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Mannitol IV 20% Injection

Mannitol (20% w/v)

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Mannitol IV 20% Injection is a medicine used in the treatment of acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain) and to reduce the pressure inside the eyes in a condition called glaucoma.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)

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100 ml Injection

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General Information

Contains

Mannitol (20% w/v)

Marketer

Abbott

The content is shown in English

Product introduction

Mannitol IV 20% Injection works by removing excess water and also relieves inflammation in the affected areas. It may be used alone or in combination with other medicines. It is administered as an injection under the supervision of a medical professional and should not be self administered. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember.

Some common side effects of this medicine include nausea, vomiting, headache, and dehydration. You may also notice some injection site reactions such as pain, redness or swelling. However, these are temporary and usually subside on their own after some time. Please consult your doctor if these do not subside or bother you. Regular monitoring by blood tests may be required while using this medicine.

Uses of Mannitol IV Injection

Glaucoma
Acute renal failure
Cerebral edema (accumulation of excessive fluid in the brain)

Benefits of Mannitol IV Injection

Glaucoma
Mannitol IV 20% Injection is used in glaucoma to rapidly lower eye pressure, providing relief from pain and helping prevent vision loss during acute episodes.

Acute renal failure
In acute renal failure, Mannitol IV 20% Injection supports urine production and helps flush out toxins, aiding in kidney function recovery.

Cerebral edema (accumulation of excessive fluid in the brain)
Mannitol IV 20% Injection helps reduce swelling in the brain by drawing excess fluid away, relieving pressure and lowering the risk of complications from brain injuries or conditions.

Side effects of Mannitol IV Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mannitol IV

Nausea
Vomiting
Headache
Dehydration
Injection site reactions (pain, swelling, redness)

How to use Mannitol IV Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mannitol IV Injection works

Mannitol IV 20% Injection is an inert substance with high osmotic pressure. It draws water into the kidney, which in turn increases the amount of urine production. Mannitol IV 20% Injection is also used to lower the pressure inside the eye or swelling around the brain.

Quick tips

It is given as an injection into the veins by a doctor or healthcare professional.
Your doctor may get regular blood tests done to monitor sodium and potassium level, kidney function, and lung function while you are taking this medicine.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
It is given as an injection into the veins by a doctor or healthcare professional.
Your doctor may get regular blood tests done to monitor sodium and potassium level, kidney function, and lung function while you are taking this medicine.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Mannitol IV 20% Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Mannitol IV 20% Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Mannitol IV 20% Injection during breastfeeding is not available. Please consult your doctor.

Driving

NOT RELEVANT

Not relevant, as Mannitol IV 20% Injection is intended for use in hospitalized patients.

Kidney

CAUTION

Mannitol IV 20% Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Mannitol IV 20% Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Mannitol IV with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tobramycin (Injection Route)

Do not consume Tobramycin with Mannitol. If concurrent use is essential, your doctor may monitor your kidney function closely.

Severe

Tobramycin (Inhalation Route)

Do not consume Tobramycin with Mannitol. If concurrent use is essential, your doctor may monitor your kidney function closely.

Severe

Tobramycin (Oral Route)

Do not consume Tobramycin with Mannitol. If concurrent use is essential, your doctor may monitor your kidney function closely.

Moderate

Lamivudine (Oral Route)

Do not consume Lamivudine with Mannitol. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Mannitol may reduce blood levels of Lamivudine.

Moderate

Atracurium (Injection Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required. Mannitol may increase the effect of Atracurium.

Frequently asked questions

What is Mannitol IV 20% Injection used for?

Mannitol IV 20% Injection is used to help remove extra fluid from your body. It is often given in hospitals to reduce pressure in the brain (after injury or surgery) or in the eyes (like in glaucoma). It can also help your kidneys produce urine when they are not working well and help flush out certain poisons from the body.

Who should not receive Mannitol IV 20% Injection?

Individuals should not receive Mannitol IV 20% Injection if they have severe kidney problems, heart failure, lung congestion, severe dehydration, or active bleeding inside the brain (except during surgery). It should also be avoided if the individual is allergic to mannitol.

Is Mannitol IV 20% Injection safe for people with kidney problems?

