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Pentasa 1gm Suppository

Mesalazine (1gm)

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Pentasa 1gm Suppository is a medicine used to treat Crohn’s disease and ulcerative colitis. It is used when the lining tissue of the inner rectum becomes inflamed (proctitis). It helps to reduce symptoms such as diarrhea, bleeding, and stomach pain by reducing inflammation in the bowel.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 29 Sep 2025 | 12:23 PM (IST)

₹748

₹811.3

8% off

7 suppositories

Get by 2pm, Tomorrow

Gurgaon

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Pentasa 1gm Suppository is only for the rectal route and should not be taken orally. It must be used under the supervision of a doctor or healthcare professional. Stay in a lying position for at least 15 minutes after the insertion of suppositories. The dose will depend on what you are being treated for, but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen.

The most common side effects of this medicine include rectal discomfort, rash, itching, and fever. If these symptoms bother you or do not go away or get worse, tell your doctor. There may be ways of reducing or preventing them.

Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking, as some may affect or be affected by this medicine. You may be asked for kidney and liver function tests before and after the treatment.

Uses of Pentasa Suppository

Benefits of Pentasa Suppository

Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the colon and rectum. Pentasa 1gm Suppository helps reduce the inflammation in the intestinal lining by targeting the disease locally. Reduction in inflammation promotes mucosal healing and causes symptoms like abdominal pain, diarrhea, and rectal bleeding to subside.

Crohn’s disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, causing symptoms like abdominal pain, diarrhea, and fatigue. Pentasa 1gm Suppository is used in mild to moderate cases to reduce inflammation and manage flare-ups. It can help prevent disease progression, reduce the need for steroids, and support intestinal health over time.

Side effects of Pentasa Suppository

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pentasa

Flatulence
Headache
Diarrhea
Nausea
Rectal discomfort
Abdominal pain
Vomiting
Rash

How to use Pentasa Suppository

Remove the wrapper from the suppository before inserting it. Keep lying down for about 15 minutes after insertion so that the suppository does not come out before it melts.

How Pentasa Suppository works

Pentasa 1gm Suppository is an aminosalicylate. It works directly on the site of inflammation (swelling) in the lower parts of the large intestine (colon and rectum) to provide rapid relief from attacks of ulcerative colitis. It suppresses the production of chemical messengers (prostaglandins) that cause intestinal inflammation, thereby reducing ulceration, bleeding, and painful symptoms.

All substitutes for Pentasa 1gm Suppository

For information purposes only. Consult a doctor before taking any medicine.

Mesacol 1g Suppository

by Sun Pharmaceutical Industries Ltd

₹59.57/suppository

44% cheaper

Vegaz Suppository

by Dr Reddy's Laboratories Ltd

₹41.86/suppository

61% cheaper

Quick tips

Pentasa 1gm Suppository is for administration into the back passage (rectum). It must not be taken by mouth.
Avoid taking antacids with Pentasa 1gm Suppository as it can make your inflammation worse.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

Pentasa 1gm Suppository may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Pentasa 1gm Suppository is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If you are taking Pentasa 1gm Suppository, monitor the baby for diarrhea.

Driving

No interaction found/established

Kidney

CAUTION

Pentasa 1gm Suppository should be used with caution in patients with kidney disease. Dose adjustment of Pentasa 1gm Suppository may be needed. Please consult your doctor.
Use of Pentasa 1gm Suppository is not recommended in patients with severe kidney disease.

Liver

CAUTION

Pentasa 1gm Suppository should be used with caution in patients with liver disease. Dose adjustment of Pentasa 1gm Suppository may be needed. Please consult your doctor.

Interaction with drugs

Taking Pentasa with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Azathioprine (Oral Route)

If concurrent use is essential, your doctor may monitor blood cell counts and your overall treatment closely.

Moderate

Mercaptopurine (Oral Route)

If concurrent use is essential, your doctor may monitor blood cell counts and your overall treatment closely.

Moderate

Deferiprone (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.

Mild

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Frequently asked questions

My symptoms have improved can I stop using Pentasa 1gm Suppository?

Continue to use Pentasa 1gm Suppository as advised by the doctor, even if you feel better at the beginning of your treatment. Do not stop using Pentasa 1gm Suppository without consulting your doctor.

I am suffering from ulcerative colitis (UC) and piles can I use Pentasa 1gm Suppository?

Pentasa 1gm Suppository is used for the treatment of ulcerative colitis; however, you should not start using the medicine on your own. Consult a doctor who will prescribe you the right dose and duration of treatment and will address any related or other concerns that you have.

Can I drink alcohol while using Pentasa 1gm Suppository?

You should avoid alcohol if you have ulcerative colitis, as alcohol will irritate your stomach and intestines, which will worsen your condition. Although alcohol does not interfere with the working of Pentasa 1gm Suppository, you should consult your doctor before using alcohol.

What is the best time to use Pentasa 1gm Suppository?

Use Pentasa 1gm Suppository exactly as directed by your doctor. If you are using Pentasa 1gm Suppository suppositories, you should insert them rectally, once daily at bedtime.

Fact Box

Chemical Class

Aminosalicylic Acids Derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

5-Aminosalicylic Acid (5-ASA)

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 867-69.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Mesalamine. [Updated 2019 Apr 1]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Mesalazine [Product Information]. Pymble, NSW: Ferring Pharmaceuticals Pty Ltd.; 2023. [Accessed 11 Jul. 2023]. (online) Available from:
Mesalazine [New Zealand Data Sheet]. Mt Wellington, Auckland: Pharmaco (NZ) Ltd.; 2023. [Accessed 11 Jul. 2023]. (online) Available from:

User feedback

Patients taking Pentasa 1gm Suppository

Once A Day

86%

Twice A Day

10%

Alternate Day

Twice A Week

What are you using Pentasa Suppository for?

Ulcerative colitis

93%

Crohn’s disease

How much was the improvement?

Average

42%

Poor

31%

Excellent

27%

What were the side-effects while using Pentasa 1gm Suppository?

No Side Effect

57%

Abdominal pain

14%

Vomiting

Flatulence

Diarrhea

How do you take Pentasa Suppository?

With or without food

50%

With food

42%

Empty stomach

Please rate Pentasa 1gm Suppository on price

Expensive

67%

Average

19%

Not Expensive

14%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ferring Pharmaceuticals
Address: K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA

Vendor Details

Country of origin: Switzerland
A licensed vendor partner from your nearest location will deliver Pentasa 1gm Suppository. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Pentasa 1gm Suppository

Save more with additional offers

General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Pentasa Suppository

Benefits of Pentasa Suppository

Side effects of Pentasa Suppository

How to use Pentasa Suppository

How Pentasa Suppository works

All substitutes for Pentasa 1gm Suppository

Mesacol 1g Suppository

Vegaz Suppository

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Azathioprine (Oral Route)

Mercaptopurine (Oral Route)

Deferiprone (Oral Route)

Clozapine (Oral Route)

Frequently asked questions

My symptoms have improved can I stop using Pentasa 1gm Suppository?

I am suffering from ulcerative colitis (UC) and piles can I use Pentasa 1gm Suppository?

Can I drink alcohol while using Pentasa 1gm Suppository?

What is the best time to use Pentasa 1gm Suppository?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

User feedback

Patients taking Pentasa 1gm Suppository

What are you using Pentasa Suppository for?

How much was the improvement?

What were the side-effects while using Pentasa 1gm Suppository?

How do you take Pentasa Suppository?

Please rate Pentasa 1gm Suppository on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests