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Norip 75mg Tablet SR

Nortriptyline (75mg)
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Norip 75mg Tablet SR is an antidepressant that is used to treat depression. It works by increasing the levels of certain chemical messengers in the brain that help improve mood, relieve symptoms of depression, and restore emotional balance.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 15 Jul 2026 | 01:05 AM (IST)
₹80.5 MRP ₹91.2212% off 
 
 
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Norip 75mg Tablet SR image
Norip 75mg Tablet SR image

Product introduction

Take Norip 75mg Tablet SR exactly as prescribed by your doctor. It can be taken with or without food, preferably at the same time each day. Since it may cause drowsiness, your doctor may advise you to take it at bedtime. Continue taking it regularly even if you start feeling better, as it may take a few weeks before you notice the full benefit. Do not stop taking this medicine suddenly without consulting your doctor, as doing so may cause withdrawal symptoms and increase the risk of your symptoms returning.


The most common side effects of Norip 75mg Tablet SR include dry mouth, constipation, blurred vision, dizziness, headache, increased heart rate, drowsiness, and difficulty passing urine. It may also cause a sudden drop in blood pressure when you stand up, making you feel dizzy or lightheaded. Drink plenty of fluids, maintain a fibre-rich diet to help prevent constipation, and consult your doctor if side effects persist or become bothersome.


Avoid drinking alcohol while taking Norip 75mg Tablet SR, as it can increase drowsiness and impair alertness. Do not drive or operate machinery until you know how this medicine affects you. Inform your doctor if you have heart disease, glaucoma, seizures, liver disease, or difficulty passing urine before starting treatment. Tell your doctor about all other medicines you are taking, especially antidepressants and medicines that affect heart rhythm, as they may interact with this medicine.


If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Seek immediate medical attention if you experience worsening depression, unusual changes in mood or behaviour, or thoughts of self-harm or suicide, particularly during the first few weeks of treatment or after a change in dose.

Uses of Norip Tablet SR

Benefits of Norip Tablet SR

Treatment of Depression
Depression is a condition marked by persistent sadness, loss of interest, and low energy that disrupts daily life. Norip 75mg Tablet SR helps lift mood, restore interest in activities, and improve overall emotional balance, supporting better mental health and well-being.

Side effects of Norip Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Norip
  • Tremors
  • Arrhythmia (irregular heartbeats)
  • Palpitations
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Dryness in mouth
  • Constipation
  • Nausea
  • Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Norip Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Norip 75mg Tablet SR may be taken with or without food.

How Norip Tablet SR works

Norip 75mg Tablet SR is a tricyclic antidepressant. It works by increasing the levels of certain chemical messengers in the brain that help regulate mood, thereby relieving the symptoms of depression.

Quick tips

  • Consider taking this medicine at night, as it may cause drowsiness or sleepiness.
  • Do not drive, operate machinery, or do anything that requires alertness until you know how this medicine affects you.
  • Avoid drinking alcohol while taking Norip 75mg Tablet SR, as it may increase drowsiness and dizziness.
  • Do not stop taking this medicine suddenly without consulting your doctor, as it may worsen your condition or cause withdrawal symptoms.
  • Inform your doctor immediately if you notice unusual changes in mood or behavior, worsening depression, or suicidal thoughts.
  • Your doctor may advise regular blood tests to monitor your blood cell count and sodium or blood sugar levels, if needed.
  • Tell your doctor about all other medicines you are taking, as Norip 75mg Tablet SR can interact with several medications.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Norip 75mg Tablet SR may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Norip 75mg Tablet SR is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Norip 75mg Tablet SR should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Norip 75mg Tablet SR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Norip 75mg Tablet SR may affect your alertness which may affect your ability to drive.
Kidney

Kidney

CAUTION
Norip 75mg Tablet SR should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Norip 75mg Tablet SR should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Norip 75mg Tablet SR is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Norip with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Nortriptyline. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Nortriptyline. Please consult your doctor.
Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Nortriptyline.
Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Nortriptyline. If Tranylcypromine is essential, ensure a gap of At least 2 weeks after discontinuing Nortriptyline. Please consult your doctor.
Severe

