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Testicular cancer
Also known as Germ cell tumourOverview
Testicular cancer happens when abnormal cells grow in the testicles. The testicles are two small glands in the scrotum, located below the penis. They make sperm and male hormones. Common symptoms of testicular cancer include a lump, swelling, or heaviness in the testicle or scrotum.
Testicular cancer accounts for merely 1% of malignancies found in men. It can occur in men of all ages, but is most commonly seen in men aged 15 to 44 years. It usually affects only one testicle. Risk factors for testicular cancer include undescended testicles, family history, and HIV infection.
Testicular cancer is highly treatable, especially when caught early. Based on the diagnosis and stage, your doctor may recommend surveillance, surgery, radiation, chemotherapy, or a combination of these treatments for the best outcome.
Key Facts
- Adults between 15 to 44 years of age
- Men
- Testicles
- Testicular torsion
- Epididymitis
- Hydrocele
- Spermatocele
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Imaging tests: Ultrasound scrotal, CECT scan whole abdomen, Chest X-ray, and CECT scan chest.
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Blood tests: Alpha-fetoprotein (AFP), Beta-human chorionic gonadotropin (beta-hCG), and Lactate dehydrogenase (LDH).
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Surgical removal of the testicle (orchidectomy or orchiectomy)
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Surgery: Radical inguinal orchiectomy and Retroperitoneal lymph node dissection.
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Chemotherapy: Bleomycin, Cisplatin, Etoposide, and Ifosfamide.
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Radiation therapy
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Bone marrow transplantation
- General physician
- General surgeon
- Urologist
- Oncologist
Symptoms of Testicular Cancer
Testicular cancer can cause several symptoms that affect your health. It is possible to experience more than one symptom at the same time. These include:
- Feeling a lump or swelling in either testicle
- Feeling of heaviness in the scrotum
- Collection of fluid in the scrotum
- Experiencing pain or discomfort in one testicle or the scrotum
- Testicular atrophy (shrinking of the testicles)
- Experiencing a dull ache in the abdomen or groin region
- Enlargement or tenderness of the breasts
- Lower back pain
- Swelling of one or both legs or shortness of breath due to a blood clot
- Shortness of breath, chest pain, and blood in sputum or phlegm (when cancer has spread to the lungs)
- Headaches and confusion in case the tumour spreads to the brain.
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Types Of Testicular Cancer
The first step in distinguishing types of testicular cancer often starts with how the tumor cells appear under a microscope. These include:
1. Seminoma
These tend to grow slowly and usually remain confined to the testicles, making them less likely to spread. Seminomas are more common in older adults.
2. Nonseminoma
This type is usually seen at earlier stages of life. Later, it grows in size and spreads rapidly throughout the body. Nonseminoma tumours tend to involve the lymph nodes. There are different types of non-seminoma tumours, like:
- Embryonal carcinoma
- Yolk sac tumour
- Choriocarcinoma
- Teratoma
3. Stromal tumours
Stromal tumors are rare testicular cancers that arise from the supportive tissues around germ cells and usually have a good outcome with surgery. The two main subtypes are:
- Leydig cell tumors
- Sertoli cell tumors.
Causes Of Testicular Cancer
The exact cause of testicular cancer remains unclear. Typically, healthy cells grow and divide in a controlled manner to support normal body function, but in some cases, mutations (changes) cause these cells to grow uncontrollably, even when the body doesn't need them.
The cancerous cells pile up, take up space, and use nutrients meant for healthy cells. Over time, they form a lump that can be felt in the testicle.
Some testicular cancers start in cells that create immature sperm. Researchers have found that many of these cancers have an extra copy of chromosome 12. Others show abnormal numbers or structures of chromosomes.
Certain risk factors increase the probability of testicular cancer, which are discussed in detail in the next segment.
Risk Factors For Testicular Cancer
The following factors are associated with a high risk of testicular cancer.
Non-modifiable factors
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Age group of 15 to 44 years
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Failure of the testicle to descend from the abdomen into the scrotum (cryptorchidism)
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Personal history of testicular cancer
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Family history of testicular cancer
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Race (Incidence is highest in the white race, most rapidly increasing in the Hispanic population, and lowest amongst African-American individuals)
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Abnormal testicular development in conditions like Klinefelter syndrome
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Congenital defects like hypospadias (abnormality of the penis) and inguinal hernia (a lump in the groin)
Modifiable factors
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Infertility or difficulty conceiving a baby
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HPV or HIV infection
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Issues before birth related to the mother’s pregnancy, such as abnormal bleeding and estrogen or hormone therapy
Lifestyle factors
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Smoking
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Cannabis use
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Diet (high consumption of dairy products, red meat, etc)
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Exposure to electromagnetic fields
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Occupational exposure to plastics and high temperatures.
Smoking can lead to testicular cancer. Studies suggest that smoking increases the risk of developing testicular cancer, particularly non-seminomatous tumors. So what are you waiting for? Quit smoking today to reduce your risk.
Home care For Testicular Cancer
It generally takes about two weeks or two months to recover from an orchiectomy that allows doctors to remove the affected testicle. It is important to follow the post-op instructions given by your doctor during your recovery time.
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You will be advised to avoid lifting anything over ten pounds for the first few weeks of the surgery.
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You will also be asked to refrain from engaging in any kind of sexual activity until you have recovered.
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Activities such as exercising, running, or playing sports should be avoided for nearly four weeks post-surgery.
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You will be asked to maintain a schedule of follow-up appointments to minimise the risk of testicular cancer returning.
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You will be asked to learn how to perform self-testicular examinations.
Diagnosis Of Testicular Cancer
Diagnosis of testicular cancer begins with evaluating symptoms and identifying any unusual changes through a medical assessment. It consists of:
1. Clinical examination
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The doctor will examine both testicles to check for lumps or changes
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Other areas like the abdomen, neck, chest, armpits, and groin are checked for swollen lymph nodes
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Breasts and nipples are examined for any unusual growth
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Legs are checked for swelling that could be due to blood clots.
2. Imaging tests
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Ultrasound scrotal: A testicular ultrasound uses sound waves to create an image of the scrotum and testicles. It helps determine the size, nature, and location of the lump.
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CECT scan whole abdomen: It is usually done to evaluate the abdominal area. The presence, size, and location of a tumour, along with associated lymph nodes, can be evaluated.
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Chest X-ray: It is used to ascertain any metastasis (spread) to the lungs.
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CECT chest: It should be performed in case of metastasis to the lung or if lung nodules are identified on chest x-ray.
3. Blood tests
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Alpha-fetoprotein (AFP): It is a protein that may be found in higher levels in the blood if certain types of testicular cancer are present.
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Beta-human chorionic gonadotropin (beta-hCG): It is a hormone that may be elevated in the blood with some types of testicular cancer, helping in diagnosis and monitoring.
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Lactate dehydrogenase (LDH): It is an enzyme that may rise in testicular cancer, indicating tumor burden and helping track disease progression.
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4. Surgical removal of the testicle (orchidectomy or orchiectomy)
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In testicular cancer, the affected testicle is usually removed through surgery and then examined in a lab.
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This procedure helps confirm the diagnosis, and typically, only one testicle is removed since both are rarely affected at the same time.
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Unlike other cancers, a biopsy isn't done directly from the testicle because it may increase the risk of cancer spreading to nearby lymph nodes.
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Prevention Of Testicular Cancer
There’s no known way to prevent testicular cancer yet. Healthy lifestyle habits like eating a balanced diet, staying active, avoiding tobacco, and limiting alcohol may help lower your risk of developing cancer.
But catching it early can stop it from spreading and improve outcomes. Doing a testicular self-exam (TSE) can help spot changes early. Learn more:
Testicular self-exam (TSE)
Start in your teens and do it once a month, ideally after a warm bath or shower when the scrotal skin is relaxed.
How to perform?
