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Epsotal Tablet

Written By Dr. Mayank, Pharm.D
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology
Last updated on 12 Nov 2025 | 12:49 PM (IST)
Epsotal Tablet is a prescription medicine used to treat and prevent epilepsy (seizures). It controls seizures by decreasing the abnormal and excessive activity of the nerve cells in the brain.
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General Information

The content is shown in English
Epsotal Tablet image
Epsotal Tablet image

Product introduction

Epsotal Tablet can be used alone or in combination with other medicines. It should be taken in the dose and duration as advised by your doctor. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine, unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.

The most common side effects of this medicine include skin involuntary eye movement, lack of coordination, slurred speech, mental confusion, nausea, vomiting, constipation, and rash. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.

Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your healthcare team know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Epsotal Tablet can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.

Benefits of Epsotal Tablet

Treatment and prevention of Epilepsy/Seizures
Epsotal Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

Side effects of Epsotal Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Epsotal
  • Slurred speech
  • Confusion
  • Nystagmus (involuntary eye movement)
  • Coordination disorder
  • Sleepiness

How to use Epsotal Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epsotal Tablet may be taken with or without food.

How Epsotal Tablet works

Epsotal Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/laptop.
    • Take your medication on time.
  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • It may increase blood sugar levels. Inform your doctor if you are taking any medicines to treat diabetes.
  • It may cause swollen gum (gum hypertrophy), hence take care of oral or dental hygiene.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Epsotal Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Epsotal Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Epsotal Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Epsotal Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Epsotal Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Epsotal Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Epsotal with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Ticagrelor (Oral Route)

Do not consume Ticagrelor with Phenytoin. Phenytoin may reduce blood levels of Ticagrelor.
Severe

Ranolazine (Oral Route)

Do not consume Ranolazine with Phenytoin. Phenytoin may reduce blood levels and efficacy of Ranolazine.
Severe

Aripiprazole (Oral Route)

If concurrent use is essential, please consult your doctor. They may monitor your treatment and adjust the doses as per the observations. Phenytoin may reduce blood levels of Aripiprazole.
Severe

Lorlatinib (Oral Route)

Do not consume Lorlatinib with Phenytoin. Phenytoin may reduce blood levels of Lorlatinib.
Severe

Acenocoumarol (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

On an average, Epsotal Tablet may stay in your system for 5-6 days. This duration varies from person to person. In some cases, it may stay for about 9-10 days.
Suddenly stopping Epsotal Tablet may cause non-stop seizures (called status epilepticus), which can endanger life. Do not stop taking the medicine without consulting your doctor. If required, your doctor will slowly reduce the dose before stopping it completely.
You should not take Epsotal Tablet if you have liver disease, especially if you have a history of developing a liver problem due to Epsotal Tablet. Also, patients taking Delavirdine (a medicine used in the treatment of HIV infection) should not take Epsotal Tablet. Epsotal Tablet may reduce the effectiveness of Delavirdine on HIV and the virus may also become resistant to Delavirdine. It is advised that you inform your doctor if you have any existing heart disorder before you receive Epsotal Tablet.
Epsotal Tablet can be taken with ibuprofen. No drug-drug interactions have been reported between the two. However, interactions can occur. Please consult your doctor before taking the two medicines together.
The most common side effects related to Epsotal Tablet in children are jerky movements of the eyes (nystagmus) and overgrowth of the gums. In some children, Epsotal Tablet causes problems with thinking or behavior, mood change, slow or clumsy movements, or a loss of energy. Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. These may be avoidable if the dose is increased slowly. These side effects quickly disappear when the dose is reduced.
Epsotal Tablet has not been reported to cause weight gain. However, weight loss can occur with longer term use of a higher dose of Epsotal Tablet. Please consult your doctor if you experience weight gain after taking Epsotal Tablet.
Epsotal Tablet can make you feel sleepy (sedation, somnolence, and drowsiness). Please consult your doctor if you feel very sleepy after taking Epsotal Tablet, especially during the first few weeks of treatment or following a dose increase. Talk to your doctor as you may be advised not to drive or use machines until it is established that your ability to perform such activities is not affected.
Epsotal Tablet does affect birth control. Epsotal Tablet can decrease the effect of oral contraceptives (birth control pills) which can make the contraceptive (birth control) effect unreliable. Please talk to your doctor if you are asked to take the two medicines together as you may need to use extra protection for birth control.

Fact Box

Chemical Class

Hydantoin Derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Sodium Channel Modulators- Antiepileptic drugs (AEDs)

References

  1. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 591-93.
  2. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 403-405.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1111-116.
  4. Phenytoin. Cedex, France: Famar Orleans; 2018. [Accessed 22 Mar. 2019] (online) Available from:
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 22 Mar. 2019] (online) Available from:
  6. Phenytoin. New York, New York: Pfizer; 2009]. [Accessed 22 Mar. 2019] (online) Available from:
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
  8. Phenytoin sodium [FDA Label]. Mumbai, India: Wockhardt Limited; 2007. [Accessed 28 Mar. 2023] (online) Available from:
  9. Phenytoin [Prescribing Information]. New York, NY: Parke Davis; 2025. [Accessed 10 Sep 2025] (online) Available from:
  10. Phenytoin [Prescribing Information]. New York, NY: Pfizer Inc.; 2025. [Accessed 05 Nov 2025] (online). Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biochem Pharmaceutical Industries
Address: BIOCHEM PHARMA, LG 113 / A, Xth Central Mall, Mahavir Nagar, 90ft Road, Next to D Mart, Kandivali - West, Mumbai - 400067.

Vendor Details

Country of origin: India
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