Tramadol (Injection Route)

Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitation, and consult your doctor if you experience them. Your doctor may alter or discontinue the medicines accordingly.
Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Frequently asked questions

Norip 75mg Tablet SR is used to treat depression and nocturnal (night time) bedwetting in children. It restores the chemical imbalance in the brain and enhances mood and behavior. In some cases, it may also be prescribed to relieve neuropathic (nerve) pain.
Yes, Norip 75mg Tablet SR can be taken for nerve pain. Your doctor may prescribe this medicine in combination with gabapentin. Nerve pain (or neuropathic pain) is commonly described as a shooting, burning or stabbing type of pain that may be associated with tingling, numbness or a pin and needles like feeling. The pain may be spontaneous which means it may be triggered without the presence of any stimulating factor. Additionally, you may experience an increase in the sensitivity to touch. Consult your doctor if you experience such pain.
The side effects of Norip 75mg Tablet SR are increased heart rate, weight gain, difficulty in urination, orthostatic hypotension (sudden decrease in blood pressure on standing), dryness in mouth and constipation. Please consult your doctor if these side effects do not go away or worry you.
Norip 75mg Tablet SR and amitriptyline belong to the same category of medicines with similar action, but their effect may vary upon individual response.
Norip 75mg Tablet SR is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
No, you must not stop taking Norip 75mg Tablet SR suddenly even if you are feeling better as it may worsen your condition. It may also cause withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever and irritability. Continue taking Norip 75mg Tablet SR for the duration prescribed by your doctor to get maximum benefit. If any of the side effects are bothering you, consult your doctor. In case you have completed your course of treatment, your doctor will reduce your dose gradually before taking you off this medicine completely.
Norip 75mg Tablet SR may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if your alertness is affected. It is not advisable to drink alcohol during treatment with this medicine as it might worsen the drowsiness. Tell your doctor if you have any problems with your liver or kidneys. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Yes, Norip 75mg Tablet SR can cause urinary problems. It is more commonly seen in elderly people who are above 65 years of age. The person may face difficulty in passing urine which can further lead to a urinary tract infection. You should consult your doctor immediately if you develop these symptoms.
An overdose of Norip 75mg Tablet SR can be significantly dangerous. In case of an overdose, you may experience symptoms such as blurred vision, fast or irregular heartbeats, dry mouth and tongue, fits and fever. You may also experience agitation (anxiety), confusion, hallucinations, uncontrolled movements, low blood pressure, difficulty breathing, discoloration of the skin (turning blue), drowsiness, loss of consciousness, or you may even go into a state of coma. Immediately consult your doctor and seek medical help if you have taken more than the recommended amount of Norip 75mg Tablet SR.
If you have missed a dose of Norip 75mg Tablet SR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Before taking Norip 75mg Tablet SR, you should tell your doctor if you are allergic to Norip 75mg Tablet SR or any of its ingredients to avoid any allergic reactions. Inform your doctor if you have any problems with your heart, liver, thyroid, prostate or kidneys. Tell your doctor if you have or ever had epilepsy (seizures or fits), diabetes, or glaucoma. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Also, inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Yes, Norip 75mg Tablet SR is effective if taken in the dose and duration prescribed by the doctor. Do not consume more than the recommended dose and avoid skipping doses. Inform your doctor if you experience any side effects while taking Norip 75mg Tablet SR to know about ways to manage or prevent them. It may take a few weeks for you to see improvement in your symptoms. However, the treatment may be continued for a few months for effective management of your condition.

Fact Box

Chemical Class

Dibenzocycloheptenes

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Tricyclic Antidepressants (TCAs)

References

  1. Stahl SM, editor. Nortriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 477-83.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1006-1007.
  3. Nortriptyline [Summary of Product Characteristics]. Ashbourne, Ireland: Pharmafile Limited; 2026. [Accessed 01 Ju. 2026] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Tripada Healthcare Pvt Ltd
Address: 3 Yogi Complex, Nr Doordarshan, Kendra, Thaltej, Ahmedabad, India 380054.

Vendor Details

Country of origin: India
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