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Stand upright during the exam
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Look for any swelling in the scrotum
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Gently feel the scrotal sac to locate each testicle
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Check one testicle at a time by gently rolling it between your thumb and fingers to feel for lumps or changes.
Not sure how to do a testicular self-exam? Don’t worry, our expert’s got you covered.
Specialist To Visit
Testicular cancer requires a comprehensive approach for the best outcomes. Experts who may be involved include:
- General physician
- Urologist
- Oncologist
- Radiation oncologist
- Fertility specialist
A general physician identifies early symptoms and refers you to a specialist for further evaluation.
A urologist diagnoses and performs surgery to remove the affected testicle.
An oncologist plans and manages chemotherapy or targeted cancer treatments.
A radiation oncologist delivers radiation therapy to shrink or destroy cancer cells.
A fertility specialist offers options to preserve fertility before treatment begins.
If you notice a lump, swelling, or any unusual change in the size of your testicle, it’s important to get professional help without delay.
Treatment Of Testicular Cancer
Testicular cancer can be treated based on the type and staging of the cancer. The staging of testicular cancer is based upon understanding the pattern of spread. One staging classification that is used is the TNM system:
- Stage I: Tumour (T) is limited to the testis
- Stage II: Tumour has spread to the lymph nodes (N) in the back of the abdomen (retroperitoneum)
- Stage III: Metastasis (M) of the cancer has spread to other parts of the body, such as the lungs, liver, brain, and bone.
Note: For testicular cancer, an S is also added to the TNM system. Serum tumour marker (S) indicates any elevation of serum tumour markers like AFP, beta-hCG, and LDH.
Management consists of:
1. Surgery
- Radical inguinal orchiectomy: The surgeon makes a small cut in the groin to remove the affected testicle. In early stages, this surgery alone may be enough to treat the cancer.
- Retroperitoneal lymph node dissection: This surgery removes lymph nodes through a cut in the abdomen.
2. Chemotherapy
Chemotherapy treatment is a treatment modality that uses strong medicines that are effective in killing cancer cells. Commonly used chemotherapeutic agents in the treatment of testicular cancer are:
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3. Radiation therapy
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Radiation therapy is a treatment modality that uses high-powered energy beams that work as an effective treatment to kill cancer cells.
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Radiation therapy is often recommended for patients who have the seminoma type of testicular cancer and can also be recommended after surgery to remove a testicle.
4. Bone marrow transplantation
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In this procedure, the bone marrow is taken from the patient and treated with drugs to do away with the cancer cells. The marrow is then frozen.
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The patient is given high-dose chemotherapy with or without radiation therapy to destroy the remaining marrow.
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The marrow earlier removed from the patient is thawed or warmed and injected into a vein of the patient to replace the marrow that was destroyed.
Curcumin, found in turmeric, may help fight testicular cancer by reducing inflammation and slowing the growth of cancer cells. It is important to note that it should not replace the conventional treatment.
Complications Of Testicular Cancer
Testicular cancer can lead to certain complications such as:
1. Excessive female hormones: Some types of testicular cancer make extra hormones like hCG or estrogen. This can cause men to develop enlarged breast tissue, a condition called gynecomastia.
2. Metastasis (cancer spread): If testicular cancer is not treated, it can spread to other body parts. This may cause symptoms like back pain, swollen lymph nodes, or breathing problems if the lungs are involved.
3. Long-term chemotherapy effects: Certain chemo medicines can increase the risk of heart problems, hypertension (high blood pressure), and cholesterol. In rare cases, another type of cancer, like leukemia, can appear years after treatment.
Alternative Therapies For Testicular Cancer
Testicular cancer needs standard medical treatment, but some alternative therapies can ease side effects. These include:
1. Acupuncture
Acupuncture has proven to be a successful alternative therapy for individuals with testicular pain. It involves the insertion of needles through the skin at specific points on the body. Acupuncture can also provide relief for people who have epididymitis (inflammation of the epididymis present at the back of the testicle).
