Pentasa 500mg Tablet PR is an anti-inflammatory medicine used to treat a type of bowel disease known as ulcerative colitis. It helps to reduce symptoms such as diarrhea, bleeding and stomach pain by reducing inflammation in the bowel.
Pentasa 500mg Tablet PR may also be used to treat another type of bowel disease known as Crohn’s ileocolitis. It should be taken with food. The dose will depend on what you are being treated for but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.
The most common side effects of this medicine include nausea, diarrhea, stomach pain, headache, itching, flatulence, and vomiting. If these symptoms bother you, do not go away, or get worse, let your doctor know. There may be ways of reducing or preventing them. Some people may get a severe allergic reaction that needs urgent medical attention. Contact your doctor immediately if you notice symptoms like swelling of the face, tongue, throat, or lips, unusual bleeding, bruising, rash, fever, sore throat, or excessive tiredness.
Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.
Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation and ulcers in the lining of the colon and rectum, leading to symptoms like diarrhea, rectal bleeding, and abdominal pain. Pentasa 500mg Tablet PR helps reduce inflammation, promote healing of the intestinal lining, and maintain long-term remission, leading to improved bowel control and quality of life.
In Crohn’s disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, causing symptoms like abdominal pain, diarrhea, and fatigue. Pentasa 500mg Tablet PR is used in mild to moderate cases to reduce inflammation and manage flare-ups. It can help prevent disease progression, reduce the need for steroids, and support intestinal health over time.
Side effects of Pentasa Tablet PR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pentasa
Stomach pain/epigastric pain
Flatulence
Headache
Vomiting
Diarrhea
Nausea
Abdominal pain
Rash
How to use Pentasa Tablet PR
Use it as advised by your doctor or check the label for directions before use. Pentasa 500mg Tablet PR may be taken with or without food, but it is better to take it at a fixed time.
How Pentasa Tablet PR works
Pentasa 500mg Tablet PR is an aminosalicylate. It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation (swelling) in the intestines. This reduces ulceration, bleeding and stomach pain, and prevents future flare-ups of the disease.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Pentasa 500mg Tablet PR. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Pentasa 500mg Tablet PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Pentasa 500mg Tablet PR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. If you are taking Pentasa 500mg Tablet PR, monitor the baby for diarrhea.
Driving
SAFE
Pentasa 500mg Tablet PR does not usually affect your ability to drive.
Kidney
CAUTION
Pentasa 500mg Tablet PR should be used with caution in patients with kidney disease. Dose adjustment of Pentasa 500mg Tablet PR may be needed. Please consult your doctor. Use of Pentasa 500mg Tablet PR is not recommended in patients with severe kidney disease.
Liver
CAUTION
Pentasa 500mg Tablet PR should be used with caution in patients with liver disease. Dose adjustment of Pentasa 500mg Tablet PR may be needed. Please consult your doctor.
What if you forget to take Pentasa Tablet PR?
If you miss a dose of Pentasa 500mg Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
You have been prescribed Pentasa 500mg Tablet PR for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
Do not take Pentasa 500mg Tablet PR if you are allergic to aspirin or if you have blood disorders.
Do not stop taking the medication suddenly without talking to your doctor.
You have been prescribed Pentasa 500mg Tablet PR for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
Take it with food. Do not break, chew, or crush the tablets or granules. Swallow them whole with plenty of water.
Do not take antacids with Pentasa 500mg Tablet PR as it can make your inflammation worse.
Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
Do not take Pentasa 500mg Tablet PR if you are allergic to aspirin or if you have blood disorders.
Fact Box
Chemical Class
Aminosalicylic Acids Derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
5-Aminosalicylic Acid (5-ASA)
Interaction with drugs
Taking Pentasa with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Your doctor may monitor your blood cell count and adjust the doses as per the observations.
Concurrent use may increase the risk of low blood cell counts.
If concurrent use can not be avoided, your doctor may monitor your blood cell counts.
Concurrent use may increase the risk for blood disorders, bone marrow failure, and associated... More
If concurrent use cannot be avoided, your doctor may monitor your blood cell counts.
Concurrent use may increase the risk for blood disorders, bone marrow failure, and associated ... More
If concurrent use can not be avoided, your doctor may monitor your blood cell counts.
Concurrent use may increase the risk of fall in white blood cell count.
Talk to your doctor if you notice any unusual symptoms.Doctor may monitor your liver function. Lactitol may raise blood levels of the active form of Mesalazine.
Suffering from ultratics colitis i have done colonoscopy test 04 months back From 05 months how many months I have to take medicines is it cure completely
Dr. Kunal Parasar
Surgical Gastroenterology
Ulcerative colitis is a lifelong disease with remission and exacerbations. Durations of remission cant b predicted all d time
Hi, I was diagnosed for Ulcerative Colitis in 2009. I was administered with Mesacol , I was back to normal. In past 1 month , after having food lunch or dinner I feel uneasy such as indigestion, having to force for motions next day. Sometimes Iam unable to pass motions. I feel tired also. Pls suggest.
Dr. Kunal Parasar
Surgical Gastroenterology
Ulcerative colitis is a lifong disease q with remission and exacerbation . U should b under constant follow up of ur gastroenterologist
https://goo.gl/forms/5QhDt8ZurRhhcjvD2 Kindly fill the health information so that I can advice best products to you thankshttps://www.1mg.com/otc/jiva-digestol-tablet-otc329948One ?one tablet morning & evening after taking food , use at least 1-2 monthsTake buttermilk in lunch timeAvoid taking milk & milk Product
What were the side-effects while using Pentasa 500mg Tablet PR?
No Side Effec*
64%
Hair loss
11%
Abdominal pai*
7%
Vomiting
4%
Diarrhea
4%
*No Side Effect, Abdominal pain
How do you take Pentasa Tablet PR?
With food
67%
With or witho*
30%
Empty stomach
4%
*With or without food
Please rate Pentasa 500mg Tablet PR on price
Expensive
65%
Average
27%
Not Expensive
7%
FAQs
My symptoms have improved can I stop taking Pentasa 500mg Tablet PR?
Continue to take Pentasa 500mg Tablet PR as advised by the doctor, even if you feel better at the beginning of your treatment. Do not stop taking Pentasa 500mg Tablet PR without consulting your doctor.
Can I drink alcohol while taking Pentasa 500mg Tablet PR?
You should avoid alcohol if you have ulcerative colitis, as alcohol will irritate your stomach and intestine which will worsen your condition. Although alcohol does not interfere with the working of Pentasa 500mg Tablet PR, you should consult your doctor before taking alcohol.
Does Pentasa 500mg Tablet PR cause joint pain?
Yes, Pentasa 500mg Tablet PR may cause joint pain. If the pain continues and bothers you inform your doctor.
When is the best time to take Pentasa 500mg Tablet PR?
Take Pentasa 500mg Tablet PR exactly as directed by your doctor.
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
Mesalazine/Mesalamine. Milan, Italy: Cosmo S.p.A.; 1987 [revised date]. [Accessed on 28 Mar. 2018] (online) Available from:
Mesalamine. Weiterstadt Germany: Warner Chilcott Deutschland GmbH; [revised May 2010]. [Accessed 28 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Mesalamine. [Updated 2019 Apr 1]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
National Health Service. Mesalazine. [Last Reviewed: 19 Jul. 2021]. [Accessed 11 Jul. 2023]. (online) Available from:
Mesalazine [Package Insert]. Saint-Prex, Switzerland: Ferring International Center SA. [Accessed 11 Jul. 2023]. (online) Available from:
Country of origin: Switzerland Expires on or after: July, 2026
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