Tadalafil

Information about Tadalafil

Tadalafil uses

Tadalafil is used in the treatment of erectile dysfunction and pulmonary hypertension.
It is also used in erectile dysfunction with benign prostatic hyperplasia (enlarged prostate).

How tadalafil works

Tadalafil increases blood flow to the penis by relaxing the muscles in penile blood vessels. It helps to get an erection only if the person is sexually stimulated.

Common side effects of tadalafil

Headache, Nausea, Nasopharyngitis, Flushing (sense of warmth in the face, ears, neck and trunk), Dyspepsia, Muscle pain, Back pain, Pain in extremity.

Available Medicine for Tadalafil

  • ₹142 to ₹269
    Macleods Pharmaceuticals Pvt Ltd
    2 variant(s)
  • ₹32 to ₹1339
    Dr Reddy's Laboratories Ltd
    6 variant(s)
  • ₹150
    Mankind Pharma Ltd
    1 variant(s)
  • ₹162
    Sun Pharmaceutical Industries Ltd
    1 variant(s)
  • ₹288
    Cipla Ltd
    1 variant(s)
  • ₹141
    Fourrts India Laboratories Pvt Ltd
    1 variant(s)
  • ₹39 to ₹390
    Fourrts India Laboratories Pvt Ltd
    3 variant(s)
  • ₹106 to ₹170
    Icon Life Sciences
    2 variant(s)
  • ₹83 to ₹187
    Zydus Cadila
    3 variant(s)
  • ₹96 to ₹165
    Ipca Laboratories Ltd
    2 variant(s)

Expert advice for Tadalafil

  • Tadalafil helps to have and maintain an erection, but it will not produce the erection without sexual stimulation.
  • It should be taken one hour before sexual intercourse.
  • Inform your doctor if the erection does not subside within two hours after sexual intercourse.
  • Inform your doctor if you experience any eye sight change while taking Tadalafil.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.

