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Levera Injection

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)
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Overview

Introduction

Levera Injection is an anti-epileptic medicine used to treat seizures (fits) in epilepsy. It can be used alone or along with other medicines. It helps to prevent seizures for as long as you continue to take it.

Levera Injection is given as an infusion (slow drip) into a vein under the supervision of a healthcare professional. It is generally used for short-term control of seizures when treatment with oral medication is not feasible (eg. when the patient is unconscious). You should continue taking it for as long as your doctor has told you to, even if you feel well. If you stop or miss doses your seizures could get worse. Your doctor is likely to prescribe you oral medicines for long-term seizure control, after treatment with this injection has been completed.

Some common side effects of this medicine include dizziness, headache, infection, irritation, nasal congestion (stuffy nose), sleepiness, aggressive behavior, and decreased appetite. You may also experience behavioral changes, aggressive behavior, irritation, agitation, etc. Side effects are more common during the first few days and usually lessen as your body gets used to the medicine. Most of these side effects do not need medical attention, but some of them can be serious. Let your doctor know right away if you have developed an allergic reaction (hives, itching, weakness, dizziness, difficulty in breathing, or swelling of face, tongue, and throat), a skin rash, or persistent behavioral changes like confusion, forgetfulness, feeling irritable, increased aggression or hostility. There may be ways of preventing or reducing them. A small number of people being treated with this medicine have had thoughts of harming or killing themselves. Contact your doctor if your mood changes for the worse.

Before taking it, you should tell your doctor if you have kidney problems, depression or suicidal thoughts and if you are pregnant or planning to become pregnant. Avoid alcohol while taking this medicine, as it may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness.  Drowsiness and dizziness may affect your ability to drive or operate machinery. Your kidney function may need to be tested periodically while taking this medicine.

Uses of Levera Injection

Benefits of Levera Injection

In Epilepsy/Seizures

Levera Injection belongs to a group of medicines called anticonvulsants (or anti-epileptics). It works by slowing down electrical signals in the brain which cause seizures (fits). This medicine can be used to control the various types of seizures—myoclonic, partial-onset, and primary generalized tonic-clonic (or grand mal). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.

It is given as a slow infusion under the supervision of a doctor. It is generally used for immediate control of seizures when treatment with oral medication is not possible.

Side effects of Levera Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Levera

  • Sleepiness
  • Dizziness
  • Decreased appetite
  • Fatigue
  • Headache
  • Behavioural changes
  • Irritation
  • Aggressive behavior
  • Agitation
  • Nasal congestion (stuffy nose)
  • Infection

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Sleepiness
    If the medicine is making you drowsy during the day, stop what you are doing and sit or lie down until you feel better. You can also consider taking a nap. Physical exercises such as walking may be helpful. Do not drink alcohol, as it will make you feel more tired. Avoid driving or operating heavy equipment when you are feeling drowsy. This problem usually goes away as your body gets used to the medicine. However, if it does not, ask your doctor if you can take your medicine at bedtime or whether the dose can be reduced.
  • Coping with Dizziness
    This is usually short-lived and should go away within a few days. If this happens, stop what you are doing and sit or lie down until you feel better. Lying still in a dark, quiet room may help reduce the spinning feeling. Sleep with your head slightly raised on two or more pillows. Get up slowly from a lying or sitting position. Get plenty of rest and try to relax as being anxious can make it worse. Try taking this medicine at bedtime to reduce the symptoms. Drinking plenty of water and ginger tea may also help. Avoid alcohol, caffeine and smoking as it will make you feel worse. Avoid driving or using tools or machinery until you feel better.
  • Coping with Decreased appetite
    It is important to eat, even if you do not feel like it. You might try switching to smaller meals and frequent snacks. Try eating healthy and nutritious snacks that are high in calories and protein, such as dried fruit and nuts. It is important to drink even if you cannot eat. But, do not fill your stomach with liquid before eating. Eat when you are most hungry. Exercise such as a short walk may also increase your appetite. Talk to your doctor about possible medication or supplements if your condition does not improve.
  • Coping with Fatigue
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Behavioural changes, Irritation, and Aggressive behavior
    If you feel this medicine is causing mood or behavior changes, speak to your doctor as you may need a change of medicine. There are also some things you can do yourself. Eat well, do relaxation or deep breathing exercises and practice regular exercise that you enjoy, such as walking, swimming or yoga. Try to avoid caffeine, alcohol and sugar as these can all cause mood swings or make them worse. A good night’s sleep can also help. It often helps to talk to a friend or family member even if you find this difficult. If it bothers you, consult with your doctor.
  • Coping with Agitation
    This often disappears when the condition you are being treated for is managed. You could ask your doctor about changing the dose of your medicine or alternatives if it is affecting your daily life or causing you distress. Psychological treatments may be available. Some things you can do to help yourself include stopping smoking, cutting down the amount of alcohol and caffeine you drink, and doing regular exercise. You should also eat a healthy diet and find out how to get sleep if you are having trouble. Try talking to a friend or family member. Calming breathing exercises and other relaxation techniques may also help.
  • Coping with Nasal congestion (stuffy nose)
    Try saline spray or nose drops. Taking steam inhalation or placing a warm wet towel on your face can also help. Use a humidifier if the air in your house is too dry. Using an extra pillow at night to lift up your head can also improve your breathing. If your condition does not improve, you should talk to your doctor. The doctor may be able to prescribe you certain over-the-counter medicines that can help improve your condition.
  • Coping with Infection
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.

How to use Levera Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Levera Injection works

Levera Injection is an antiepileptic medication. It works by attaching to specific sites (SV2A) on the surfaces of nerve cells. This suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Levera Injection.
Pregnancy
CONSULT YOUR DOCTOR
Levera Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Levera Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the baby for sleepiness and adequate weight gain.
Driving
UNSAFE
Levera Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Levera Injection should be used with caution in patients with kidney disease. Dose adjustment of Levera Injection may be needed. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Levera Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Levera Injection may not be needed in these patients. Please consult your doctor.
However, a lower dose may be advised in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Levera Injection
₹23.91/ml of Injection
₹14.5/ml of Injection
save 39%
Levigress Injection
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Levilex 100mg Injection
MSN Laboratories
₹21.26/ml of Injection
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₹22.92/ml of Injection
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Levipil Injection
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Quick Tips

  • It is given as IV infusion under the supervision of a doctor.
  • Some healthy tips to prevent seizures:
    • Take a healthy diet along with regular exercise.
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/ laptop.
    • Take your medication on time.
  • It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
  • Inform your doctor if you have ever been diagnosed with kidney disease. The dose of your medicine may need to be adjusted.

Fact Box

Chemical Class
Pyrrolidinone & Acetamide Derivative
Habit Forming
No

Patient Concerns

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Epilepsy treatment best medicine
Dr. Vikas Sharma
Neurology
levera is better tolerated
Operated for bi frontal contusions before 5 years now he gets seizures
Dr. Vikas Sharma
Neurology
start tab levera 500 mng bd
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User Feedback


FAQs

Q. Will the use of Levera affect my fertility?

Levera is not known to affect fertility in males or females. However, talk to your doctor if you are facing fertility issues during the treatment with this medicine.

Q. Can the use of Levera cause sleepiness?

Yes, Levera can make you feel sleepy. Therefore, during the initial phase of treatment, avoid driving, operating machinery, working at heights, or participating in potentially dangerous activities, until you know how this medicine affects you.

Q. I have gained weight since I started taking Levera. Is it because of Levera? What should I do?

Weight gain is an uncommon side effect of Levera. However, the response may vary from person to person. To prevent weight gain you should take a healthy balanced diet, avoid snacking, cut down on high-calorie food items, include more vegetables and fruits in your diet and exercise regularly. If you still have issues with your weight, consult your doctor.

Q. How long does Levera take to show its effect?

Levera may take a few weeks to start working properly since the dose is increased slowly. It is possible that your seizures may continue until Levera starts working completely.

Q. For how long do I need to take Levera?

You should continue to take Levera for as long as your doctor advises you to. Do not stop taking it suddenly because this may increase the frequency of seizures which may be difficult to control.

Q. Can I drink alcohol with Levera?

Yes, you may drink alcohol while taking Levera. Alcohol itself does not affect the way Levera works. However, alcohol can increase the sleepiness or dizziness that occur as side effects of Levera in some individuals. Therefore, you should avoid alcohol while taking Levera until you know how it affects you.

Q. Will I get addicted to Levera if I use it for a long time?

No, Levera is not habit-forming. No physical or psychological dependence has been reported with Levera. Consult your doctor if you experience any side effects.

Q. What symptoms can occur if someone takes an excess of Levera?

Taking an excess of Levera may cause sleepiness, agitation, aggression, decrease of alertness, inhibition of breathing and even a state of coma. In case of an overdose, immediate medical care should be provided to the patient in a nearby hospital.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Stahl SM, editor. Levetiracetam. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 333-36.
  2. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 600.
  3. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 411.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 789.
  5. Levetiracetam [FDA Label]. Albuquerque, New Mexico: Cardinal Health; 2006. [Accessed 25 Mar. 2019] (online) Available from:External Link
  6. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Levetiracetam. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  7. Levetiracetam [EMC SmPC]. Hayes, UK: Ranbaxy (UK) Limited a Sun Pharmaceutical Company; 2011 [revised 26 Oct. 2018]. [Accessed 25 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
A licensed vendor partner from your nearest location will deliver Levera Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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5 ml in 1 vial
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