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Doloxicam Injection

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Introduction

Doloxicam Injection is a pain relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable.

Doloxicam Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.

The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), vomiting, stomach pain, indigestion, diarrhea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

This medicine is not recommended for pregnant or breastfeeding women. It is very important that pregnant and breastfeeding mothers consult with their doctors before using the medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components, if you are taking this medicine for long-term treatment.

Uses of Doloxicam Injection

Benefits of Doloxicam Injection

In Pain relief

Doloxicam Injection helps to relieve pain, inflammation and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis, and osteoarthritis.
It is given as an injection by a doctor or nurse and should not be self-administered. The dose and duration will be decided by the doctor depending on the condition you are being treated for. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Doloxicam Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Doloxicam

  • Vomiting
  • Stomach pain
  • Nausea
  • Indigestion
  • Diarrhea
  • Injection site reactions (pain, swelling, redness)

How to use Doloxicam Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Doloxicam Injection works

Doloxicam Injection is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).

Safety Advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Doloxicam Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Doloxicam Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Doloxicam Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Doloxicam Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Doloxicam Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Doloxicam Injection may be needed. Please consult your doctor.
No dose adjustment is recommended in patients with mild to moderate kidney disease. Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Doloxicam Injection should be used with caution in patients with liver disease. Dose adjustment of Doloxicam Injection may be needed. Please consult your doctor.

What if you forget to take Doloxicam Injection?

If you miss a dose of Doloxicam Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Doloxicam Injection
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Quick Tips

  • Doloxicam Injection helps relieve pain and swelling of various joints and muscles.
  • It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking this medicine as it may cause excessive drowsiness. 
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Fact Box

Chemical Class
Enolic acid Derivatives
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS

Interaction with Drugs

Taking Doloxicam with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Nimsun, Abinim, Nimulis
LIFE-THREATENING
Brand(s): Oxy Triactin, Sioril
LIFE-THREATENING
Brand(s): Pyregin, Alpagin, Novalgin RC
LIFE-THREATENING

Patient Concerns

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I have frozen shoulder after stroke. What to do
Vipul Aggarwal
Intra articluar injection can be given for pain relief
I am suffering from tennis elbow for last 2 months please give guidance about it.Its on my left hand knee.Doctor suggest me to take completely ten days and give me some medicines and tube.He says me it's a very long time treatment.please give guidance how to kill tennis elbow complentely
Vipul Aggarwal
Dont do anythin that causes painStart with eccenteric loading exercisesIf no relief within 3 weeks consider an injection
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FAQs

Q. What is the difference between Doloxicam Injection and diclofenac?

Both Doloxicam Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Doloxicam Injection.

Q. What is the difference between Doloxicam Injection and naproxen?

Both Doloxicam Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Doloxicam Injection.

Q. What is the difference between Doloxicam Injection and meloxicam?

Both Doloxicam Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Doloxicam Injection.

Q. What is the difference between Doloxicam Injection and ketoprofen?

Both Doloxicam Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Doloxicam Injection. Ketoprofen gel also showed excellent tolerability.

Q. What is the difference between Doloxicam Injection and tramadol?

Doloxicam Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.

Q. What is the difference between Doloxicam Injection and nimesulide?

Both Doloxicam Injection and nimesulide are pain killers. However, Doloxicam Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Q. Can Doloxicam Injection be used in the treatment of chikungunya?

Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Doloxicam Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Doloxicam Injection.

Q. Are Doloxicam Injection and aspirin same?

No. Doloxicam Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Q. Can Doloxicam Injection be used along with dexamethasone?

No. Doloxicam Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.

Q. Can Doloxicam Injection be used with methocarbamol?

Yes. Methocarbamol can be used with Doloxicam Injection as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Can Doloxicam Injection be used along with paracetamol?

Yes. Paracetamol can be used with Doloxicam Injection as no serious side effects are known. Inform your doctor before starting any of the medication.

Q. Is Doloxicam Injection a NSAID?

Yes. Doloxicam Injection is a non-steroidal anti-inflammatory drug (NSAID).

