Medicine Overview of Piowa Tablet
Piowa 15 mg Tablet is used in the treatment of type 2 diabetes
. It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Side Effects of Piowa are Weight gain, Blurred vision, Respiratory tract infection, Numbness, Bone fracture.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Piowa 15 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Piowa 15 mg Tablet is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
In Depth Information on Piowa Tablet
Piowa 15 mg Tablet helps to control blood sugar level and avoids long-term complications.
You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Piowa 15 mg Tablet.
Full effect may be visible after several weeks of starting Piowa 15 mg Tablet.
Weight gain, headache, and swelling due to fluid build-up may occur.
- Notify your doctor if you experience shortness of breath, heart problems, or any abnormal swelling.
May not be suitable for patients with a history of heart failure or bladder cancer.
Piowa Tablet related warnings
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
WEIGH RISKS VS BENEFITS
Piowa 15 mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Piowa 15 mg Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Piowa 15 mg Tablet
Piowa 15 mg Tablet does not usually affect your ability to drive.
Piowa 15 mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Piowa 15 mg Tablet is recommended.
Use of Piowa 15 mg Tablet is not recommended in patients undergoing dialysis.
Piowa 15 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Piowa 15 mg Tablet may be needed. Please consult your doctor.
Use of Piowa 15 mg Tablet is not recommended in patients with severe liver disease.
If you miss a dose of Piowa 15 mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
Frequently asked questions about Piowa Tablet
Q. Is Piowa a blood thinner?
No. Piowa is an anti-diabetic medication. Blood thinners are the medicine that prevents the formation of a harmful blood clot. These include medicines like Aspirin, Heparin and Warfarin.
No. Piowa is not a diuretic. It is used in the treatment of Diabetes Mellitus. Diuretics are those medicine which increases urination.
Q. Can Piowa used in Hepatitis B infection?
Some studies have shown that Piowa may be helpful in preventing Hepatitis B Virus-associated Hepatocellular Cancer (Liver Cancer). However, these findings are still very preliminary and clear role has not been established.
Q. Can Piowa used in Hepatitis C infection?
Piowa has been shown to inhibit Liver Cancer (HCC) recurrence in overweight Hepatitis C Virus-infected diabetic patients. It also improved insulin resistance (a state where the body is resistant to the effects and functions of the insulin hormone) in them.
Q. Can Piowa used along with Vitamin D?
Studies indicate that Vitamin-D combined with Piowa may be more effective in improving Bone Mineral Density and Bone Metabolism than Vitamin-D or Piowa alone in the treatment of Diabetes Mellitus patients with kidney dysfunction (Diabetic Nephropathy).
Q. Can Piowa be used along with sitagliptin?
Combination therapy with Sitagliptin and Piowa leads to a substantial and sustained improvement in glycemic (blood sugar) control compared to the treatment with Piowa alone. This is useful for patients who cannot tolerate Metformin or Sulfonylureas.
Q. Is there any role of Piowa in Alzheimer disease?
Recent evidence suggests that Piowa may be beneficial in Alzheimer's disease (AD), decreasing the cognitive decline early in the disease process. However, larger studies are now in progress to establish the same.
Q. Can Piowa and repaglinide combined in diabetes treatment?
For patients who previously failed oral antidiabetic therapy, the combination of Repaglinide and Piowa have acceptable safety, with greater reductions of glycemic parameters (blood sugar levels) than using either agent alone.
Q. Does Piowa cause urinary bladder tumour?
Large population studies indicate that Piowa is associated with an increased risk of bladder cancer. The absence of an association of bladder cancer with the other drug of the same class, Rosiglitazone, suggests that the increased risk is drug specific and not a class effect.
Q. Can Piowa be used along with glimepiride in diabetes?
Piowa when added to Glimepiride in Patients with Diabetes Mellitus, has been found to significantly reduce plasma lipid levels and significant improvement in blood pressure control related to a reduction in the insulin resistance.
