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Plepon 6 Tablet ER

Paliperidone (6mg)
Genuine
Authenticity Assured
Prescription
required
Plepon 6 Tablet ER is used to treat schizophrenia and mania. It works by helping to restore the balance of certain natural chemicals in the brain, which improves mood, thinking, and behavior, and reduces symptoms like hallucinations or delusions.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
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10 tablet er
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General Information

The content is shown in English
Plepon 6 Tablet ER image
Plepon 6 Tablet ER image
Plepon 6 Tablet ER image
Plepon 6 Tablet ER image
Plepon 6 Tablet ER image

Product introduction

Plepon 6 Tablet ER may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience Neuroleptic malignant syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness.


Some common side effects of this medicine include drowsiness, anxiety, increased heart rate and tremor. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.


You should be cautious if you are using this medicine as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.

Uses of Plepon Tablet ER

Benefits of Plepon Tablet ER

Mania
Mania means extremely excited or elevated mood. Plepon 6 Tablet ER helps calm the mood and relax the nerves. This stabilises the mood and prevents the symptoms of mania from recurring again. Taking Plepon 6 Tablet ER will ensure that you have a better social life and are able to do daily activities more comfortably.

Side effects of Plepon Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Plepon
  • Abnormal involuntary movements
  • Dizziness
  • Injection site reactions (pain, swelling, redness)
  • Nystagmus (involuntary eye movement)
  • Sleepiness
  • Tremors
  • Cogwheel rigidity
  • Nasopharyngitis (inflammation of the throat and nasal passages)

How to use Plepon Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Plepon 6 Tablet ER may be taken with or without food.

How Plepon Tablet ER works

Plepon 6 Tablet ER is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts and behavior.

All substitutes for Plepon 6 Tablet ER

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Take it in the morning, preferably at the same time every day.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Use caution while driving or doing anything that requires concentration as Plepon 6 Tablet ER can cause dizziness and sleepiness.
  • It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly.
  • Monitor your blood sugar regularly as Plepon 6 Tablet ER can affect blood sugar levels.
  • Do not stop taking Plepon 6 Tablet ER without talking to your doctor first as it may cause a worsening of symptoms.
     

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Plepon 6 Tablet ER may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Plepon 6 Tablet ER during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Plepon 6 Tablet ER may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Plepon 6 Tablet ER may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Plepon 6 Tablet ER should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Plepon 6 Tablet ER is not recommended in patients with end-stage kidney disease.
Liver

Liver

SAFE IF PRESCRIBED
Plepon 6 Tablet ER is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
Limited information is available on the use of Plepon 6 Tablet ER in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

Interaction with drugs

Taking Plepon with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Amiodarone (Oral Route)

Do not consume Amiodarone with Paliperidone.
Life-threatening

Escitalopram Oxalate (Oral Route)

Do not consume Escitalopram Oxalate with Paliperidone.
Life-threatening

Haloperidol (Oral Route)

Do not consume Haloperidol with Paliperidone.
Life-threatening

Ondansetron (Oral Route)

Do not consume Ondansetron with Paliperidone.
Life-threatening

Iloperidone (Oral Route)

Do not consume Iloperidone with Paliperidone.

Frequently asked questions

Paliperidone gets converted to risperidone in the body and thus exerts similar actions
No, Plepon 6 Tablet ER is not a narcotic
Yes, Plepon 6 Tablet ER is an atypical antipsychotic
Plepon 6 Tablet ER is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes
Yes, Plepon 6 Tablet ER is known to cause weight gain
Plepon 6 Tablet ER may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use
Oral Plepon 6 Tablet ER may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.

Fact Box

Chemical Class

Pyridopyrimidines

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Atypical Antipsychotics
Related ayurvedic ingredients
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100% genuine products
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Jagsam Pharma
Address: Shop No. 6 to 10, 1st Floor, Balaji Heights, Sector-11, Sanpada, Navi Mumbai-400 705

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Plepon 6 Tablet ER. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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