Mannitol IV 20% Injection should be used with great care if your kidneys are not working well. Your doctor may give a small test dose first to check if your kidneys can handle it. If you stop passing urine or your kidney function worsens, the treatment is usually stopped immediately.

Can Mannitol IV 20% Injection cause brain swelling or confusion?

In some people, Mannitol IV 20% Injection can cross into the brain and cause confusion, drowsiness, or even worsen swelling in certain cases, especially if the protective barrier between the brain and blood is damaged. Your doctor will monitor you closely to avoid this.

What serious side effects of Mannitol IV 20% Injection should I watch for?

Serious side effects of Mannitol IV 20% Injection may include difficulty breathing, chest pain, confusion, reduced urination, or swelling in your feet. These can be signs of fluid overload, heart failure, or kidney problems, which require medical attention.

Why is Mannitol IV 20% Injection used to lower pressure in the brain and eyes?

Mannitol IV 20% Injection helps draw excess fluid out of tissues into the bloodstream, reducing swelling and pressure in the brain and eyes. It is commonly used in emergencies like head injury, stroke, or glaucoma when other treatments are not enough.

Can Mannitol IV 20% Injection affect my body’s water and salt balance?

Yes, Mannitol IV 20% Injection can change your body’s water and electrolyte levels, sometimes leading to dehydration, high or low sodium, or acid‑base imbalance. Doctors check your blood and urine regularly to keep this in control.

What happens if Mannitol IV 20% Injection builds up in the body?

If Mannitol IV 20% Injection is not removed properly by the kidneys, it can build up, causing too much fluid in the body, swelling, or even worsening heart or kidney problems. That is why it is given under close hospital supervision.

Can Mannitol IV 20% Injection affect people with heart problems?

Yes, Mannitol IV 20% Injection can cause too much fluid in the bloodstream, which may worsen heart failure or cause lung congestion. Doctors will check your heart condition carefully before giving it.

Why do doctors monitor urine output closely during Mannitol IV 20% Injection?

Urine output helps doctors know if your kidneys are removing Mannitol IV 20% Injection effectively. Low or no urine during treatment may mean your kidneys are not tolerating it, and the infusion might need to be stopped.

Is Mannitol IV 20% Injection safe for older adults or children?

Older adults and children may be more sensitive to fluid or electrolyte imbalances caused by Mannitol IV 20% Injection. The dose is adjusted carefully based on age, weight, and medical condition.

Fact Box

Chemical Class

Sugar alcohols

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Osmotic Diuretics

Related lab tests

Blood Urea Nitrogen

Creatinine - Spot

Kidney Function Test

Sodium

Urine Routine & Microscopy

References

Ives HE. Diuretic Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 263.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 836-37.
Mannitol. Thetford, Norfolk: Baxter Healthcare Ltd.; 2003 [revised Jan. 2017]. [Accessed 25 Mar 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Mannitol IV 20% Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Mannitol IV 20% Injection

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General Information

Contains

Marketer

Product introduction

Uses of Mannitol IV Injection

Benefits of Mannitol IV Injection

Side effects of Mannitol IV Injection

How to use Mannitol IV Injection

How Mannitol IV Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tobramycin (Injection Route)

Tobramycin (Inhalation Route)

Tobramycin (Oral Route)

Lamivudine (Oral Route)

Atracurium (Injection Route)

Frequently asked questions

What is Mannitol IV 20% Injection used for?

Who should not receive Mannitol IV 20% Injection?

Is Mannitol IV 20% Injection safe for people with kidney problems?

Can Mannitol IV 20% Injection cause brain swelling or confusion?

What serious side effects of Mannitol IV 20% Injection should I watch for?

Why is Mannitol IV 20% Injection used to lower pressure in the brain and eyes?

Can Mannitol IV 20% Injection affect my body’s water and salt balance?

What happens if Mannitol IV 20% Injection builds up in the body?

Can Mannitol IV 20% Injection affect people with heart problems?

Why do doctors monitor urine output closely during Mannitol IV 20% Injection?

Is Mannitol IV 20% Injection safe for older adults or children?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Blood Urea Nitrogen

Creatinine - Spot

Kidney Function Test

Sodium

Urine Routine & Microscopy

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests