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Sofosbuvir

INFORMATION

Uses

Sofosbuvir is used in the treatment of chronic hepatitis C .

How it works

Sofosbuvir is an antiviral drug that belongs to a class of medicines called nucleotide polymerase inhibitors. It inhibits an enzyme RNA polymerase which is essential for viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function.

Common side effects

Nausea, Pale colored skin, Back pain, Chills, Diarrhoea, Fatigue, Weakness, Fever, Headache, Insomnia, Loss of appetite, Mouth ulcer, Muscle pain, Muscle cramp, Rash, Itching, Sores, Ulcer

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Expert advice

  • This drug should be used only in combination with Ribavirin or with Pegylated interferon and Ribavirin.
  • Treatment with sofosbuvir is not recommended in patients with severe kidney or liver problems or depression.
  • Do consult your doctor if you are taking amiodarone (used for serious irregular heartbeats). The risk of slow heartbeat may be increased when taken along with Sofosbuvir.
  • Take extreme care to avoid pregnancy in female patients or female partners of male patients who are on treatment with sofosbuvir.
  • Take necessary precautions as sofosbuvir does not prevent the spread of infection to other people through sexual contact, sharing needles, or contact with blood.

Frequently asked questions

Sofosbuvir

Q.Is Sofosbuvir a protease inhibitor?
No. Sofosbuvir is a nucleotide polymerase inhibitor

Q.How does Sofosbuvir work?
Sofosbuvirstops viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function

Q.Does Sofosbuvir cure Hepatitis C?
Sofosbuvir is used to treat Hepatitis C virus infection. The treatment response with Sofosbuvir (in conjunction with other drugs) varies based on baseline host and viral factors.


Content on this page was last updated on 15 October, 2016, by Dr. Varun Gupta (MD Pharmacology)