Q. Can I take Dutofeb with rosuvastatin?
Rosuvastatin can be taken with Dutofeb. Rosuvastatin is used to lower bad cholesterol and Dutofeb is used to lower uric acid levels in patients with gout. Many patients of high cholesterol levels also have high uric acid levels. There are no human studies available on this interaction. However, animal research shows that when given together, Dutofeb can increase the blood levels of Rosuvastatin causing a higher risk of its side effects like muscle pain and muscle damage. So, a dose adjustment of Rosuvastatin may be needed when given along with Dutofeb.
Q. Does Dutofeb cause frequent urination?
Dutofeb is not known to cause frequent urination. However, if you experience any such symptom while using the drug, consult your doctor.
Q. How does Dutofeb work for the treatment of gout?
Gout is a type of arthritis in which uric acid levels are very high in the blood and they get deposited in the joints causing swelling, redness and sudden pain in these joints. Dutofeb works by inhibiting the enzyme xanthine oxidase involved in the synthesis of uric acid and hence decreases the level of uric acid in the blood.
No, Dutofeb is not a steroid. It is a xanthine oxidase inhibitor and decreases the serum uric acid levels.
Q. Is Dutofeb useful in lowering the triglyceride levels?
Dutofeb is not indicated for the treatment of hypertriglyceridemia. Conclusive evidence showing the drug lowering triglyceride levels is lacking.
Q. How long does Dutofeb take to work?
After oral intake, the peak plasma concentration of Dutofeb is achieved between 1 to 1.5 hours. However, it may take a few days to weeks to show its effect and you can experience gout attacks during this time. Continue to take your medicine during this time as with continuous use these attacks would decrease.
Q. Is Dutofeb an over the counter product?
Dutofeb is not an over the counter product. It is a prescription medicine and is available as per the doctor's advice.
Q. Is Dutofeb safe to use for a long time?
Studies have shown that Dutofeb is safe for long-term use. However, it should be taken only for the duration as per the doctor's advice.
Q. Can Dutofeb be used for the treatment of heart failure?
Dutofeb is not indicated for the treatment of heart failure. However, high uric acid levels is a risk factor for cardiovascular diseases and the benefit of urate-lowering therapy for cardiac diseases is being explored.
Q. Is Dutofeb useful for treating chronic kidney disease?
Dutofeb is not indicated for the treatment of chronic kidney disease. However, it can be safely used in patients with mild to moderate renal failure for lowering uric acid levels. Safety of the drug in severe renal failure is not established.
Q. Can I use Dutofeb for cancer?
Dutofeb is not used for the treatment of cancer. However, patients with malignant cancer when given anti-cancer drugs, experience a serious condition known as tumor lysis syndrome characterized by increased potassium, phosphate and uric acid levels in the blood due to the killing of cancer cells and this can lead to acute kidney injury, cardiac arrhythmia, and seizures. Dutofeb helps in this condition by lowering the uric acid levels and preventing further complications.
Q. Can I take Dutofeb with allopurinol?
Both Dutofeb and allopurinol are uric acid lowering agents and work in a similar way. So, using both the two medicines together may not be very beneficial and can increase the risk of side effects. However, there have been studies where Dutofeb when used with allopurinol in patients with refractory gout, was quite effective in providing relief. So, a combined use would be best decided by your treating doctor depending on your condition.
Q. Is Dutofeb useful for treating kidney stones?
Dutofeb is not indicated in the treatment of kidney stones. However, some studies show that high renal uric acid excretion may precipitate the formation of calcium stones in the kidney and hence, suggest Dutofeb may have a role in the reduction of stone formation.
Q. Can I take Dutofeb with colchicine?
Dutofeb can be taken with colchicine. In the initial few days of starting Dutofeb, patients may experience an increase in gout attacks because of the movement of uric acid and colchicine and painkillers are given to these patients for the relief of pain and inflammation.
Q. Can I take Dutofeb with azathioprine?
Dutofeb should not be taken with azathioprine. Taking both the medicines together will increase the levels of azathioprine and can cause toxicity.
Q. Can I take Dutofeb with antibiotics?
Dutofeb can generally be taken safely together with antibiotics. However, interactions can occur. Talk to your doctor about the right antibiotic therapy for your condition while you are also taking Dutofeb.
Q. What are the contraindications to the use of Dutofeb?
Use of Dutofeb is contraindicated in patients being treated with azathioprine, mercaptopurine, theophylline, and in patients who develop hypersensitivity to the drug.