Take precautions while taking didanosine as it may cause conditions such as peripheral neuropathy (numbness, tingling and pain in arms and legs), changes in eye, pancreatitis (inflammation of the pancreas), changes in body fat distribution, osteonecrosis (death of bone tissue) and reoccurrence of symptoms from previous infections (Immune Reactivation Syndrome) or opportunistic infections (infections due to weakened immune system).
Seek for immediate medical attention if you develop a condition called as lactic acidosis (increased levels of lactic acid in blood), which can turn fatal if not treated; or if you observe any symptoms such as nausea, vomiting and stomach pain.
Inform your doctor if you are suffering from or have a history of pancreatitis (inflammation of the pancreas), kidney or liver diseases (hepatitis B or C infections)
Tell your doctor if you are or are planning to become pregnant. Didanosine if consumed in combination with stavudine during pregnancy may increase the chance of lactic acidosis.
Patients who are taking didanosine along with ganciclovir, valganciclovir are more prone to side effects and hence require close supervision.