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Lastet 50 Capsule

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 14 Apr 2026 | 04:21 PM (IST)
Lastet 50 Capsule is used to treat different cancers of lung, and testicles. It is also sometimes used to treat some other kinds of cancer in both men and women. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.
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Lastet 50 Capsule
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General Information

Contains

Etoposide (50mg)

Marketer

Khandelwal Laboratories Pvt Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Lastet 50 Capsule image
Lastet 50 Capsule image

Product introduction

Lastet 50 Capsule should be taken on an empty stomach, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you. It can lower your immunity, hence maintain distance from people suffering from cold and any other infection.

The most common side effect of this medicine includes low blood platelets, vomiting, nausea, hair loss, and anemia (low number of red blood cells).  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It is important to use effective contraception to avoid getting pregnant or fathering a child during treatment.

Before taking this medicine, let your doctor know if you have liver or kidney disease, or if have been on radiation therapy. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may check you for blood cells and liver functioning while taking this medicine.

Benefits of Lastet Capsule

Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer commonly caused by smoking that starts with small tumors in the lungs but eventually spreads to the other parts of the body as well. Lastet 50 Capsule helps treat such types of cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
Testicular cancer
Testicular cancer is the cancer in the male organs called testicles, that make male hormones and sperm. The testicles are located inside a loose bag of skin (scrotum) underneath the penis. Lastet 50 Capsule kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells in men. It is given as an injection by a doctor or nurse and should not be self-administered.

Side effects of Lastet Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lastet
  • Anemia (low number of red blood cells)
  • Decreased blood cells (red cells, white cells, and platelets)
  • Decreased white blood cell count
  • Diarrhea
  • Hair loss
  • Liver damage
  • Low blood platelets
  • Nausea
  • Rash
  • Stomatitis (Inflammation of the mouth)
  • Vomiting

How to use Lastet Capsule

Take this medicine in the dose and duration as advised by your doctor. Lastet 50 Capsule is to be taken on an empty stomach.

How Lastet Capsule works

Lastet 50 Capsule is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

All substitutes for Lastet 50 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Lastet 50 Capsule should be taken on an empty stomach.
  • Do not skip any dose and complete the course as suggested by your doctor.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Your doctor may get regular blood tests done to monitor your electrolyte levels, liver function, blood cell count in your blood.
  • Let your doctor know if you notice a skin rash, shortness of breath, difficulty breathing and swelling of the tongue.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Lastet 50 Capsule.
Pregnancy

Pregnancy

UNSAFE
Lastet 50 Capsule is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Lastet 50 Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Lastet 50 Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Lastet 50 Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Lastet 50 Capsule is not recommended in patients with end-stage kidney disease.
Liver

Liver

CAUTION
Lastet 50 Capsule should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Use of Lastet 50 Capsule is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Lastet with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Etoposide.
Severe

Ciclosporin (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Etoposide may raise blood levels of Ciclosporin and its active form.
Severe

Ciclosporin (Injection Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Etoposide may raise blood levels of Ciclosporin and its active form.
Severe

Irinotecan (Injection Route)

Concurrent use should be avoided. Please consult with your doctor.
Moderate

Sodium Valproate (Oral Route)

Do not consume Sodium Valproate with Etoposide. If concurrent use is essential, your doctor may monitor and adjust the doses as per the observations. Etoposide may reduce blood levels and efficacy of Sodium Valproate.

Frequently asked questions

Lastet 50 Capsule is an anti-cancer medicine used to treat certain types of lung cancer, including small cell lung cancer, and testicular cancer. It works by slowing or stopping the growth of cancer cells.
Individuals should not take Lastet 50 Capsule if they are allergic to etoposide or any of its ingredients, if there is any problem in the bone marrow, or have very low blood counts. It should also be avoided in people with severe liver problems unless approved by a doctor.
Yes, Lastet 50 Capsule can lower the number of white blood cells in your body, which weakens your immune system. This makes you more likely to get serious infections. If you develop a fever, sore throat, cough, or any signs of infection, contact your doctor immediately.
Serious side effects of Lastet 50 Capsule may include severe allergic reactions, difficulty breathing, chest pain, mouth ulcers, unusual bleeding, or yellowing of the skin and eyes. These need urgent medical attention.
Yes, in rare cases, long-term use of Lastet 50 Capsule has been linked to the development of secondary cancers, such as leukemia. Your doctor will weigh the benefits against this risk before prescribing it.
Yes, Lastet 50 Capsule may affect fertility in both men and women. It can lower sperm count in men and affect ovarian function in women. Your doctor may discuss fertility preservation options before starting treatment.
Severe diarrhea or painful mouth sores can be serious side effects of Lastet 50 Capsule. You should contact your doctor immediately, as these symptoms may require medical treatment to prevent complications.
Yes, hair loss is a possible side effect of Lastet 50 Capsule. Although it is usually temporary, hair may take some time to grow back after treatment is completed.

Fact Box

Chemical Class

Podophyllotoxins

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Cytotoxic Alkaloids

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1715-16.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 520-21.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Etoposide. [Updated 2019 Jun 3]. [Accessed 18 Feb. 2020] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Khandelwal Laboratories Pvt Ltd
Address: KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA

Vendor Details

Country of origin: India
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