Noctaderm Cream

Doxepin (5% w/w)

Genuine

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Prescription

required

Noctaderm Cream is used to treat eczema (a condition characterized by scaly, dry, and itchy skin), mainly atopic dermatitis.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Jan 2026 | 10:15 AM (IST)

MRP ₹36.83

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Gurgaon

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General Information

Contains

Doxepin (5% w/w)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Noctaderm Cream works by increasing the level of chemical messengers in the brain that stabilizes and enhances the mood. It must be used with a valid doctor's prescription. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed any dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor. Your dose will need to be gradually decreased when the doctor decides to stop it.

The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, and constipation. Initially, this medicine may also cause a sudden drop in the blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may even cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects are rare.

Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can get extra side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should strictly be avoided as alcohol interacts with this medicine to cause serious health issues.

Uses of Noctaderm Cream

Treatment of Eczema

Benefits of Noctaderm Cream

Treatment of Eczema
Eczema is a skin condition where patches of skin become inflamed, itchy, red, cracked, and rough. Noctaderm Cream is effective in treating inflammation and itching in eczema. It works by reducing the actions of chemicals in the body that cause inflammation of the skin. When used correctly it is a safe and effective treatment. Noctaderm Cream reduces the redness, rash, pain, or itchiness caused by your skin’s reaction to an irritant. This improves your self-esteem and confidence as your appearance changes. You should always use the cream or ointment as prescribed and only apply the amount you have been told to. Keep using it for as long as it is prescribed to get the full benefits.

Side effects of Noctaderm Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Noctaderm

Dizziness
Sleepiness
Application site reactions (burning, irritation, itching and redness)

How to use Noctaderm Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Noctaderm Cream works

Noctaderm Cream works in atopic dermatitis (eczema) by blocking the action of a substance called histamine. This helps to reduce itching.

All substitutes for Noctaderm Cream

For information purposes only. Consult a doctor before taking any medicine.

Galdopin Cream

by Galcare Pharmaceutical Pvt Ltd

₹6.7/gm of cream

172% costlier

Quick tips

It can be used for up to 8 days at a time.
Apply a very thin layer on the affected area and rub it gently.
Do not apply this cream to more than 10% of the body surface area as that may increase the chances of side effects.
It can cause drowsiness. Do not drive or do anything requiring concentration until you know how Noctaderm Cream affects you.
Avoid direct contact from the eyes, if it happens rinse eyes with plenty of water.

Safety advice

Alcohol

No interaction found/established

Pregnancy

SAFE IF PRESCRIBED

Noctaderm Cream is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Noctaderm Cream may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Interaction with drugs

Taking Noctaderm with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Hydroxyzine (Oral Route)

Do not consume Hydroxyzine with Doxepin.

Severe

Procarbazine (Oral Route)

Avoid concurrent use. Please consult with your doctor.

Mild

Domperidone (Oral Route)

Do not consume Domperidone with Doxepin.

Mild

Sertraline (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Sertraline may raise blood levels of Doxepin.

Frequently asked questions

What is Noctaderm Cream used for?

Noctaderm Cream is a medicine used to treat eczema. Eczema is a skin condition in which the skin becomes dry, itchy, scaly, inflamed, red, and rough. The medicine effectively alleviates the symptoms if used in the dose and duration as advised by the doctor.

What are the side effects of Noctaderm Cream?

Noctaderm Cream may cause side effects such as application site burning, irritation, itching, and redness. However, these usually resolve on their own after some time. But, if the symptoms do not subside or worry you, please consult your doctor.

How does it help to relieve itching?

Noctaderm Cream helps to relieve itching by blocking the release of a chemical called histamine. This chemical is responsible for causing itching in the affected area. Therefore, Noctaderm Cream effectively alleviates itching and provides symptomatic relief.

How to use Noctaderm Cream?

Before using Noctaderm Cream, wash the affected area with a mild soap and water, rinse and pat dry. Apply a thin layer of Noctaderm Cream to the affected skin. Gently and thoroughly massage it into the skin. Be careful, avoid getting this cream in the eyes or mouth. If Noctaderm Cream gets in your eyes accidentally, wash with plenty of water and call your doctor if your eyes are irritated.

What precautions do I need to take while using Noctaderm Cream?

You need to be careful while applying the cream. Ensure the cream does not get in the eyes or mouth. However, if Noctaderm Cream gets in your eyes, rinse off with plenty of water immediately and contact your doctor. You must not use Noctaderm Cream if you are allergic to it or any of its ingredients. Tell your doctor if you notice any allergic reaction while using it for the first time. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Do not cover the area being treated with Noctaderm Cream with a bandage, as this may increase the absorption of this medicine and increase the side effects. Do not use more than what is recommended to relieve your symptoms faster. Using more than what is advised will only increase the side effects. Let your doctor know if you are planning to conceive. Pregnant and breastfeeding mothers should use Noctaderm Cream only if prescribed by the doctor.

Fact Box

Chemical Class

Dibenzoxepines

Habit Forming

Therapeutic Class

DERMA

Action Class

Tricyclic Antidepressants (TCAs)

References

Stahl SM, editor. Doxepin. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 211-17.
Skidgel RA, Kaplan AP, Erdös EG. Histamine, Bradykinin, and Their Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 923.
Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1063.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 430-31.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:

User feedback

What are you using Noctaderm Cream for?

Atopic dermatitis

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How much was the improvement?

Excellent

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What were the side-effects while using Noctaderm Cream?

No Side Effect

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Acme Plaza, Andheri-Kurla Road, Andheri (East), Mumbai, Maharashtra -400059

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Noctaderm Cream

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Noctaderm Cream

Benefits of Noctaderm Cream

Side effects of Noctaderm Cream

How to use Noctaderm Cream

How Noctaderm Cream works

All substitutes for Noctaderm Cream

Galdopin Cream

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Hydroxyzine (Oral Route)

Procarbazine (Oral Route)

Domperidone (Oral Route)

Sertraline (Oral Route)

Frequently asked questions

What is Noctaderm Cream used for?

What are the side effects of Noctaderm Cream?

How does it help to relieve itching?

How to use Noctaderm Cream?

What precautions do I need to take while using Noctaderm Cream?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

What are you using Noctaderm Cream for?

How much was the improvement?

What were the side-effects while using Noctaderm Cream?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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