AChR (Acetyl Choline Receptor) Antibodies

Acetylcholine is a neurotransmitter that is responsible for initiating muscle contraction by sending signals from nerves to muscles. In individuals with myasthenia gravis (MG), the immune system creates abnormal proteins called acetylcholine receptor antibodies, which interfere with normal acetylcholine function. MG is an autoimmune disorder, since the body mistakenly attacks its own communication networks between muscles and nerves, leading to fluctuating muscle weakness.

Although MG is rare, it can affect individuals of any age. Most individuals with MG have a normal life span, but require treatment to control its debilitating symptoms, such as shortness of breath, trouble speaking, drooping eyelids, unsteady walk, and weakness in the arms, legs, neck, and fingers.

Doctors may suggest the AChR (Acetyl Choline Receptor) Antibodies test when there is a suspicion of MG. Early symptoms may range from problems with breathing muscles to weakness of muscles throughout the body. The most common symptoms are weakness in muscles that control eye and eyelid motion, as seen in ocular MG, facial expression, chewing, swallowing, talking, and arm and leg motion.

The patient must discontinue muscle relaxants and anesthetics for 24 hours prior to sample collection, as these drugs may affect the test results. It is important to inform the doctor about all medications (e.g., immunosuppressants, supplements) currently being taken, as some of them may affect the test results, potentially requiring dosage adjustments or temporary discontinuation before the test.

Test result ranges are approximate and may differ slightly between laboratories depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.