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Grastim Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 14 Apr 2026 | 04:20 PM (IST)
Grastim Injection is used to prevent infections after chemotherapy. It is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.
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General Information

Contains

Filgrastim (300mcg)

Marketer

Dr Reddy's Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Grastim Injection image
Grastim Injection image

Product introduction

Grastim Injection is given as an injection by a qualified medical professional. You should continue to take as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. You might be asked to get regular tests done to check the number of blood cells in your blood and your bone density level while you are taking this medicine.

The most common side effects of this medicine include bone pain, weakness, headache, and rash. Other than this, pain or redness at the site of injection is common. But, inform your doctor if you notice a lump, swelling, or bruising that does not go away. It might not prevent you from all kinds of infection, hence inform your doctor if you notice fever, chills, rash, sore throat, and swelling around the face or neck.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Grastim Injection

  • Prevention of Infections after chemotherapy

Benefits of Grastim Injection

Prevention of Infections after chemotherapy
Grastim Injection increases the production of white blood cells by stimulating the immune system in our body. White blood cells are those cells that help us to fight infections. This medicine is really effective and must be used under medical supervision. Avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to.

Side effects of Grastim Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Grastim
  • Nausea
  • Increased lactate dehydrogenase level in blood
  • Vomiting
  • Increased uric acid level in blood
  • Oropharyngeal pain
  • Hair loss
  • Fatigue
  • Diarrhea
  • Constipation
  • Decreased appetite
  • Cough
  • Breathing problems
  • Bone pain
  • Weakness
  • Headache
  • Rash
  • Injection site reactions (pain, swelling, redness)

How to use Grastim Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Grastim Injection works

Grastim Injection is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections. .

Quick tips

  • Grastim Injection reduces the risk of infection in people treated with chemotherapy.
  • It is usually given as a daily injection into the tissue just under the skin or into the vein. 
  • You will normally receive your first dose at least 24 hours after your chemotherapy or bone marrow transplant.
  • Store it in the refrigerator, protect it from light, and don't shake it.
  • For a more comfortable injection, leave the syringe at room temperature for 30 minutes before using it.
  • Pain or redness in the area of injection is common. Let your doctor know if you notice a lump, swelling, or bruising that doesn't go away.
  • Use caution while driving or doing anything that requires concentration as Grastim Injection may cause dizziness.
  • Your doctor may get regular tests done to monitor the number of blood cells in your blood, and your bone density level while you are receiving treatment with this medicine.
  • Stop taking Grastim Injection and inform your doctor if you have a fever, shortness of breath, fast rate of breathing or trouble breathing.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Grastim Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Grastim Injection during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Grastim Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Grastim Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Grastim Injection may cause fatigue. This may affect your driving ability.
Kidney

Kidney

SAFE IF PRESCRIBED
Grastim Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

SAFE IF PRESCRIBED
Grastim Injection is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking Grastim with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Methotrexate (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Methotrexate. Please consult with your doctor. Methotrexate may reduce the efficacy of Filgrastim.
Severe

Azathioprine (Oral Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Azathioprine.
Severe

Bendamustine (Injection Route)

Do not consume Filgrastim from 24 hours before and until 24 hours after taking Bendamustine.
Severe

Busulfan (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Busulfan. Please consult with your doctor. Busulfan may reduce the efficacy of Filgrastim.
Severe

Busulfan (Oral Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Busulfan. Please consult with your doctor. Busulfan may reduce the efficacy of Filgrastim.

Frequently asked questions

Grastim Injection is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Grastim Injection works by stimulating the bone marrow (organ in the body where blood cells are produced) to increase the production of specific types of blood cells called neutrophils that help fight infections.
Grastim Injection is used during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells called neutrophils), neutropenia in patients with HIV infection, and before stem cell donation.
No, Grastim Injection does not cause cancer.
The exact cause in unknown, but bone pain is a common side-effect of Grastim Injection.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Granulocyte-Colony Stimulating Factor (G-CSF)

References

  1. Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1074-75.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 545-46.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Filgrastim. [Updated 2019 Jun 3]. [Accessed 18 Feb. 2020] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
  5. Filgrastim-txid. San Diego, CA: Tanvex BioPharma USA, Inc.; 2025.
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User feedback

Infections after chemotherapy
94%
Others
6%
Poor
60%
Excellent
33%
Average
7%
Bone pain
25%
No Side Effect
12%
Anemia (low number of red blood cells)
12%
Headache
12%
Weakness
12%
With food
60%
With or without food
40%
Expensive
87%
Average
13%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.

Vendor Details

Country of origin: India
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