bowel movement when the intestines temporarily stop functioning after surgery or illness. It promotes the movement of contents through the gut. This helps relieve abdominal bloating, discomfort, and constipation associated with reduced intestinal motility, supporting the return of normal digestive function.

Post-operative urinary retention
After an operation, there may be problems in emptying the bladder. This may be due to the disturbed coordination of nerves and muscles of the bladder. Prostigmin 15mg Tablet helps to improve this problem and treats post-operative urinary retention effectively.

Reversal of effect of skeletal muscle relaxant after surgery
Skeletal muscle relaxants are given to induce anesthesia and to carry out surgical or certain diagnostic procedures. This blocks the conduction of signals between nerves and muscles. After the surgery, Prostigmin 15mg Tablet is given to reverse this effect and cause muscle contraction again to restore normal function.

Side effects of Prostigmin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Prostigmin

Increased saliva production
Nausea
Vomiting
Abdominal cramp
Diarrhea

How to use Prostigmin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prostigmin 15mg Tablet may be taken with or without food.

How Prostigmin Tablet works

Prostigmin 15mg Tablet is a reversible cholinesterase inhibitor. When taken by mouth, it increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (an enzyme). This acetylcholine further triggers muscle-contracting receptors, which help in muscle contraction.

All substitutes for Prostigmin 15mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Tilstigmin Tablet

by Tablets India Limited

₹4.71/tablet

58% costlier

Tilistigmin 15mg Tablet

by Tablets India Limited

₹4.3/tablet

44% costlier

Quick tips

You have been prescribed Prostigmin 15mg Tablet for the treatment of myasthenia gravis.
It may also be used to treat inactivity of the muscle in the intestines (paralytic ileus) and difficulty in passing urine (urinary retention) after an operation.
Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
Do not drink alcohol while taking this medicine, as it may worsen the side effects.
Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Prostigmin 15mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Prostigmin 15mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

UNSAFE

Prostigmin 15mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Prostigmin 15mg Tablet may cause side effects that could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Prostigmin 15mg Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine.

Liver

CAUTION

Prostigmin 15mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Prostigmin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Norfloxacin (Oral Route)

Caution is advised when taking Norfloxacin with Neostigmine if you have myasthenia gravis (a chronic autoimmune disorder in which antibodies destroy the communication between nerves and muscle, resulting in weakness of the skeletal muscles). Norfloxacin may increase the side effects of Neostigmine.

Moderate

Rivastigmine (Transdermal Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Neostigmine may increase the effect of Rivastigmine.

Moderate

Thalidomide (Oral Route)

watch out for symptoms such as breathlessness, fatigue, drowsiness, sedation or faintness or vomiting and consult your doctor if you experience them. They may monitor and adjust the doses as per the observations.

Moderate

Donepezil (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Rivastigmine (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Neostigmine may increase the effect of Rivastigmine.

Frequently asked questions

Does Prostigmin 15mg Tablet treat myasthenia gravis? How long do I need to take it?

Prostigmin 15mg Tablet relieves the symptoms of myasthenia gravis but does not cure it. It does so by reducing and improving muscle weakness. The length of time for which you need to take Prostigmin 15mg Tablet will depend on your condition. Do not stop taking Prostigmin 15mg Tablet until and unless advised by your doctor, even if you start feeling better.

How long does Prostigmin 15mg Tablet take to start working?

Prostigmin 15mg Tablet takes about 5 to 15 minutes to start working and remains effective for 2-4 hours.

I felt better when I started taking Prostigmin 15mg Tablet, but I have noticed recently that I get tired easily and quickly. Will increasing the dose help me?

If your symptoms have started reappearing, then it could be due to increased severity of myasthenia gravis or excess dose of Prostigmin 15mg Tablet. Both conditions have similar effects, so it becomes very difficult to differentiate between the two. Do not increase the dose on your own and consult your doctor immediately.

Can I take Prostigmin 15mg Tablet for constipation?

No, Prostigmin 15mg Tablet should not be taken for any type of constipation. However, its use is limited to cases of constipation caused by paralysis of the intestine and strictly on prescription by the doctor.

What should I do if I accidentally take more than the dose required?

You should seek immediate medical help in case of overdose of Prostigmin 15mg Tablet. Excess of Prostigmin 15mg Tablet may cause stomach pain, nausea, vomiting, diarrhea, blurred vision, difficulty in breathing, and excessive sweating, salivation, and weakness. It can even lead to paralysis.

Does Prostigmin 15mg Tablet have any abuse potential?

No, there is no evidence of Prostigmin 15mg Tablet having any abuse potential.

Who should not take Prostigmin 15mg Tablet?

Prostigmin 15mg Tablet should not be taken by patients who are allergic to it. Patients who are constipated or cannot urinate should avoid its use, unless advised by the doctor. This is because Prostigmin 15mg Tablet is only used for certain types of urination problems and constipation (e.g., caused by paralysis of the intestine).

Fact Box

Chemical Class

Phenoxy compounds

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Carbamate-Based Cholinesterase Inhibitors

Related lab tests

Acetyl Choline Receptor Antibody

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 969.
Neostigmine bromide [EMC SmPC]. Chippenham, Wiltshire: Alliance Pharmaceuticals; 2015. [Accessed 28 Jan. 2019] (online) Available from:
Neostigmine [EMC SmPC]. Swinton, Manchester: Pharmaserve Limited; 2015. [Accessed 25 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Neostigmine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
Neostigmine [Summary of Product Characteristics]. Bucharest, Romania: Labormed Pharma S.A.; 2014.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott Healthcare Private Limited
Address: Regd. Office 3 Corporate Park, Sion-Trombay Road, Mumbai- 400071, India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Prostigmin 15mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Prostigmin Tablet

Benefits of Prostigmin Tablet

Side effects of Prostigmin Tablet

How to use Prostigmin Tablet

How Prostigmin Tablet works

All substitutes for Prostigmin 15mg Tablet

Tilstigmin Tablet

Tilistigmin 15mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Norfloxacin (Oral Route)

Rivastigmine (Transdermal Route)

Thalidomide (Oral Route)

Donepezil (Oral Route)

Rivastigmine (Oral Route)

Frequently asked questions

Does Prostigmin 15mg Tablet treat myasthenia gravis? How long do I need to take it?

How long does Prostigmin 15mg Tablet take to start working?

I felt better when I started taking Prostigmin 15mg Tablet, but I have noticed recently that I get tired easily and quickly. Will increasing the dose help me?

Can I take Prostigmin 15mg Tablet for constipation?

What should I do if I accidentally take more than the dose required?

Does Prostigmin 15mg Tablet have any abuse potential?

Who should not take Prostigmin 15mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Acetyl Choline Receptor Antibody

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests