Monocin 100mg Injection

Rifampicin (100mg)

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Monocin 100mg Injection is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. It may be used alone or in combination with other medicines to fight serious infections.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 12 Jul 2026 | 01:02 AM (IST)

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General Information

Contains

Rifampicin (100mg)

Marketer

Maan Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Monocin 100mg Injection medicine may also be given to people who are carriers (people who are infected, yet do not show any signs and symptoms of infection). It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. It should be used regularly as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping this injection too early may lead to the infection returning or worsening.

Some people may develop side effects like low blood platelets, headache, dizziness, vomiting, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away.

Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests for liver function test while using Monocin 100mg Injection.

Uses of Monocin Injection

Tuberculosis (TB)

Benefits of Monocin Injection

Tuberculosis (TB)
Monocin 100mg Injection is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection-causing bacteria and helps in treating the infection. It is given as an injection by a doctor or nurse and should not be self-administered. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Monocin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Monocin

Low blood platelets
Dizziness
Vomiting
Nausea
Fever
Abdominal pain
Skin rash
Hepatitis (viral infection of liver)
Headache
Chills
Paradoxical reactions
Increased aspartate aminotransferase
Increased alanine aminotransferase
Increased bilirubin in the blood

How to use Monocin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Monocin Injection works

Monocin 100mg Injection is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Quick tips

Your doctor has prescribed Monocin 100mg Injection to cure your infection and improve symptoms.
Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
Tell your doctor about all other medicines you are taking as Monocin 100mg Injection can interact with many medicines.
Avoid taking hormone-based birth control methods as Monocin 100mg Injection may decrease their effectiveness.
Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Monocin 100mg Injection

Pregnancy

CONSULT YOUR DOCTOR

The safety of Monocin 100mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Monocin 100mg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Monocin 100mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Monocin 100mg Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Monocin 100mg Injection in patients with liver disease.

Interaction with drugs

Taking Monocin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Acalabrutinib (Oral Route)

Do not consume Acalabrutinib with Rifampicin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Rifampicin may reduce blood levels of Acalabrutinib.

Severe

Darunavir (Oral Route)

Do not consume Darunavir with Rifampicin. Rifampicin may reduce blood levels and efficacy of Darunavir.

Severe

Sofosbuvir (Oral Route)

Do not consume Sofosbuvir with Rifampicin. Rifampicin may reduce blood levels and efficacy of Sofosbuvir.

Severe

Allylestrenol (Oral Route)

Use other methods of contraception (IUDs, depot or barrier methods) both during and for 28 days following the discontinuation of Rifampicin. Rifampicin may reduce the efficacy of Allylestrenol.

Severe

Saquinavir (Oral Route)

Do not consume Saquinavir with Rifampicin. If concurrent use is essential, please consult your doctor. Rifampicin may reduce blood levels and efficacy of Saquinavir.

Frequently asked questions

Is rifampin a penicillin/amoxicillin/sulfa drug?

No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs

Is rifampin bacteriostatic or bactericidal?

Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria

Is rifampin an inducer or inhibitor?

Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

What is R-cin 600 used for?

R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections

What is R-cinex/Macox plus/R-cinex 600?

R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid

Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections

Does rifampin cause headaches?

Yes. Headache is a possible side effect of rifampin

Does rifampin change urine color/turn urine orange?

Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful

Does rifampin cause liver damage?

Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

RNA polymerase inhibitors- Rifamycins

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1213-14.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Maan Pharmaceuticals Ltd
Address: Plot No 1, Gidc, Phase 2, Modhera Road, Modhera, Mehsana - 384212

Vendor Details

Country of origin: India

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Monocin 100mg Injection

Monocin 100mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Monocin Injection

Benefits of Monocin Injection

Side effects of Monocin Injection

How to use Monocin Injection

How Monocin Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Acalabrutinib (Oral Route)

Darunavir (Oral Route)

Sofosbuvir (Oral Route)

Allylestrenol (Oral Route)

Saquinavir (Oral Route)

Frequently asked questions

Is rifampin a penicillin/amoxicillin/sulfa drug?

Is rifampin bacteriostatic or bactericidal?

Is rifampin an inducer or inhibitor?

What is R-cin 600 used for?

What is R-cinex/Macox plus/R-cinex 600?

Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?

Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?

Does rifampin cause headaches?

Does rifampin change urine color/turn urine orange?

Does rifampin cause liver damage?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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