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Phenindione is used for preventing and dissolving blood clots present in the arteries and veins of legs, lungs, brain or heart.

How it works

Phenindione belongs to a class of medication called anticoagulants. It interferes with the formation of factors II, VII, IX and X involved in blood clotting and thus prevents the formation of clot.

Common side effects

Numbness, Bluish colour in toes, Bruise, Dark colored urine, Diarrhoea, Dizziness, Headache, Loss of consciousness, Black and bloody stools, Nausea, Slurred speech, Urine discolouration, Bleeding from cut, Wound bleeding


Expert advice

  • Inform your doctor if you are an elderly, have lost/gained weight, short term illnesses, history of liver/kidney problems, diarrhea, low levels of iron.
  • Inform your doctor if you are undergoing diet changes (changes in intake of Vitamin K fats, oils), or have low level of protein (type S or K); if you have history of stroke or cardiovascular disease, heart disease, major injury, ulcers or bleeding in stomach or intestines, thyroid disorder, cancer, or are going to have surgery.
  • Tell your doctor if you are taking heart medication, medication for dissolving clots or other anticoagulants.
  • You should be regularly monitored with blood tests while on phenindione therapy.
  • Avoid green leafy vegetables and any other food supplements while you are on therapy with phenindione.
  • Seek immediate medical attention if you experience: unusual bleeding or bruising more easily, getting more infections, feeling weak or tired more than usual, jaundice, problems with your kidneys or liver and hair loss.
  • Phenindione is not recommended in children.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)