Peramnel 4 Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 12 Feb 2026 | 09:56 PM (IST)

Peramnel 4 Tablet belongs to a class of medicines known as antiepileptics. It is used to treat epilepsy (seizures) in people who have repeated seizures (fits). It helps reduce the frequency of seizures that affect a part or whole of the brain.

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Ampanel 4 Tablet

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Peramnel 4 Tablet

strip of 10 tablets

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Same composition

Ampanel 4 Tablet

strip of 10 tablets

Perampanel (4mg)

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General Information

Contains

Perampanel (4mg)

Marketer

Icon Life Sciences

Storage

Store below 30°C

The content is shown in English

Product introduction

Peramnel 4 Tablet is taken by mouth with or without food. However, it is advised to take it at the same time each day, preferably before going to bed. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may increase seizure frequency.

Some common side effects of this medicine include fatigue, anger, nausea, and balance disorder (loss of balance). It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should have a balanced diet and exercise regularly. It is important to inform your doctor if you develop any unusual changes in mood or depression as it may lead to suicidal thoughts.

Before taking it, you should tell your doctor if you have kidney problems, depression, or suicidal thoughts and if you are pregnant or planning to become pregnant. You should not breastfeed while taking this medicine. Alcohol may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness. Avoid alcohol while taking this medicine. Your kidney function may need to be tested often while taking this medicine.

Uses of Peramnel Tablet

Epilepsy/Seizures

Benefits of Peramnel Tablet

Epilepsy/Seizures
Peramnel 4 Tablet slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of Peramnel Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Peramnel

Sleepiness
Dizziness
Fatigue
Fall
Nausea
Weight gain
Vertigo
Impaired coordination
Altered walking
Balance disorder (loss of balance)
Abnormality of voluntary movements
Headache
Vomiting
Bruise
Abdominal pain
Anxiety

How to use Peramnel Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Peramnel 4 Tablet may be taken with or without food.

How Peramnel Tablet works

Peramnel 4 Tablet is an antiepileptic medication. It prevents seizures in patients with epilepsy by blocking a receptor in the brain known as the glutamate receptor, thereby suppressing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for Peramnel 4 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Take a healthy diet along with regular exercise.
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/ laptop.
- Take your medication on time.
Do not drive or do anything that requires mental focus until you know how Peramnel 4 Tablet affects you.
It may cause weight gain. Hence, monitor your weight regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Peramnel 4 Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Peramnel 4 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Peramnel 4 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Peramnel 4 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Peramnel 4 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Peramnel 4 Tablet should not be used in patients with severe liver disease.

Liver

CAUTION

Peramnel 4 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Peramnel 4 Tablet should not be used in severe liver disease

Interaction with drugs

Taking Peramnel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Progesterone (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection. Perampanel may reduce the efficacy of Progesterone.

Severe

Progesterone (Natural Micronized) (Oral Route)

Severe

Dienogest (Oral Route)

Severe

Progesterone (Natural Micronized) (Injection Route)

Severe

Dehydroepiandrosterone (Micronized) (Oral Route)

Frequently asked questions

Does Peramnel 4 Tablet have abuse potential?

Yes, Peramnel 4 Tablet has abuse potential in addition to its rewarding psychological or physiological effects. If a patient has a history of drug abuse then monitoring for Peramnel 4 Tablet abuse should be done.

What are the most serious side effects of Peramnel 4 Tablet?

Peramnel 4 Tablet may cause some serious psychiatric and behavioral side effects such as aggression, hostility, irritability, anger, and suicidal and murderous thoughts.

What are the withdrawal symptoms of Peramnel 4 Tablet?

Peramnel 4 Tablet may cause physical dependence which means that suddenly stopping it may cause withdrawal symptoms which include anxiety, nervousness, irritability, fatigue, weakness, lethargy, mood swings, and sleeplessness.

Does Peramnel 4 Tablet cause weight gain?

Yes, Peramnel 4 Tablet may cause weight gain as a side effect of this medicine. Consult your doctor if it bothers you.

What should I avoid while taking Peramnel 4 Tablet?

Peramnel 4 Tablet may cause sleepiness and dizziness, so alcohol consumption should be avoided as it may make you more sleepy and dizzy. You should avoid driving and using heavy machinery until and unless you know how Peramnel 4 Tablet affects you. You should also avoid getting pregnant and breastfeeding your baby.

Can I stop taking Peramnel 4 Tablet on my own?

No, you should not stop taking Peramnel 4 Tablet without consulting your doctor. Sudden discontinuity of Peramnel 4 Tablet or significant dose reduction may cause occurrence of unpleasant effects.

Fact Box

Chemical Class

Bipyridines and oligopyridines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

AMPA glutamate receptor antagonist

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1090-91.
Perampanel. Woodcliff Lake, New Jersey: Eisai Inc.; 2012 [revised Apr. 2016]. [Accessed 22 Mar 2019] (online) Available from:
Perampanel. Hatfield, UK: Eisai Manufacturing Limited; 2018. [Accessed 17 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
Perampanel. Parsippany, NJ: Teva Pharmaceuticals; [Accessed 12 Feb. 2026] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Icon Life Sciences
Address: Icon Life Sciences, Div. Of Mesmer Pharmaceuticals, No.202/6, Lane In.30, Phase-II, IDA, Cherlapally, Hyderabad, 500 051 AP

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Peramnel 4 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Peramnel Tablet

Benefits of Peramnel Tablet

Side effects of Peramnel Tablet

How to use Peramnel Tablet

How Peramnel Tablet works

All substitutes for Peramnel 4 Tablet

Perampa 4mg Tablet

Ampanel 4 Tablet

Torpanel 4 Tablet

Perampil 4mg Tablet

Hetram 4mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Progesterone (Oral Route)

Progesterone (Natural Micronized) (Oral Route)

Dienogest (Oral Route)

Progesterone (Natural Micronized) (Injection Route)

Dehydroepiandrosterone (Micronized) (Oral Route)

Frequently asked questions

Does Peramnel 4 Tablet have abuse potential?

What are the most serious side effects of Peramnel 4 Tablet?

What are the withdrawal symptoms of Peramnel 4 Tablet?

Does Peramnel 4 Tablet cause weight gain?

What should I avoid while taking Peramnel 4 Tablet?

Can I stop taking Peramnel 4 Tablet on my own?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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