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Norfloxacin is used in the treatment of adults with urinary tract infections, both uncomplicated (cystitis) and complicated urinary tract infections, sexually transmitted diseases (gonorrhea), genital infection, prostate infection (prostatitis), infections of the stomach or intestines (travelers’ diarrhea) and eye infection. It acts by inhibiting bacterial deoxyribonucleic acid synthesis and thus, killing the bacteria.

How it works

Norfloxacin belongs to class of drugs called flouroquinolone antibiotics. Norfloxacin inhibits bacterial reproduction by inhibiting DNA formation, thereby killing the bacteria.

Common side effects

Decreased urination, Facial swelling, Allergic reaction, Lip swelling, Skin rash, Itching, Urticaria, Shortness of breath, Anxiety, Muscle pain, Joint pain, Bruise, Bleeding, Blisters on skin, Convulsion, Dark colored urine, Dizziness, Diarrhoea, Headache, Hoarseness of voice, Loss of consciousness, Fainting, Restlessness, Stomach cramp, Tachycardia, Tremor, Uncoordinated body movements, Vomiting, Abdominal pain, Yellow discoloration of skin, Yellow discoloration of eye, Weakness, Fever, Confusion, Hallucination, Heartburn, Nausea


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Expert advice

  • Avoid  norfloxacin if you have  known history of muscle weakness (myasthenia gravis). It may further increase the muscle weakness.
  • Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate -may increase nervousness, sleeplessness, heart pounding, and anxiety.
  • Drink plenty of water or other fluids every day while you are taking norfloxacin.
  • Do not start or continue the norfloxacin and consult your doctor if you have allergies to medicines, foods, or other substances.
  • Avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Norfloxacin may make your skin sensitive to sunlight or ultraviolet light. If your skin becomes reddened, swollen, or blistered, consult your doctor.
  • Take norfloxacin at least one hour before or at least two hours after taking antacids (aluminum or magnesium hydroxide), didanosine, sucralfate, supplements or multivitamins that contain iron or zinc, meal or ingestion of milk and/or other dairy products. 
  • Norfloxacin can cause dizziness and light-headedness and, therefore, caution has to be taken before operating an automobile or machinery or engaging in activities requiring mental alertness and coordination.
  • Norfloxacin is associated with an increased risk of tendinitis and tendon rupture. it should be used carefully in patients over 60 years of age, in patients taking steroids corticosteroid drugs, in patients with kidney, heart or lung transplants to minimize this risk.

Frequently asked questions


Q. Is norfloxacin/ norflox tz/ norflox 400/ norilet/ norilet 400 same as ciprofloxacin?
No, however they belong to same class of medication called as fluoroquinolones and act by same mechanism but differ in absorption, metabolism and excretion.
Q. Is norfloxacin/ norflox tz/ norflox 400/ norilet/ norilet 400 same as penicillin/broad spectrum antibiotic?
No, they belong to same class of medication called as fluoroquinolones and they act by different mechanism.
 Q. Is norfloxacin/ norflox tz/ norflox 400/ norilet/ norilet 400 used for treatment of diarrhea and UTI?
Yes, however it depends on microorganism involved and effectiveness. Always consult your doctor on this regards.
Q. Is norfloxacin sulfa based / a penicillin/ an antibiotic?
No. Norfloxacin belong to a different group of antibiotics called fluoroquinolones. It does not contain penicillin or sulpha.

Content on this page was last updated on 17 October, 2016, by Dr. Varun Gupta (MD Pharmacology)