Frequently asked questions for Tadalafil

Tadalafil

Q. Is tadalafil addictive?
No, tadalafil is not an addictive drug. However, some people may develop an emotional or psychological dependence on the medicine. Always take the medicine for the duration as suggested by your doctor.
Q. Can I take tadalafil with prednisone?
Tadalafil, when taken with prednisone, may cause low blood pressure. Please consult your doctor for the change of dose regimen or an alternative drug of choice that may be required when the two medicines are to be used together.
Q. Is tadalafil safe to use?
Tadalafil is safe when used strictly as advised by your doctor and for approved conditions like erectile dysfunction and pulmonary arterial hypertension. However, there are some very common side effects that you may experience with tadalafil like a headache, flushing, nasal congestion, dyspepsia, back pain, muscle pain, and pain in extremity.
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Q. Is tadalafil better than sildenafil?
Both tadalafil and sildenafil belong to the same group of drugs called phosphodiesterase 5 inhibitors, used for the treatment of erectile dysfunction and pulmonary arterial hypertension. However, tadalafil has a slow onset of action with less efficacy but works for a much longer time and is safer than sildenafil.
Q. How long can I take tadalafil for?
Tadalafil should only be taken only for the time period as advised by your doctor.
Q. Can I take tadalafil with losartan?
Yes, tadalafil can be taken with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.
Q. Can I take tadalafil if I have high blood pressure?
Tadalafil can be taken in patients with high blood pressure. However, if you are on medicines for high blood pressure, taking tadalafil along with them can cause a significant fall in blood pressure which could be harmful. Tadalafil is absolutely contraindicated in patients taking nitrates. Inform your doctor before taking them together.
Q. Can I take tadalafil with antibiotics?
Tadalafil can be taken safely with antibiotics. However, it is degraded in the body by an enzyme known as CYP3A4 and a dose adjustment may be needed when it is used with drugs which can affect the activity of this enzyme. Antibiotics like erythromycin, clarithromycin, ketoconazole and itraconazole can decrease the action of this enzyme and increase tadalafil levels in the blood. Antibiotics like rifampicin increase the action of this enzyme causing an increased breakdown of tadalafil and decrease its efficacy.
Q. Does tadalafil affect sperm count?
No, tadalafil has no known effect on sperm count. It is a medication used for erectile dysfunction, not to increase sperm count.
Q. Does tadalafil delay ejaculation?
No, tadalafil is not known to affect ejaculation. It is used for the treatment of erectile dysfunction.
Q. Does tadalafil expire?
Like any other drug, tadalafil does have an expiry date and should not be used beyond that. Please check the package insert for the same.
Q. Does tadalafil work?
Yes, tadalafil works very effectively for the treatment of erectile dysfunction and pulmonary arterial hypertension when taken strictly as advised by your doctor.
Q. How long does tadalafil last?
Generally, the effect of tadalafil lasts from 24 to 36 hours, however, the effect may vary from patient to patient. As it works for a long duration, its action may last for more than one day. Some patients call it a weekend pill which is when taken on Friday night, the effect may last until Sunday morning. So it is preferred over sildenafil and verdanafil by some patients.
Q. Is tadalafil a steroid?
No, tadalafil is not a steroid. It is a phosphodiesterase enzyme inhibitor and is used for treating erectile dysfunction.
Q. Is tadalafil same as sildenafil?
Both tadalafil and sildenafil belong to the same group of drugs called phosphodiesterase 5 inhibitors, used for the treatment of erectile dysfunction and pulmonary arterial hypertension. However, tadalafil has a slow onset of action with less efficacy but works for a much longer time and is safer than sildenafil.
Q. Can I take tadalafil forever?
No, tadalafil is not a life long medicine. It should be taken only for a duration as advised by the doctor.
Q. Can I take tadalafil just for fun?
Tadalafil is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with many side effects. Also, it is available only on prescription by a doctor.
Q. Can I take tadalafil with tamsulosin?
When taken together, these drugs may produce an additive blood-pressure-lowering effect. Dose needs to be titrated carefully. Consult your doctor before taking them together.
Q. Can I take tadalafil with lisinopril?
Yes, tadalafil can be taken with lisinopril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.
Q. Can I take tadalafil with metoprolol?
Yes, tadalafil can be taken with metoprolol. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.
Q. Does tadalafil cure erectile dysfunction?
Tadalafil is not a cure for erectile dysfunction. It produces an erection by relaxing penile smooth muscles and increasing blood flow.
Q. Does tadalafil increase the size of the penis?
No, tadalafil is not known to increase the size of the penis.
Q. Does tadalafil lower blood pressure?
Tadalafil can lower the blood pressure but does not have a significant effect. However, when used along with other medications which lower blood pressure, it can have an additional effect which can be harmful. Talk to your doctor in case you are taking blood pressure lowering medicines and you are also advised to take tadalafil.
Q. Does tadalafil increase testosterone?
Tadalafil is not known to have any effect on testosterone levels. However, if your testosterone levels are low, then tadalafil may not be useful in treating erectile dysfunction.
Q. Can I take tadalafil with sildenafil?
Both tadalafil and sildenafil are phosphodiesterase inhibitors and act by dilating the blood vessels. Using them together would not give any additional benefit, rather they may cause a severe fall in blood pressure and a prolonged painful erection. Therefore, these two drugs should not be taken together.
