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Composition for DEPAXIL

Paroxetine(12.5 mg)

Drug interaction for DEPAXIL

It can be taken with or without food, but it is better to take it at a fixed time.
It may cause excessive drowsiness and calmness with alcohol.
It is unsafe to use during pregnancy.
Human and animal studies have shown adverse effects on the foetus. The potential benefits may warrant the use in pregnant women despite potential risks. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Paroxetine(12.5 mg)


Depaxil cr 12.5 mg tablet is used in adults in the treatment of depression, obsessive compulsive disorder or OCD (repetitive, obsessive thoughts with uncontrollable behavior), Panic disorder (panic attacks, including those caused by fear of open spaces called agoraphobia), generalized anxiety disorder (general feeling of nervousness or anxiety), Social anxiety (fear of social surroundings), Post-traumatic stress disorder/PTSD (anxiety caused by a traumatic event).

How it works

Depaxil cr 12.5 mg tablet belongs to a group of drugs called as selective- serotonin reuptake inhibitors (SSRIs). It works by increasing the level of the chemical serotonin in the brain, which is  usually decreased in depression and related diseases.

Common side effects

Vomiting, Nausea, Abdominal pain, Memory loss, Altered sexual function, Confusion, Nervousness, Constipation, Dizziness, Diarrhoea, Altered taste, Flatulence, Headache, Heartburn, Impaired concentration, Loss of appetite, Weakness, Weight gain


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Expert advice for DEPAXIL

Take the medicine with food to avoid stomach upset. It is best to take the drug in the morning.
Do not take the medicine If you are allergic to it or to any other content in the medicine.
Inform your doctor before taking the medicine:
  • If you experience increased depression, suicidal behavior, bipolar disorder (mania), restlessness, agitation, overactive behavior, confusion, fits (seizures or epilepsy), serotonin syndrome (muscle cramps, fever, anxiety).
  • If you are pregnant or planning to become pregnant or breast-feeding a baby.
Do not drive or operate heavy machinery while taking paroxetine as it may cause drowsiness and lack of concentration.

Frequently asked questions for DEPAXIL


Q. Is Paroxetine safe in pregnancy?
Paroxetine may cause harm to the fetus. Hence, it is not advisable to take it in pregnancy without consulting your doctor.
Q. Is Paroxetine a narcotic/controlled/addictive substance?
No. Paroxetine is not a narcotic/controlled substance. However, it can cause addiction in some cases because of its effects on the brain.
Q. Is paroxetine available or sold over the counter?
No. Paroxetine is a prescription drug. It is not available or sold over the counter.
Q. Is paroxetine the same as Xanax?
No. Paroxetine is an anti-depressant while Xanax (alprazolam) is a sedative/anti-epileptic drug.
Q. Is paroxetine safe?
Yes. Paroxetine is relatively safe if used as recommended. In case of any side-effects, consult your doctor.
Q. Is paroxetine a MAOI/benzodiazepine/anti-depressant?
Paroxetine is not a MAOI (mono-amino oxidase inhibitor) or a benzodiazepine. It is an anti-depressant.
Q. Can I take paroxetine with ibuprofen/diazepam/Tylenol/Xanax/tramadol/propranolol?
Paroxetine should not be taken with diazepam, Xanax (alprazolam), paracetamol (Tylenol), tramadol or propranolol as it interacts with these drugs. Please consult your doctor before use.
Q. Can I take paroxetine without food?
Taking paroxetine without food may cause urge to vomit (nausea). It is advisable to take the medicine with food or after having food.
Q. Does paroxetine cause headache, weight loss, memory loss, hair loss, high blood pressure?
Yes. Paroxetine may cause headache, weight loss, memory loss, hair loss or high blood pressure. If you experience any such symptoms, please consult your doctor.
Q. Can paroxetine be taken during lactation?
No. Paroxetine should not be taken while breast-feeding a baby.


Content on this page was last updated on 17 September, 2014, by Dr. Varun Gupta (MD Pharmacology)