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Pazobrite 400 Tablet

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Product introduction

Pazobrite 400 Tablet is a protein kinase inhibitor used in the treatment of kidney cancer and soft tissue sarcoma.

Pazobrite 400 Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Diarrhea and high blood pressure are the most common side effects of this medicine. Doctor may advise for regular monitoring of your blood pressure while on treatment. Drink plenty of fluids to overcome diarrhea or consult with your doctor if it bothers you. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Hence, inform your doctor if you experience fever, flu-like symptoms and shortness of breath.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Pazobrite Tablet

Benefits of Pazobrite Tablet

In Kidney cancer

Pazobrite 400 Tablet is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Soft tissue sarcoma

Soft tissue sarcoma is a type of sarcoma that develops in tissues such as bone and muscles. Pazobrite 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Follow your doctor’s instructions carefully and let your doctor know if any of the side effects bother you.

Side effects of Pazobrite Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pazobrite

  • Headache
  • Nausea
  • Vomiting
  • Musculoskeletal (bone, muscle or joint) pain
  • Fatigue
  • Change in color of hair
  • Diarrhea
  • High blood pressure
  • Decreased appetite
  • Weight loss
  • Taste change
  • Abnormal skin pigmentation
  • Hair discoloration
  • Tumor pain
  • Breathlessness

How to use Pazobrite Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pazobrite 400 Tablet is to be taken empty stomach.

How Pazobrite Tablet works

Pazobrite 400 Tablet is an anti-cancer medication. It works by binding and inhibiting the enzyme receptors (tyrosine kinase) that are responsible for the proliferation of the cancerous cells. It also restricts the growth of new blood vessels within the tumor. This is how it works against cancer.

Safety advice

It is not known whether it is safe to consume alcohol with Pazobrite 400 Tablet. Please consult your doctor.
Pazobrite 400 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
Pazobrite 400 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Pazobrite 400 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Pazobrite 400 Tablet is safe to use in patients with kidney disease. No dose adjustment of Pazobrite 400 Tablet is recommended.
Pazobrite 400 Tablet should be used with caution in patients with liver disease. Dose adjustment of Pazobrite 400 Tablet may be needed. Please consult your doctor.
Use of Pazobrite 400 Tablet is not advised in patients with moderate to severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Pazobrite 400 Tablet
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Votrient 400mg Tablet
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Pazliz 400 Tablet
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Fact Box

Chemical Class
Alkyldiarylamines Derivative
Habit Forming
Therapeutic Class
Action Class
Tyrosine kinase inhibitors

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Q. Is Pazobrite 400 Tablet a chemotherapy medicine?

Pazobrite 400 Tablet is not a conventional chemotherapy medicine. It belongs to a class of medicine called a protein kinase inhibitor. Pazobrite 400 Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.

Q. How should I take Pazobrite 400 Tablet?

Pazobrite 400 Tablet should be taken orally by mouth once a day or as directed by your doctor. Swallow the tablets whole with water, do not break or crush the tablets. This affects the way the medicine is absorbed and may increase the chance of side effects.

Q. Can Pazobrite 400 Tablet be taken with food?

Pazobrite 400 Tablet should be taken on an empty stomach, at least 1 hour before or 2 hours after food. If it is taken with food, the dosage may need to be increased. Doing this will in turn cause more side effects.

Q. How will I know if Pazobrite 400 Tablet is helping me?

The duration for which you have to continue taking Pazobrite 400 Tablet varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.

Q. Are there any food restrictions while I’m taking Pazobrite 400 Tablet?

Yes, it is best to avoid grapefruit and grapefruit juice while on Pazobrite 400 Tablet, as it may affect how the medicine works in your body. Ask your doctor about any additional foods you should avoid.

Q. How long I have to take Pazobrite 400 Tablet?

The duration for which you have to continue taking Pazobrite 400 Tablet varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.

Q. What is the most important information I need to know about Pazobrite 400 Tablet?

Pazobrite 400 Tablet may cause severe or life-threatening liver damage. Inform your doctor if you have or had liver disease. If you experience any of the following symptoms such as discoloration of the skin or eyes (yellowing), dark urine, extreme tiredness, nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, or unusual bleeding or bruising, call your doctor immediately. Your doctor may ask you to take some lab tests before you start taking Votrient. After you start taking Votrient, you may need to take those lab tests at weeks 3, 5, 7 and 9 and then at months 3 and 4. Your doctor may also prescribe additional tests if necessary. Periodic testing should then continue after 4 months.
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  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1072-73.
  2. Pazopanib. Research Triangle Park, North Carolina: GlaxoSmithKline; 2009 [revised Apr. 2012]. [Accessed 24 Jan. 2019] (online) Available from:External Link
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:External Link

Marketer details

Name: Torrent Pharmaceuticals Ltd
Address: Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.

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