Nitroplus 25mg Injection

Prescription Required
SALT COMPOSITION
Salt Synonyms
Storage
Store at room temperature (10-30°C)

Introduction

Nitroplus 25mg Injection is used to treat and prevent heart-related chest pain (angina). Angina occurs when the heart muscle is not getting enough blood. This medicine works by relaxing and widening blood vessels so blood can flow more easily to the heart. It has a very short-lived effect.

Nitroplus 25mg Injection is given as an injection under the supervision of a doctor with careful blood pressure monitoring. This is given as a continuous infusion into a vein and should not be stopped abruptly. It should not be mixed with any other medication of any kind.

The most common side effect of Nitroplus 25mg Injection is a headache which may be severe. This can sometimes be helped by drinking plenty of fluids and avoiding alcohol. You may also experience lightheadedness, which could increase your risk of having a fall. There are other, rarer side effects, some of them serious. Ask your doctor and read the leaflet which comes with the medicine to make sure you are keeping safe.

Do not use Nitroplus 25mg Injection if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or erectile dysfunction; or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. It is best not to drink alcohol with this medicine as it increases some of the side effects. If you are affected by dizziness, avoid driving. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine.

Uses of Nitroplus Injection

Benefits of Nitroplus Injection

In Treatment and prevention of Angina (heart-related chest pain)

Nitroplus 25mg Injection helps in prevention as well as treatment of angina. Angina is a chest pain that is usually caused by narrowing of the blood vessels which supply your heart. This means your heart does not get enough oxygen. Nitroplus 25mg Injection relaxes and widens the blood vessels so more blood (and oxygen) gets to your heart. This reduces the pain and discomfort that angina causes thereby improving your ability to exercise and go about your daily life more easily. It is given as an injection under the supervision of a doctor.

Side effects of Nitroplus Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nitroplus

  • Headache

How to use Nitroplus Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nitroplus Injection works

Nitroplus 25mg Injection is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain).

Safety Advice

Alcohol
UNSAFE
Consuming alcohol while taking Nitroplus 25mg Injection may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
SAFE IF PRESCRIBED
Nitroplus 25mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breastfeeding
SAFE IF PRESCRIBED
Nitroplus 25mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Nitroplus 25mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Nitroplus 25mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nitroplus 25mg Injection may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Nitroplus 25mg Injection in patients with liver disease. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • It is given via a drip into a vein under the supervision of a doctor.
  • It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
  • Nitroplus 25mg Injection may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
  • Do not consume alcohol while taking Nitroplus 25mg Injection as it may cause increased dizziness.
  • Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Nitroplus 25mg Injection as it may cause low blood pressure.

Fact Box

Chemical Class
Nitrates {Short acting}
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
NO Donors

Interaction with Drugs

Taking Nitroplus with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Joy On, One Up, Confidence
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Brand(s): Suvida Force, Tadagra, Tadafun
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Brand(s): Udzire
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Brand(s): Edafil
LIFE-THREATENING

Patient Concerns

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What is heart attack? When heart attack coming?
Dr. Nabajit Talukdar
Cardiology
Related to chest pain angina commonly
Chest pain headache vetrigo Angina pain
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Cardiology
Get echo n ECG done
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Do you have any questions related to Nitroplus 25mg Injection ?

FAQs

Q. Does the effect of Nitroplus 25mg Injection wear off after sometime?

Yes, excessive use of Nitroplus 25mg Injection may cause tolerance which means that Nitroplus 25mg Injection may lose its effectiveness on you. Therefore, doctors usually prescribe the smallest dose required for effective relief of acute angina attacks. Also, it is usually prescribed in morning and afternoon doses to give nitrate-free interval. Take it strictly as per the dosing interval prescribed by your doctor to prevent tolerance and maintain the effectiveness of Nitroplus 25mg Injection.

Q. What effect does Nitroplus 25mg Injection have on blood pressure?

Nitroplus 25mg Injection slightly decreases the blood pressure by relaxing the blood vessels, but is not recommended for the treatment of high blood pressure. The drop in blood pressure may cause lightheadedness, especially when changing your position suddenly. You should avoid sudden change in your position, for eg, get up slowly if you are sitting or lying down, to minimise this side effect.

Q. What does too much Nitroplus 25mg Injection do?

Excess Nitroplus 25mg Injection may result in low blood pressure, sweating, nausea, vomiting, headache, weak and fast pulse. It may also cause weakness, lightheadedness on standing and the patient might even faint. The patient will require emergency medical treatment in such a case.

Q. Does Nitroplus 25mg Injection stop heart attacks?

Nitroplus 25mg Injection is prescribed to prevent attacks of heart-related chest pain (angina) in patients with coronary artery disease. In this disease, the blood vessels (coronary arteries) which supply blood to the heart become narrow because of which the heart has to work harder to get enough oxygen. Nitroplus 25mg Injection prevents angina by relaxing the blood vessels so that the heart does not have to work very hard. Also, relaxation of coronary arteries increases the oxygen supply to the heart.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 747-55.
  2. Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 191, 195-97.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 986-88.
  4. Nitroglycerin [FDA Label]. Deerfield, IL: Baxter Healthcare Corporation; 2014. [Accessed 15 Nov. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Nitroglycerin. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Country of Origin: India

Expires on or after: July, 2021

A licensed vendor partner from your nearest location will deliver Nitroplus 25mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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