Q. How long does tadalafil take to show its effect?
Tadalafil starts to work very fast and it takes around 20 minutes to show its effect. Its action stays for 24 to 36 hours (maximum of 72 hours).
Q. Can I take tadalafil when I am also taking bisoprolol?
Yes, Tadalafil can be taken with bisoprolol. However, there could be an excessive fall in blood pressure when they are taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. What will be the effect of using ibuprofen with tadalafil?
Yes, tadalafil can be taken with ibuprofen. It is used by many patients to relieve the headache caused by tadalafil. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Is tadalafil use associated with nosebleed (epistaxis)?
Yes, there have been some reports where the patients have given the history of nose bleed (epistaxis) after taking tadalafil. Other drugs from the same class have also shown to cause nose bleeds in some patients.
Q. What is the difference between tadalafil and L-arginine?
Tadalafil is used for the treatment of erectile dysfunction. It works by releasing nitrous oxide (NO) which relaxes the smooth muscles of the blood vessels and dilates them. L-arginine is an amino acid which is involved in the synthesis of nitric oxide (NO). So, it has been suggested that L-arginine can help in the treatment of erectile dysfunction. However, there is no regulatory approval for its use as of now.
Q. Are tadalafil and avanafil same?
No, tadalafil and avanafil are not same drugs but they belong to the same class of phosphodiesterase-5 (PDE5) inhibitors used for the treatment of erectile dysfunction. Tadalafil is also used in the treatment of pulmonary arterial hypertension in lower doses. Tadalafil is seen to be more efficacious, better tolerated and longer acting than avanafil. However, avanafil starts to show its effect faster than tadalafil.
Q. How is tadalafil different from vardenafil?
Both tadalafil and vardenafil are phosphodiesterase-5 (PDE5) inhibitors used in the treatment of erectile dysfunction (ED). Tadalafil is also used in the treatment of pulmonary arterial hypertension in lower doses. Tadalafil starts to act in 20 minutes but the action remains for almost 36 hours whereas vardenafil starts to act in 10 minutes and acts for almost 10 hours, respectively. Tadalafil is less effective than vardenafil but safer.
Q. Is it safe to take tadalafil with amlodipine?
Yes, tadalafil can be taken with amlodipine. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.
Q. Is it safe to take tadalafil with propranolol?
Yes, tadalafil can be taken with propranolol. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.
Q. Can I take tadalafil when I am also taking atenolol for controlling my blood pressure?
Yes, tadalafil can be taken with atenolol. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.
Q. Is it safe to take tadalafil when I am also taking fluconazole?
Tadalafil can be taken with fluconazole, however, a dose adjustment would be needed before taking them together. Tadalafil is metabolized (degraded) by an enzyme known as CYP3A4. Fluconazole decreases the working of this enzyme causing increased blood levels of Tadalafil and higher chances of having side effects.
Q. Is tadalafil safe to use in patients with glaucoma?
Yes, tadalafil can be used by patients with glaucoma. But you must inform your doctor before using this medicine. It has been found to increase the intraocular pressure in animals whereas the same is not seen in humans. However, other medicines of this class have been reported to cause increase intraocular pressure in healthy human beings.
Q. Is it safe to take tadalafil with dapoxetine?
Yes, tadalafil can be safely taken with dapoxetine. Tadalafil is useful for treating erectile dysfunction and dapoxetine is for premature ejaculation. A fixed dose combination of these medicines is available which is useful in patients suffering from both erectile dysfunction and premature ejaculation. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I use tadalafil with nitroglycerin?
Use of tadalafil is not recommended in patients taking nitrates like nitroglycerin as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of tadalafil and any nitrate substance.
Q. What is the benefit of taking tadalafil with finasteride?
Yes, tadalafil can be taken along with finasteride. This combination is beneficial in the treatment of benign prostatic hyperplasia (BPH). Finasteride is also known to cause erectile dysfunction as one of its side effects and tadalafil can be used for the treatment of this problem along with finasteride.
Q. Can I take tadalafil with grapefruit juice?
Tadalafil can be taken with grapefruit juice, however, a dose adjustment would be needed before taking them together. Tadalafil is metabolized (degraded) by an enzyme known as CYP3A4. Grapefruit juice decreases the working of this enzyme causing increased blood levels of tadalafil and which can cause higher chances of having side effects.
Q. Can I take tadalafil with tramadol?
Yes, tadalafil can be taken with tramadol. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. How safe is it to use tadalafil with paracetamol?
Yes, tadalafil can be taken with paracetamol. It is used by many patients to relieve a headache caused by tadalafil. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Is Tadalafil a nitrate?
No, Tadalafil is not a nitrate. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.
Q. Is Tadalafil a controlled substance?
Tadalafil is not a controlled substance. It's a prescription medicine and is available on providing a valid prescription by a doctor.
Q. Is Tadalafil a blood thinner?
No, Tadalafil is not a blood thinner. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.
Q. Is tadalafil a prescription medicine?
Yes, Tadalafil is a prescription medicine. It is available for providing a valid prescription by a doctor.

Content on this page was last updated on 19 June, 2017, by Dr. Varun Gupta (MD Pharmacology)