Q. Is Doloxicam Injection a sulfa drug?

Doloxicam Injection is a sulphur containing compound. Doloxicam Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Q. Is Doloxicam Injection a blood thinner?

No. Doloxicam Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

Q. Is Doloxicam Injection a muscle relaxant?

No. Doloxicam Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Q. Is Doloxicam Injection a narcotic?

No. Doloxicam Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Q. Can Doloxicam Injection be used in hypertension?

No. Doloxicam Injection is not a medication to control hypertension. It is important to note that Doloxicam Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam Injection.

Q. Can Doloxicam Injection be used along with Losartan?

No. Doloxicam Injection should not be combined with Losartan. It is important to note that Doloxicam Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam Injection.

Q. Can Doloxicam Injection be used with Lisinopril?

No. Doloxicam Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam Injection.

Q. Can Doloxicam Injection be used with calcium channel blocker?

Yes. Doloxicam Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Q. Can Doloxicam Injection be used with Tizanidine?

Yes, Doloxicam Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Q. Why is beta cyclodextrin added to Doloxicam Injection?

Yes. Doloxicam Injection can be combined with beta-cyclodextrin. Research has shown that combining Doloxicam Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Q. Are there any alternatives of Doloxicam Injection?

Yes. There are alternatives to Doloxicam Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Q. What are the contraindications for Doloxicam Injection?

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Q. Can Doloxicam Injection be used in the treatment of allergy?

No. Doloxicam Injection is not a drug to treat allergy. It is a pain killer.

Q. How long does Doloxicam Injection work?

Doloxicam Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Q. Can you get high by using Doloxicam Injection?

No. Doloxicam Injection is not known to cause high. It is a non-narcotic painkiller.

Q. Can Doloxicam Injection be used to treat menstrual cramp?

Doloxicam Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Q. Can I use Doloxicam Injection for a migraine?

Doloxicam Injection is not approved for the treatment of migraine. Research studies have shown that Doloxicam Injection is effective in significantly decreasing the pain associated with migraine without aura.

Q. Is Doloxicam Injection effective in back pain management?

Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Doloxicam Injection as the cause of back pain can be different for different person.

Q. Is Doloxicam Injection affective in gout management?

Yes. Doloxicam Injection can be given for the treatment of acute gout. Research studies have shown Doloxicam Injection to be highly effective in the treatment of acute gout.

Q. Can you donate blood when on the medication with Doloxicam Injection?

Yes. You can donate blood when on Doloxicam Injection. Do inform your doctor before donating blood.

Q. Can I use Doloxicam Injection if I am a diabetic?

Doloxicam Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Doloxicam Injection so taking piroxicam can lead to increased risk of renal failure by many folds.

Q. Can I use Doloxicam Injection if I have a deranged renal function?

No. Doloxicam Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Q. Can Doloxicam Injection lead to skin reactions?

Yes. Doloxicam Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Q. Can I use Doloxicam Injection if I am pregnant?

No. Doloxicam Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

Q. Can I use Doloxicam Injection if I have peptic ulcer disease?

No. Doloxicam Injection is contraindicated in cases of active peptic ulcer disease. Doloxicam Injection is known to cause gastric ulceration and bleeding.

Q. Can I use Doloxicam Injection if I have asthma?

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Q. Can Doloxicam Injection lead to difficulty in conception?

Yes. Doloxicam Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Q. Can Doloxicam Injection be used with diuretics?

No. Doloxicam Injection should not be used with diuretics. Doloxicam Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Q. Can Doloxicam Injection be used with lithium?

No. Doloxicam Injection should not be used with lithium. Doloxicam Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Q. Can Doloxicam Injection be used with warfarin?

No. Doloxicam Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Q. What increases the chances of getting a gastric ulcer when I am already taking Doloxicam Injection?

The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Doloxicam Injection?

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Q. What are the serious side effects of Doloxicam Injection?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 628.
  2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 989-90.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1127-28.
  4. Pubchem. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  5. ScienceDirect. Piroxicam. [Accessed 02 Apr. 2019] (online) Available from:External Link
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:External Link
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.
Expires on or after: March, 2021

A licensed vendor partner from your nearest location will deliver Doloxicam Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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