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    Information about Febuxostat

    Febuxostat uses

    Febuxostat is used in the treatment of gout.

    How febuxostat works

    Febuxostat is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.

    Common side effects of febuxostat

    Increased liver enzymes, Diarrhea, Headache, Nausea, Skin rash
    Content Details
    Written By
    Dr. Radhika Dua
    MDS, BDS
    Reviewed By
    Dr. Shilpa Garcha
    MD (Pharmacology), MBBS
    Last updated on:
    16 Jan 2020 | 03:50 PM (IST)
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    Available Medicine for Febuxostat

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    Expert advice for Febuxostat

    • Your doctor has prescribed Febuxostat to reduce episodes of gout attack.
    • Take it at the same time every day, with or without food.
    • Take plenty of fluids (2-3 litres) daily while on Febuxostat.
    • Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
    • When you first start taking this medicine, you might have more gout attacks. Do not stop Febuxostat on having an acute attack of gout as that could make an attack worse.
    • Stop taking this medicine and inform your doctor straight away if you have symptoms like rash, itchiness, difficulties in breathing, fever or swelling of limbs or face.

    Frequently asked questions for Febuxostat


    Q. What is Febuxostat used for?

    Febuxostat is used to treat gout in adults. It is mainly used in patients who did not respond to the treatment with allopurinol or who are not able to take allopurinol. Gout is a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints. It causes sudden attacks of redness, swelling, pain and heat in one or more joints.

    Q. What are the side effects of Febuxostat?

    Febuxostat may cause common side effects such as abnormal liver test results, diarrhea, headache, rash, nausea, and even an increase in gout symptoms and localized swelling due to retention of fluids in tissues (edema). Whereas, the serious side effects of Febuxostat include heart problems, gout flares, liver problems, and severe skin and allergic reactions. Immediately inform your doctor if you experience any serious side effects.

    Q. How long should I take Febuxostat?

    The dose and duration of Febuxostat varies from person to person and will be decided by your doctor. It may take several months before Febuxostat begins to prevent gout attacks. Do not stop taking Febuxostat without the advice of your doctor even if you feel better.

    Q. Is Febuxostat better than allopurinol?

    Studies on humans have shown that Febuxostat is more effective than allopurinol in lowering uric acid levels in gout patients.

    Q. What is the best time to take Febuxostat?

    Febuxostat is advised to be taken once a day. It can be taken at any time of the day, but preferably at the same time each day so that you remember to take it every day. This will help maintain the levels of Febuxostat in the body. You can take this medicine with or without food.

    Q. Can Febuxostat cause kidney damage?

    Febuxostat may affect kidneys in different ways, though it is quite uncommon. You may experience blood in the urine, frequent urination, kidney stones, abnormal urine tests (increased level of proteins in the urine) and a reduction in the ability of the kidneys to function properly. Rarely, it may cause changes or decrease in urine amount due to inflammation in the kidneys (tubulointerstitial nephritis). Consult your doctor if your kidney functions get further affected.

    Q. Can I stop taking Febuxostat on my own if I am fine and have no pain or swelling in joints?

    No, do not stop taking Febuxostat without the advice of your doctor even if you feel better. Discontinuation of medicine may increase the levels of uric acid. It may also worsen your symptoms due to the formation of new crystals of urate in and around your joints and kidneys.

    Q. What are the things which I need to know while taking Febuxostat?

    You should be aware that Febuxostat may cause serious heart problems which can be life-threatening in some cases. The symptoms of heart problems include chest pain, shortness of breath or trouble breathing, dizziness, fainting or feeling light-headed, rapid or irregular heartbeat. It may also cause numbness or weakness in one side of your body, slurring of speech and sudden blurry vision, or sudden severe headache. Immediately inform your doctor and seek medical help if you experience any of these symptoms.

    Q. Can Febuxostat cause any liver problems?

    Yes, Febuxostat use may cause liver problems. Your doctor may advise you to get regular blood tests done before and during treatment with Febuxostat to check how well your liver was working before and while taking this medicine. Inform your doctor if you notice symptoms such as fatigue, pain or tenderness on the right side of the abdomen or loss of appetite for several days or longer. It may also cause changes in the color of urine (dark or tea colored) and may make your skin or the white part of your eyes turn yellow (jaundice).

    Content on this page was last updated on 16 January, 2020, by Dr. Varun Gupta (MD Pharmacology)