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Dupox 40mg Injection

Piroxicam (40mg)
Genuine
Authenticity Assured
Prescription
required
Dupox 40mg Injection is a pain-relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 26 Dec 2025 | 05:16 PM (IST)
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2 ml Injection
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General Information

Contains

Piroxicam (40mg)

Marketer

Bennet Pharmaceuticals Limited

Storage

Store below 30°C
The content is shown in English
Dupox 40mg Injection image
Dupox 40mg Injection image

Product introduction

Dupox 40mg Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.

The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), vomiting, stomach pain, indigestion, diarrhea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

This medicine is not recommended for pregnant or breastfeeding women. Pregnant and breastfeeding mothers must consult with their doctors before using the medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

Uses of Dupox Injection

Benefits of Dupox Injection

Pain relief
Dupox 40mg Injection is used for short-term relief of pain, inflammation, and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis or even after a dental (tooth-related) surgery.
Take it as it is prescribed to get the most benefit. Do not take more or for longer than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Dupox Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Dupox
  • Injection site reactions (pain, swelling, redness)
  • Vomiting
  • Stomach pain
  • Nausea
  • Headache
  • Dizziness

How to use Dupox Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Dupox Injection works

Dupox 40mg Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

All substitutes for Dupox 40mg Injection

For information purposes only. Consult a doctor before taking any medicine.

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Zoxycam 40mg Injection

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Xopi 40mg Injection

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Quick tips

  • Dupox 40mg Injection helps relieve pain and swelling of various joints and muscles.
  • It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness. 
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Dupox 40mg Injection.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Dupox 40mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Dupox 40mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Dupox 40mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Dupox 40mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Dupox 40mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Dupox with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Tacrolimus (Oral Route)

If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. They may adjust the doses as per the observations.
Severe

Acenocoumarol (Oral Route)

Do not consume Acenocoumarol with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Phenindione (Oral Route)

Do not consume Phenindione with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe

Methotrexate (Injection Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.
Severe

Warfarin (Oral Route)

Do not consume Warfarin with Piroxicam. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Both Dupox 40mg Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Dupox 40mg Injection.
Both Dupox 40mg Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Dupox 40mg Injection.
Both Dupox 40mg Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Dupox 40mg Injection.
Both Dupox 40mg Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Dupox 40mg Injection. Ketoprofen gel also showed excellent tolerability.
Dupox 40mg Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Both Dupox 40mg Injection and nimesulide are pain killers. However, Dupox 40mg Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Dupox 40mg Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Dupox 40mg Injection.
No. Dupox 40mg Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
No. Dupox 40mg Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
Yes. Methocarbamol can be used with Dupox 40mg Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Paracetamol can be used with Dupox 40mg Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
Yes. Dupox 40mg Injection is a non-steroidal anti-inflammatory drug (NSAID).
Dupox 40mg Injection is a sulphur containing compound. Dupox 40mg Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
No. Dupox 40mg Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
No. Dupox 40mg Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
No. Dupox 40mg Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
No. Dupox 40mg Injection is not a medication to control hypertension. It is important to note that Dupox 40mg Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Dupox 40mg Injection.
No. Dupox 40mg Injection should not be combined with Losartan. It is important to note that Dupox 40mg Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dupox 40mg Injection.
No. Dupox 40mg Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Dupox 40mg Injection.
Yes. Dupox 40mg Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Yes, Dupox 40mg Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Yes. Dupox 40mg Injection can be combined with beta-cyclodextrin. Research has shown that combining Dupox 40mg Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
Yes. There are alternatives to Dupox 40mg Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
No. Dupox 40mg Injection is not a drug to treat allergy. It is a pain killer.
Dupox 40mg Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
No. Dupox 40mg Injection is not known to cause high. It is a non-narcotic painkiller.
Dupox 40mg Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Dupox 40mg Injection is not approved for the treatment of migraine. Research studies have shown that Dupox 40mg Injection is effective in significantly decreasing the pain associated with migraine without aura.
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Dupox 40mg Injection as the cause of back pain can be different for different person.
Yes. Dupox 40mg Injection can be given for the treatment of acute gout. Research studies have shown Dupox 40mg Injection to be highly effective in the treatment of acute gout.
Dupox 40mg Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Dupox 40mg Injection so taking piroxicam can lead to increased risk of renal failure by many folds.
No. Dupox 40mg Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Yes. Dupox 40mg Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
No. Dupox 40mg Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
No. Dupox 40mg Injection is contraindicated in cases of active peptic ulcer disease. Dupox 40mg Injection is known to cause gastric ulceration and bleeding.
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Yes. Dupox 40mg Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
No. Dupox 40mg Injection should not be used with diuretics. Dupox 40mg Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
No. Dupox 40mg Injection should not be used with lithium. Dupox 40mg Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
No. Dupox 40mg Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Fact Box

Chemical Class

Benzothiazines

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

Non-Selective COX 1 & 2 Inhibitors (Enolic Acid Derivatives)

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. Pubchem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:
  8. Piroxicam [Drug Label]. Metro Manila, Philippines: Pfizer, Inc.; 2022. [Accessed 06 Apr. 2024] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Bennet Pharmaceuticals Limited
Address: 6th Floor, “B” Wing, Manubhai Towers,Sayajigunj, Vadodara - 390005 Gujarat. India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Dupox 40mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?
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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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