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Mesacol 500mg Suppository

Mesalazine (500mg)

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Mesacol 500mg Suppository is a medicine used to treat Crohn’s disease and ulcerative colitis. It is used when the lining tissue of the inner rectum becomes inflamed (proctitis). It helps to reduce symptoms such as diarrhea, bleeding, and stomach pain by reducing inflammation in the bowel.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 23 Jan 2026 | 10:15 AM (IST)

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Mesacol 500mg Suppository is only for the rectal route and should not be taken orally. It must be used under the supervision of a doctor or healthcare professional. Stay in a lying position for at least 15 minutes after the insertion of suppositories. The dose will depend on what you are being treated for, but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen.

The most common side effects of this medicine include rectal discomfort, rash, itching, and fever. If these symptoms bother you or do not go away or get worse, tell your doctor. There may be ways of reducing or preventing them.

Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking, as some may affect or be affected by this medicine. You may be asked for kidney and liver function tests before and after the treatment.

Uses of Mesacol Suppository

Benefits of Mesacol Suppository

Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the colon and rectum. Mesacol 500mg Suppository helps reduce the inflammation in the intestinal lining by targeting the disease locally. Reduction in inflammation promotes mucosal healing and causes symptoms like abdominal pain, diarrhea, and rectal bleeding to subside.

Crohn’s disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, causing symptoms like abdominal pain, diarrhea, and fatigue. Mesacol 500mg Suppository is used in mild to moderate cases to reduce inflammation and manage flare-ups. It can help prevent disease progression, reduce the need for steroids, and support intestinal health over time.

Side effects of Mesacol Suppository

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mesacol

Flatulence
Headache
Diarrhea
Nausea
Rectal discomfort
Abdominal pain
Vomiting
Rash

How to use Mesacol Suppository

Remove the wrapper from the suppository before inserting it. Keep lying down for about 15 minutes after insertion so that the suppository does not come out before it melts.

How Mesacol Suppository works

Mesacol 500mg Suppository is an aminosalicylate. It works directly on the site of inflammation (swelling) in the lower parts of the large intestine (colon and rectum) to provide rapid relief from attacks of ulcerative colitis. It suppresses the production of chemical messengers (prostaglandins) that cause intestinal inflammation, thereby reducing ulceration, bleeding, and painful symptoms.

Quick tips

Mesacol 500mg Suppository is for administration into the back passage (rectum). It must not be taken by mouth.
Avoid taking antacids with Mesacol 500mg Suppository as it can make your inflammation worse.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Mesacol 500mg Suppository during pregnancy is not available. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Mesacol 500mg Suppository may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
If you are taking Mesacol 500mg Suppository, monitor the baby for diarrhea.

Driving

No interaction found/established

Kidney

UNSAFE

Mesacol 500mg Suppository is unsafe to use in patients with kidney disease and should be avoided.
Use of Mesacol 500mg Suppository is not recommended in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Mesacol 500mg Suppository in patients with liver disease.

Interaction with drugs

Taking Mesacol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Azathioprine (Oral Route)

If concurrent use is essential, your doctor may monitor blood cell counts and your overall treatment closely.

Moderate

Mercaptopurine (Oral Route)

If concurrent use is essential, your doctor may monitor blood cell counts and your overall treatment closely.

Moderate

Deferiprone (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.

Mild

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Frequently asked questions

My symptoms have improved can I stop using Mesacol 500mg Suppository?

Continue to use Mesacol 500mg Suppository as advised by the doctor, even if you feel better at the beginning of your treatment. Do not stop using Mesacol 500mg Suppository without consulting your doctor.

I am suffering from ulcerative colitis (UC) and piles can I use Mesacol 500mg Suppository?

Mesacol 500mg Suppository is used for the treatment of ulcerative colitis; however, you should not start using the medicine on your own. Consult a doctor who will prescribe you the right dose and duration of treatment and will address any related or other concerns that you have.

Can I drink alcohol while using Mesacol 500mg Suppository?

You should avoid alcohol if you have ulcerative colitis, as alcohol will irritate your stomach and intestines, which will worsen your condition. Although alcohol does not interfere with the working of Mesacol 500mg Suppository, you should consult your doctor before using alcohol.

What is the best time to use Mesacol 500mg Suppository?

Use Mesacol 500mg Suppository exactly as directed by your doctor. If you are using Mesacol 500mg Suppository suppositories, you should insert them rectally, once daily at bedtime.

Fact Box

Chemical Class

Aminobenzoic acids

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

5-Aminosalicylic Acid (5-ASA)

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 867-69.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Mesalamine. [Updated 2019 Apr 1]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Mesalazine [Product Information]. Pymble, NSW: Ferring Pharmaceuticals Pty Ltd.; 2023. [Accessed 11 Jul. 2023]. (online) Available from:
Mesalazine [New Zealand Data Sheet]. Mt Wellington, Auckland: Pharmaco (NZ) Ltd.; 2023. [Accessed 11 Jul. 2023]. (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Mesacol 500mg Suppository. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Mesacol 500mg Suppository

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Mesacol Suppository

Benefits of Mesacol Suppository

Side effects of Mesacol Suppository

How to use Mesacol Suppository

How Mesacol Suppository works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Azathioprine (Oral Route)

Mercaptopurine (Oral Route)

Deferiprone (Oral Route)

Clozapine (Oral Route)

Frequently asked questions

My symptoms have improved can I stop using Mesacol 500mg Suppository?

I am suffering from ulcerative colitis (UC) and piles can I use Mesacol 500mg Suppository?

Can I drink alcohol while using Mesacol 500mg Suppository?

What is the best time to use Mesacol 500mg Suppository?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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