A psychotropic drug is a medicine affecting the mind, emotions, and behaviour. Dmentin has a beneficial effect on the behavioural symptoms of patients with moderate to severe Alzheimer's Disease. Therefore it is considered as a psychotropic agent.
No. Dmentin is not a narcotic. It does not have habit forming potential.
No. Mood stabilisers are used to treat mania and bipolar disorder. Dmentin is not approved for these conditions yet, although studies are going on for the role of Dmentin in these diseases also.
No. Dmentin does not fit in the generally accepted "Nootropic" descriptor for healthy people. Nootropics are drugs which increase cognition/ motivation/ creativity in healthy individuals. Dmentin, on the other hand, improves cognition in patients with Alzheimer's Disease.
Q. Is Dmentin a cholinesterase inhibitor?
No. Dmentin does not function by inhibiting the cholinesterase enzyme found in the endings of nerve cells. Rather, it acts by preventing the toxicity of an excitatory substance called glutamate in the brain.
Yes. Dmentin acts as an antagonist at the NMDA receptor. This is the receptor in the brain through which glutamate, an excitatory substance, damages the nerve cells in the brain, which is found in Alzheimer's disease.
Cmax (Peak plasm concentration) of Dmentin is 35-40 ng/ml.
Q. Can I take Dmentin with vitamin D?
It has been reported in some studies that a combination of Dmentin and Vitamin D improves cognition in Alzheimer's Disease. However, more studies are required to confirm this finding.
Q. Can I take Dmentin with vitamin E?
Some studies have reported that among patients with mild to moderate Alzheimer's disease, taking alpha-tocopherol (Vitamin E) with Dmentin slows the progressive functional decline. However, more studies are required to confirm this finding.
Dmentin is started when a person starts suffering from moderate to severe Alzheimer's Disease and has failed other options. Despite years of research for mild Alzheimer's Disease, Dmentin has not been found to be useful in it.
Dmentin is prescribed to improve the cognitive (memory) function in patients with Alzheimer's Disease when other treatment options like cholinesterase enzyme inhibitors have failed.
Q. What is the interaction of Dmentin with metformin?
The interaction between Dmentin and Metformin is minor. Dmentin oral increases the level or effect of metformin by nonacidic drugs competing for the same pathway through the kidney.
Q. What is the interaction of Dmentin with warfarin?
No known interaction between Dmentin and Warfarin has been found.
The role of Dmentin in Lewy Body Dementia (LBD) is controversial. Some studies suggest that it is safe and efficacious in this disease whereas others have shown exacerbation of LBD due to Dmentin. Dmentin is not approved for use in Lewy Body Dementia.
Q. Can Dmentin combined with donepezil?
A combination of Dmentin and Donepezil can be given in moderate to severe Alzheimer's Disease. It has been shown that the combination may have additive effects i.e. effects of both drugs are added when given together in some studies.
Q. Can Dmentin be used with rivastigmine?
Dmentin in combination with rivastigmine is safe and beneficial in patients with Alzheimer's Disease. Patients have improvement or stabilisation on dual therapy.
Dmentin is not indicated for use in chronic pain. It has been proposed as a medication for the treatment of neuropathic pain for its mechanism, safety, lack of serious adverse effects, and the relatively rapid onset of action. However, studies have not been promising so far and its routine use in neuropathic pain is not currently recommended.
Dmentin is not indicated for use in Opioid withdrawal. In a number of small studies, it has been seen that Dmentin decreased the expression of opioid physical dependence in humans but there is a need for more studies in this field.
Dmentin has failed to demonstrate clinical efficacy in autism. Studies are currently in progress for other clinical applications.
Dmentin has failed to demonstrate clinical efficacy in vascular dementia although it was well-tolerated.