2. Aromatherapy
Aromatherapy uses a mix of essential oils for massages that can make a person feel relaxed. Often, people feel that alternative therapies such as aromatherapy help them cope with the treatment of cancer and allow them to feel relaxed.
Living With Testicular Cancer
Living with testicular cancer can be overwhelming, both physically and emotionally. But with timely diagnosis and the right support, it’s possible to maintain a good quality of life. Tips that could help include:
1. Learn about testicular cancer
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Learning about testicular cancer can help you make comfortable decisions regarding your treatment choice
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It is better to empower yourself with the knowledge of what’s about to happen than to fear the unknown
2. Take care of yourself
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Eat a healthy, well-balanced diet
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Increase the number of fruits and vegetables you intake and get plenty of rest every night
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Try to practice meditation and eliminate sources of stress from your life before the treatment.
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Talk to your doctor about strategies that can help your body prepare for the treatment
3. Prioritize mental and emotional well-being
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Talk openly about your diagnosis and feelings
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Lean on close friends and family for support
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Gather information to understand your treatment better
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Acknowledge physical changes and limitations
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Communicate with your partner about intimacy
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Addressing practical issues like finances, work, etc.
4. Manage the cost of cancer care
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Cancer treatment can be costly and sometimes overwhelming
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Besides medical bills, unexpected expenses may arise
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Financial stress can interrupt treatment if not addressed early
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Reach out to a hospital social worker—they can guide you on grants, insurance claims, and available aid.
Tips for Caregivers
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Offer emotional support and encouragement
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Learn about the treatment plan
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Help manage symptoms and side effects
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Keep track of doctor visits and medications
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Support with hygiene and daily tasks
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Speak with empathy and maintain a positive outlook
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Pitch in with chores and daily routines
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Assist with insurance and financial paperwork.
No one should face cancer alone. At Tata 1mg, we’re here to walk with you, offering trusted care, expert support, and the resources you need at every step of the journey.
Frequently Asked Questions
References
- Testicular self-examination (TSE). Urology Care Foundation. Accessed Dec. 12, 2016.
- Gaddam SJ, Bicer F, Chesnut GT. Testicular Cancer. [Updated 2023 May 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from:
- Testicular Cancer. National Cancer Institute. Available from:
- Cancer Council Australia. Testicular Cancer. Cancer Council Australia, Available from:
- American Academy of Family Physicians. Common anorectal conditions: Part II. Lesions. Am Fam Physician [Internet]. 2018 Feb 15 [cited 2025 Mar 21];97(4):261-8. Available from:
- Hanna N, Timmerman R, Foster RS, et al. Clinical Presentation. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from:
- Johns Hopkins Medicine. Types of Testicular Cancer [Internet]. Baltimore (MD): Johns Hopkins Medicine; [cited 2025 Apr 17]. Available from
- Rosenberg C, Van Gurp RJ, Geelen E, Oosterhuis JW, Looijenga LH. Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas. Oncogene. 2000 Nov 30;19(51):5858-62. Available from:
- Yazici S, Del Biondo D, Napodano G, Grillo M, Calace FP, Prezioso D, Crocetto F, Barone B. Risk Factors for Testicular Cancer: Environment, Genes and Infections-Is It All? Medicina (Kaunas). 2023 Apr 7;59(4):724. Available from
- Rezaei M, Shahbazi R, Hashemi M, et al. Ameliorating Effects of Curcumin on Testicular Cancer. Evid Based Complement Alternat Med. 2023;2023:4558299. Available from
- Wang J, Han L, Bao B, Yu X, Zhang K, Dai H, Li X, Wang B, Li H. The safety and efficacy of acupuncture for epididymitis protocol for a systematic review. Medicine (Baltimore). 2019 Jan;98(1):e13934. Available from:
- Sartorius CA, Hess-Wilson JK. Steroid hormone receptors and prostate cancer: mechanisms of androgen and estrogen receptor cross-talk. Mol Cell Endocrinol. 2007;281(1-2):1-12. Available from: