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Ltem 500mg Injection

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Ltem 500mg Injection is an anti-epileptic medicine used to treat seizures (fits) in epilepsy. It can be used alone or along with other medicines. It helps to prevent seizures for as long as you continue to take it.
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Levepsy 500mg Injection
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Ltem 500mg Injection
Ltem 500mg Injection
vial of 5 ml Injection
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₹112.5
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Levepsy 500mg Injection
Levepsy 500mg Injection
vial of 5 ml Injection
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₹90.1
₹18.02 per ml

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General Information

The content is shown in English
Ltem 500mg Injection image
Ltem 500mg Injection image

Product introduction

Ltem 500mg Injection is given as an infusion (slow drip) into a vein under the supervision of a healthcare professional. It is generally used for short-term control of seizures when treatment with oral medication is not feasible (eg. when the patient is unconscious). You should continue taking it for as long as your doctor has told you to, even if you feel well. If you stop or miss doses your seizures could get worse. Your doctor is likely to prescribe you oral medicines for long-term seizure control, after treatment with this injection has been completed.

Some common side effects of this medicine include dizziness, headache, infection, irritation, nasopharyngitis, sleepiness, aggressive behavior, and decreased appetite. You may also experience behavioral changes, aggressive behavior, irritation, agitation, etc. Side effects are more common during the first few days and usually lessen as your body gets used to the medicine. Most of these side effects do not need medical attention, but some of them can be serious. Let your doctor know right away if you have developed an allergic reaction (hives, itching, weakness, dizziness, difficulty in breathing, or swelling of face, tongue, and throat), a skin rash, or persistent behavioral changes like confusion, forgetfulness, feeling irritable, increased aggression or hostility. There may be ways of preventing or reducing them. A small number of people being treated with this medicine have had thoughts of harming or killing themselves. Contact your doctor if your mood changes for the worse.

Before taking it, you should tell your doctor if you have kidney problems, depression or suicidal thoughts and if you are pregnant or planning to become pregnant. Avoid alcohol while taking this medicine, as it may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness.  Drowsiness and dizziness may affect your ability to drive or operate machinery. Your kidney function may need to be tested periodically while taking this medicine.

Benefits of Ltem Injection

Treatment of Epilepsy/Seizures
Ltem 500mg Injection belongs to a group of medicines called anticonvulsants (or anti-epileptics). It works by slowing down electrical signals in the brain which cause seizures (fits). This medicine can be used to control various types of seizures—myoclonic, partial-onset, and primary generalized tonic-clonic (or grand mal). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. You should continue taking it even if you feel well and are not having any seizures. Missing doses may trigger a seizure. Do not stop using this medicine until your doctor advises you.

Side effects of Ltem Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ltem
  • Sleepiness
  • Dizziness
  • Decreased appetite
  • Fatigue
  • Headache
  • Behavioral changes
  • Irritation
  • Aggressive behavior
  • Agitation
  • Infection
  • Nasopharyngitis (inflammation of the throat and nasal passages)

How to use Ltem Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Ltem Injection works

Ltem 500mg Injection is an antiepileptic medication. It works by attaching to specific sites (SV2A) on the surfaces of nerve cells. This suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.

Quick tips

  • It is given as IV infusion under the supervision of a doctor.
  • Some healthy tips to prevent seizures:
    • Take a healthy diet along with regular exercise.
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/ laptop.
    • Take your medication on time.
  • It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
  • Inform your doctor if you have ever been diagnosed with kidney disease. The dose of your medicine may need to be adjusted.
  • Your doctor has prescribed Ltem 500mg Injection to reduce the frequency of seizures.
  • Ltem 500mg Injection should be taken at the same time every day to maintain consistent levels in your body.
  • Do not stop using Ltem 500mg Injection without talking to your doctor, even if you feel better.
  • It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
  • Avoid consuming alcohol when taking the Ltem 500mg Injection as it may cause excessive drowsiness and calmness.
  • Inform your doctor if you have ever been diagnosed with kidney disease. The dose of your medicine may need to be adjusted.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Ltem 500mg Injection should be taken regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Take a healthy diet along with regular exercise.
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/ laptop.
    • Take your medication on time.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Ltem 500mg Injection
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Ltem 500mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Ltem 500mg Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Monitor the baby for sleepiness and adequate weight gain.
Driving

Driving

UNSAFE
Ltem 500mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Ltem 500mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

SAFE IF PRESCRIBED
Ltem 500mg Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
However, a lower dose may be advised in patients with severe liver disease.