No. Piowa is not a steroid. It is an anti-diabetic medication which belongs to the class of thiazolidinediones.
Piowa is an anti-diabetes drug used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. Piowa acts as an insulin sensitizer and decreases the extent of insulin resistance in the body too.
Piowa cardiovascular safety profile compares favourably with that of Rosiglitazone. Piowa has been found to be associated with bladder tumours but causality assessment has not been proved yet.
Q. How does Piowa cause oedema?
Piowa increases the permeability of fluid in tiny blood vessels called capillaries. This results in easier movement of fluids across the membrane and their consequent accumulation, resulting in oedema (puffiness). Also, Piowa causes increased sodium and water reabsorption from the kidney that contributes to the oedema.
Q. How does Piowa cause bladder cancer?
The mechanism behind the link between Piowa use and bladder cancer is still unknown. Studies have suggested that use of Piowa for more than one year results in increased risk of development of tumour of the urinary bladder.
Q. How Piowa protects against atherosclerosis?
Studies in animals have concluded that Piowa improves the elasticity of the aortic wall ( the aorta is a large blood vessel that arises from the heart and supplies oxygenated blood to the rest of the body). This may be a mechanism by which it protects against atherosclerosis, but more studies are needed to confirm this.
Q. Can Piowa be used with insulin?
The addition of Piowa reduces daily insulin dosages, but study findings have not been consistent. Improvement of lipid profiles has also been weak with this combination therapy. Long-term studies are needed before any conclusions can be reached. Combination therapy should be primarily used for patients who achieve an insufficient reduction in blood sugar with insulin alone.
Q. Can Piowa used for dementia?
Findings indicate that Piowa treatment is associated with a reduced dementia risk in Diabetes mellitus patients. Prospective studies are needed to evaluate a possible neuroprotective effect in these patients in an ageing population.
Q. Can Piowa used for infertility?
Piowa may be of use in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as by drugs like Clomiphene, Dexamethasone, or Metformin.
Q. Can Piowa used for psoriasis?
The use of Piowa for plaque psoriasis treatment is controversial. Some studies revealed no effect of Piowa 30 mg daily neither on the clinical response of moderate-to-severe psoriasis whereas others demonstrate that it could be considered as an efficacious and safe agent for the treatment of plaque psoriasis.
Q. Can Piowa used for autism?
In a research study in a small number of autistic children, daily treatment with 30 or 60 mg Piowa for 3–4 months induced apparent clinical improvement. Piowa should be considered for further testing of therapeutic potential in autistic patients but as of now, autism is not an approved indication for Piowa use.
Q. Can Piowa be used in depression?
Piowa, either alone or as add-on therapy to conventional treatments, could clinically benefit patients of major depression according to a study.
Q. Can Piowa used for weight loss?
A recent study shows that although Piowa causes a significant decrease in blood sugar, HbA1C and lipid levels, it is associated with weight gain, which would limit its utility. It has not been shown to cause weight loss.
Q. Can Piowa be used to treat fatty liver?
Piowa has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.
Q. Can Piowa be used for secondary stroke prevention?
Piowa reduces recurrent stroke and major vascular events in stroke patients with insulin resistance, prediabetes, and diabetes mellitus. However, its use as a preventive therapy requires more research.
Severely interacts with other drugs like
Taking Piowa with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
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Medicines with composition Spironolactone: Aldactone
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Medicines with composition Pindolol: Visken
Medicines with composition Collagen Peptide: Nudiglue-C
Medicines with composition Orlistat: Orli-Misia, Redufat, Orlistat, Orlibee, Orlimac, O-Stat, Orlimax, Orlica, Orlean, Reeshape, Cobese, Orlitroy, Troyslim, Orlip X, Orlisis, Ishape, Nofat
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Medicines with composition Insulin Lispro: Humalog
Medicines with composition Clonidine: Arkamin
Medicines with composition Nicotinic acid / Niacin: Nicoglow
Medicines with composition Lactase: Cry NO
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