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Depsert 100mg Tablet

Sertraline (100mg)

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Depsert 100mg Tablet is a medicine that is used to treat major depressive disorder (MDD) and obsessive-compulsive disorder (OCD). It works by increasing the levels of serotonin, a natural chemical in the brain that plays an important role in mood, emotions, and behavior.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 03 Nov 2026 | 01:04 AM (IST)

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Sertraline (100mg)

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General Information

Contains

Sertraline (100mg)

Marketer

Reliance Formulation Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Depsert 100mg Tablet should be taken exactly as prescribed by your doctor. It can be taken with or without food, but it is best to take it at the same time each day to help you remember. Treatment for depression and OCD often takes several weeks before you start to feel the full benefit, so it is important to keep taking the medicine regularly and not stop suddenly, even if you feel better.

Stopping the medicine too quickly may cause withdrawal symptoms or make your condition return. For the best results, combine the treatment with healthy habits such as regular sleep, exercise, and support from family, friends, or counseling if recommended.

Some common side effects of Depsert 100mg Tablet include nausea, indigestion, loss of appetite, increased sweating, tremors, insomnia (difficulty in sleeping), and diarrhea. Sexual side effects like decreased sexual drive, delayed ejaculation, and erectile dysfunction may also be seen. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself.

Before taking this medicine, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, heart problems, or glaucoma. These may affect your treatment. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines may affect the way it works, especially other antidepressants and medicines called MAO inhibitors. Inform your doctor about all the medicines you are taking to make sure you are safe.

Uses of Depsert Tablet

Benefits of Depsert Tablet

Treatment of Depression
Depsert 100mg Tablet helps lift the low mood, sadness, and loss of interest that come with depression. It helps improve energy, sleep, and overall mood, allowing people to get back to their routines, enjoy daily activities again, and feel more like themselves. Staying on treatment also lowers the chance of depression coming back, helping patients maintain stability and move forward with their lives.

Treatment of Obsessive-compulsive disorder
For people with OCD, Depsert 100mg Tablet reduces the unwanted thoughts and repetitive behaviors that interfere with daily life. It helps quiet the cycle of obsessions and compulsions, making it easier to focus, relax, and participate in normal activities at home, school, or work. With continued use, it not only improves day-to-day functioning but also helps prevent symptoms from returning, giving patients better long-term control.

Side effects of Depsert Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Depsert

Indigestion
Nausea
Tremors
Diarrhea
Ejaculation disorder
Decreased appetite
Decreased libido
Sweating

How to use Depsert Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depsert 100mg Tablet may be taken with or without food.

How Depsert Tablet works

Depsert 100mg Tablet is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of obsessive-compulsive disorder.

All substitutes for Depsert 100mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Do not drive or do anything requiring concentration until you know how Depsert 100mg Tablet affects you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Inform your doctor if you experience decreased sex drive or difficulty having an orgasm.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Depsert 100mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Depsert 100mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Depsert 100mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Depsert 100mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Depsert 100mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

UNSAFE

Depsert 100mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Depsert with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Sertraline. If Moclobemide is essential, ensure a gap of at least 1 week after discontinuing Sertraline. Please consult your doctor.

Life-threatening

Tapentadol (Nasal Route)

Avoid concurrent use unless your doctor considers it safe.

Life-threatening

Zolmitriptan (Nasal Route)

If concurrent use is essential, watch out for symptoms of serotonin syndrome such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may monitor and adjust the doses as per the observations.

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Sertraline. If Tranylcypromine is essential, ensure a gap of at least 1 week after discontinuing Sertraline. Please consult your doctor.

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Sertraline. If Selegiline is essential, ensure a gap of At least 2 weeks after discontinuing Sertraline. Please consult your doctor.

Frequently asked questions

How long does it take for Depsert 100mg Tablet to work?

You may start noticing an improvement in symptoms within 7 days of taking Depsert 100mg Tablet. However, it may take longer to show a full response and will vary from person to person.

How long do I need to take Depsert 100mg Tablet?

You should continue taking Depsert 100mg Tablet as long as your doctor recommends taking it, which may be for several months. Doctors usually recommend the medicine for 6 months to a year after you no longer feel depressed. It is important to know that stopping the medication before the suggested time may cause depression to come back.

When is the best time to take Depsert 100mg Tablet?

Depsert 100mg Tablet is usually taken once a day and can be taken at any time of the day. It can be taken with or without food. Take it as per your convenience, but preferably at the same time each day. Some people who have sleep difficulty after taking Depsert 100mg Tablet should take it in the morning. Whereas some take it at night to limit the side effects of nausea and vomiting.

