Lupiximab 500mg Injection

Prescription Required
Manufacturer
SALT COMPOSITION
Storage
Store in a refrigerator (2 - 8°C). Do not freeze.

Introduction

Lupiximab 500mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis.

Lupiximab 500mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Before taking it, tell your doctor if you have heart disease, liver, or planning surgery or vaccination or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Lupiximab Injection

Benefits of Lupiximab Injection

In Non-Hodgkin lymphoma (NHL)

Non-Hodgkin's lymphoma is a cancer of the white blood cells in our body, also called mantle-cell lymphoma. White blood cells are those cells that help us to fight infections. Lupiximab 500mg Injection lowers immune response and helps to reduce pain and inflammation. It also kills the cancer cells and helps prevent their further growth. Avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to.

In Rheumatoid arthritis

Lupiximab 500mg Injection helps treat inflammation, pain and swelling in rheumatoid arthritis by decreasing the immune system response of the patient. It is given in the dose and frequency that suits your condition. This will be decided by the doctor. You must follow your doctor’s instructions carefully and let your doctor know if you have fever, chills or any bothersome side effects after taking this medicine.

In Blood cancer (Chronic lymphocytic leukemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Lupiximab 500mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but you should discuss the side effects and benefits of this medicine with your doctor. Let your doctor know if any of the side effects bothers you.

In Granulomatosis with polyangiitis

Granulomatosis with polyangiitis is a condition that causes inflammation of the blood vessels of the ears, nose, throat, lungs, and kidneys. In this condition, the blood flow to these areas may be reduced and it can lead to their damage. Lupiximab 500mg Injection helps reduce inflammation, pain and swelling and prevents further damage. This improves your quality of life.

In Microscopic polyangiitis

Microscopic polyangiitis is an autoimmune disease which occurs in the small blood vessels and may be caused due to problems with the immune system. Lupiximab 500mg Injection reduces immune response and improves inflammation. This helps to heal this condition and improves your discomfort.

Side effects of Lupiximab Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lupiximab

  • Headache
  • Weakness
  • Edema (swelling)
  • Infection
  • Hair loss
  • Itching
  • Chills
  • Febrile neutropenia
  • Decreased white blood cell count (neutrophils)
  • Infusion reaction
  • Increased risk of infection
  • Decreased blood cells (red cells, white cells, and platelets)

How to use Lupiximab Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Lupiximab Injection works

Lupiximab 500mg Injection is a monoclonal antibody. It works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis and certain types of cancers.

Safety Advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Lupiximab 500mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Lupiximab 500mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Lupiximab 500mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Lupiximab 500mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
SAFE IF PRESCRIBED
Lupiximab 500mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Lupiximab 500mg Injection may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Lupiximab 500mg Injection in patients with liver disease. Please consult your doctor.
Use of Lupiximab 500mg Injection is not recommended in patients with the active liver disease or those who had viral hepatitis as it can reactivate the infection.

What if you forget to take Lupiximab Injection?

If you miss a dose of Lupiximab 500mg Injection, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • It is given as a drip (intravenous infusion) by your doctor or nurse.
  • You may be given some painkillers, antihistamine and possibly steroids before the drip to help prevent infusion reaction.
  • Your doctor may get blood tests done to check for hepatitis B before treatment and to monitor your blood cells during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
  • Inform your doctor  if you have any heart rhythm problems, if you are having surgery or if you plan to get any vaccinations.

Fact Box

Chemical Class
Monoclonal antibody (mAb)
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
CD 20 Inhibitor

Patient Concerns

arrow
Non Hodgkin lymphoma of defuss large b cells
Dr. Vijay Sharnangat
Medical Oncology and Hematology
I am very much experienced in treating DLBCL
Symptoms of lymphoma And blood cancer
Dr. Vijay Sharnangat
Medical Oncology and Hematology
Symptoms could be like fever, weight loss, anorexia, lymphadenopathy.
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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1745-48.
  2. Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 978.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1225-27.
  4. Rituximab. Garden City, Hertfordshire: Roche Products Limited; 1998 [revised 18 Dec. 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Rituximab. [Updated 2020 Jan 20]. [Accessed 18 Feb. 2020] (online) Available from:External Link

Manufacturer/Marketer Address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Expires on or after: September, 2021

A licensed vendor partner from your nearest location will deliver Lupiximab 500mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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1 Injection in 1 vial
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