Interaction with drugs

Taking Ltem with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Carbamazepine (Oral Route)

Talk to your doctor if you experience blurred vision, uncontrolled eye movement, lack of muscle control, and drowsiness. Carbamazepine may reduce blood levels of Levetiracetam.
Moderate

Fosphenytoin (Injection Route)

Talk to your doctor if you experience blurred vision, uncontrolled eye movement, lack of muscle control, and drowsiness. Fosphenytoin may reduce blood levels of Levetiracetam.
Moderate

Methotrexate (Injection Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Methotrexate (Oral Route)

Talk to your doctor if you notice any unusual symptoms.
Moderate

Phenytoin (Injection Route)

Talk to your doctor if you experience blurred vision, uncontrolled eye movement, lack of muscle control, and drowsiness. Phenytoin may reduce blood levels of Levetiracetam.

Frequently asked questions

Ltem 500mg Injection is not known to affect fertility in males or females. However, talk to your doctor if you are facing fertility issues during the treatment with this medicine.
Yes, Ltem 500mg Injection can make you feel sleepy. Therefore, during the initial phase of treatment, avoid driving, operating machinery, working at heights, or participating in potentially dangerous activities until you know how this medicine affects you.
Weight gain is an uncommon side effect of Ltem 500mg Injection. However, the response may vary from person to person. To prevent weight gain you should take a healthy balanced diet, avoid snacking, cut down on high-calorie food items, include more vegetables and fruits in your diet, and exercise regularly. If you still have issues with your weight, consult your doctor.
Ltem 500mg Injection may take a few weeks to start working properly since the dose is increased slowly. Your seizures may continue until Ltem 500mg Injection starts working completely.
You should continue to take Ltem 500mg Injection for as long as your doctor advises you to. Do not stop taking it suddenly because this may increase the frequency of seizures which may be difficult to control.
Yes, you may drink alcohol while taking Ltem 500mg Injection. Alcohol itself does not affect the way Ltem 500mg Injection works. However, alcohol can increase the sleepiness or dizziness that occur as side effects of Ltem 500mg Injection in some individuals. Therefore, you should avoid alcohol while taking Ltem 500mg Injection until you know how it affects you.
No, Ltem 500mg Injection is not habit-forming. No physical or psychological dependence has been reported with Ltem 500mg Injection. Consult your doctor if you experience any side effects.
Taking an excess of Ltem 500mg Injection may cause sleepiness, agitation, aggression, a decrease of alertness, inhibition of breathing, and even a state of coma. In case of an overdose, immediate medical care should be provided to the patient in a nearby hospital.

Fact Box

Chemical Class

Alpha amino acid derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Synaptic Vesicle 2A (SV2A) Protein Ligands- Antiepileptic Drugs (AEDs)

References

  1. Stahl SM, editor. Levetiracetam. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 333-36.
  2. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 600.
  3. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 411.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 789.
  5. Levetiracetam [FDA Label]. Albuquerque, New Mexico: Cardinal Health; 2006. [Accessed 25 Mar. 2019] (online) Available from:
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Levetiracetam. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
  7. Levetiracetam [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2021. [Accessed 08 Jul. 2023]. (online) Available from:
  8. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Levetiracetam. [Updated 2022 Nov 30]. [Accessed 08 Jul. 2023]. (online) Available from:
  9. National Health Service. Pregnancy, breastfeeding and fertility while taking levetiracetam. [Last Reviewed: 10 May 2022]. [Accessed 08 Jul. 2023]. (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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Country of origin: India
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