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Perampil 4mg Tablet

Perampanel (4mg)

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Perampil 4mg Tablet belongs to a class of medicines known as antiepileptics. It is used to treat epilepsy (seizures) in people who have repeated seizures (fits). It helps reduce the frequency of seizures that affect a part or whole of the brain.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 06 Apr 2026 | 04:05 PM (IST)

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General Information

Contains

Perampanel (4mg)

Marketer

Alkem Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Perampil 4mg Tablet is taken by mouth with or without food. However, it is advised to take it at the same time each day, preferably before going to bed. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming. If you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may increase seizure frequency.

Some common side effects of this medicine include fatigue, anger, nausea, and balance disorder (loss of balance). It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should have a balanced diet and exercise regularly. It is important to inform your doctor if you develop any unusual changes in mood or depression as it may lead to suicidal thoughts.

Before taking it, you should tell your doctor if you have kidney problems, depression, or suicidal thoughts and if you are pregnant or planning to become pregnant. You should not breastfeed while taking this medicine. Alcohol may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness. Avoid alcohol while taking this medicine. Your kidney function may need to be tested often while taking this medicine.

Uses of Perampil Tablet

Epilepsy/Seizures

Benefits of Perampil Tablet

Epilepsy/Seizures
Perampil 4mg Tablet slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of Perampil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Perampil

Sleepiness
Dizziness
Fatigue
Fall
Nausea
Weight gain
Vertigo
Impaired coordination
Altered walking
Balance disorder (loss of balance)
Abnormality of voluntary movements
Headache
Vomiting
Bruise
Abdominal pain
Anxiety

How to use Perampil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perampil 4mg Tablet may be taken with or without food.

How Perampil Tablet works

Perampil 4mg Tablet is an antiepileptic medication. It prevents seizures in patients with epilepsy by blocking a receptor in the brain known as the glutamate receptor, thereby suppressing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for Perampil 4mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Take a healthy diet along with regular exercise.
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/ laptop.
- Take your medication on time.
Do not drive or do anything that requires mental focus until you know how Perampil 4mg Tablet affects you.
It may cause weight gain. Hence, monitor your weight regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Perampil 4mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Perampil 4mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Perampil 4mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Perampil 4mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Perampil 4mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Perampil 4mg Tablet should not be used in patients with severe liver disease.

Liver

CAUTION

Perampil 4mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Perampil 4mg Tablet should not be used in severe liver disease

Interaction with drugs

Taking Perampil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Progesterone (Oral Route)

It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraception. Your doctor may monitor your treatment closely and adjust the doses as per the observations. Use barrier methods (like condoms) for contraception to reduce the risk of HIV infection. Perampanel may reduce the efficacy of Progesterone.

Severe

Progesterone (Natural Micronized) (Oral Route)

Severe

Dienogest (Oral Route)

Severe

Progesterone (Natural Micronized) (Injection Route)

Severe

Dehydroepiandrosterone (Micronized) (Oral Route)

Frequently asked questions

Does Perampil 4mg Tablet have abuse potential?

Yes, Perampil 4mg Tablet has abuse potential in addition to its rewarding psychological or physiological effects. If a patient has a history of drug abuse then monitoring for Perampil 4mg Tablet abuse should be done.

What are the most serious side effects of Perampil 4mg Tablet?

Perampil 4mg Tablet may cause some serious psychiatric and behavioral side effects such as aggression, hostility, irritability, anger, and suicidal and murderous thoughts.

What are the withdrawal symptoms of Perampil 4mg Tablet?

Perampil 4mg Tablet may cause physical dependence which means that suddenly stopping it may cause withdrawal symptoms which include anxiety, nervousness, irritability, fatigue, weakness, lethargy, mood swings, and sleeplessness.

Does Perampil 4mg Tablet cause weight gain?

Yes, Perampil 4mg Tablet may cause weight gain as a side effect of this medicine. Consult your doctor if it bothers you.

What should I avoid while taking Perampil 4mg Tablet?

Perampil 4mg Tablet may cause sleepiness and dizziness, so alcohol consumption should be avoided as it may make you more sleepy and dizzy. You should avoid driving and using heavy machinery until and unless you know how Perampil 4mg Tablet affects you. You should also avoid getting pregnant and breastfeeding your baby.

Can I stop taking Perampil 4mg Tablet on my own?

No, you should not stop taking Perampil 4mg Tablet without consulting your doctor. Sudden discontinuity of Perampil 4mg Tablet or significant dose reduction may cause occurrence of unpleasant effects.

Fact Box

Chemical Class

Bipyridines and oligopyridines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

AMPA glutamate receptor antagonist

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1090-91.
Perampanel. Woodcliff Lake, New Jersey: Eisai Inc.; 2012 [revised Apr. 2016]. [Accessed 22 Mar 2019] (online) Available from:
Perampanel. Hatfield, UK: Eisai Manufacturing Limited; 2018. [Accessed 17 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
Perampanel. Parsippany, NJ: Teva Pharmaceuticals; [Accessed 12 Feb. 2026] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Perampil 4mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Perampil 4mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Perampil Tablet

Benefits of Perampil Tablet

Side effects of Perampil Tablet

How to use Perampil Tablet

How Perampil Tablet works

All substitutes for Perampil 4mg Tablet

Perampa 4mg Tablet

Ampanel 4 Tablet

Torpanel 4 Tablet

Hetram 4mg Tablet

Addperam 4mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Progesterone (Oral Route)

Progesterone (Natural Micronized) (Oral Route)

Dienogest (Oral Route)

Progesterone (Natural Micronized) (Injection Route)

Dehydroepiandrosterone (Micronized) (Oral Route)

Frequently asked questions

Does Perampil 4mg Tablet have abuse potential?

What are the most serious side effects of Perampil 4mg Tablet?

What are the withdrawal symptoms of Perampil 4mg Tablet?

Does Perampil 4mg Tablet cause weight gain?

What should I avoid while taking Perampil 4mg Tablet?

Can I stop taking Perampil 4mg Tablet on my own?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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