Does Depsert 100mg Tablet cause sleepiness?

Yes, Depsert 100mg Tablet may commonly cause sleepiness. In case you feel dizzy, sleepy, or tired after taking Depsert 100mg Tablet, you should avoid driving or using heavy machinery. This generally happens within the first few days and weeks after starting Depsert 100mg Tablet, which may disappear after 2-3 months of use of Depsert 100mg Tablet.

What does Depsert 100mg Tablet do for anxiety?

Depsert 100mg Tablet belongs to the selective serotonin reuptake inhibitor (SSRI) class of medicines. It increases the levels of serotonin, which is an important chemical and a neurotransmitter. This increase in serotonin levels can help to improve and regulate your mood, resulting in an improvement in the symptoms of anxiety.

Can I stop taking Depsert 100mg Tablet if I am better now?

No, you should not stop taking Depsert 100mg Tablet without consulting your doctor. This is because the sudden discontinuation of Depsert 100mg Tablet may cause withdrawal symptoms. Hence, it is important to gradually reduce the dose with time (over several weeks or months).

What are the withdrawal symptoms of Depsert 100mg Tablet?

The withdrawal symptoms of Depsert 100mg Tablet include dizziness, nausea, numbness or tingling in the hands or feet, trouble sleeping, feeling agitated or anxious, headaches, and shaking. However, these symptoms are generally mild to moderate and disappear after 1-2 weeks of discontinuing Depsert 100mg Tablet.

What are the symptoms of an overdose of Depsert 100mg Tablet?

The symptoms of overdose of Depsert 100mg Tablet include nausea, dizziness, fever, vomiting, confusion, shakiness, and a rapid heartbeat. Whereas, serious side effects include fainting, delirium, heart problems, and changes in blood pressure. If you experience such symptoms, immediately contact your doctor or seek emergency medical services in a nearby hospital.

Fact Box

Chemical Class

Tametralines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Selective Seretonin Reuptake Inhibitors (SSRIs)

References

Stahl SM, editor. Sertraline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 625-30.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1253-58.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Singh HK, Saadabadi A. Sertraline. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 06 Aug. 2023] (online) Available from:
Kornstein SG, Pearlstein TB, Fayyad R, Farfel GM, Gillespie JA. Low-dose sertraline in the treatment of moderate-to-severe premenstrual syndrome: efficacy of 3 dosing strategies. J Clin Psychiatry. 2006 Oct;67(10):1624-32. [Accessed 06 Aug. 2023] (online) Available from:
Sertraline [Package Insert]. Gangtok, Sikkim: Torrent Pharmaceuticals Ltd.; 2022. [Accessed 06 Aug. 2023] (online) Available from:
Sertraline Hydrochloride [Prescribing Information]. Morgantown, WV: Viatris Specialty LLC; 2023. [Accessed 06 Aug. 2023] (online) Available from:

User feedback

Patients taking Depsert 100mg Tablet

Once A Day

88%

Twice A Day

12%

What are you using Depsert Tablet for?

Depression

50%

Obsessive-compulsive disorder

50%

How do you take Depsert Tablet?

With food

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Reliance Formulation Pvt Ltd
Address: Reliance Formulation Private Limited, 201-202, Anand Mangal-3, Rajnagar Club Road Ambabadi, Ahmedabad-380015, Gujarat, India

Vendor Details

Country of origin: India

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Neuro Cns

Anti Depressants And Mood Stabilisers

Depsert 100mg Tablet

Depsert 100mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Depsert Tablet

Benefits of Depsert Tablet

Side effects of Depsert Tablet

How to use Depsert Tablet

How Depsert Tablet works

All substitutes for Depsert 100mg Tablet

SErta 100 Tablet

Daxid 100mg Tablet

Zosert 100 Tablet

Serlift 100 Tablet

Sertima 100 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Tapentadol (Nasal Route)

Zolmitriptan (Nasal Route)

Tranylcypromine (Oral Route)

Selegiline (Oral Route)

Frequently asked questions

How long does it take for Depsert 100mg Tablet to work?

How long do I need to take Depsert 100mg Tablet?

When is the best time to take Depsert 100mg Tablet?

Does Depsert 100mg Tablet cause sleepiness?

What does Depsert 100mg Tablet do for anxiety?

Can I stop taking Depsert 100mg Tablet if I am better now?

What are the withdrawal symptoms of Depsert 100mg Tablet?

What are the symptoms of an overdose of Depsert 100mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References