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18 Feb 2020 | 05:25 PM (IST)
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Defrijet 500 Tablet

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)

Overview

Introduction

Defrijet 500 Tablet is a medicine used in the treatment of chronic iron overload caused by frequent blood transfusion. It helps remove the excess iron from the body and reduce the risk of it causing organ damage.

Defrijet 500 Tablet should be taken in empty stomach. Take it regularly at a fixed time each day to get the maximum benefit of the medicine.

Using of Defrijet 500 Tablet may cause common side effects such as nausea, headache, constipation, diarrhea and increased liver enzyme. If the side effects persist or worsen, inform your doctor.

Side effects of Defrijet Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Defrijet

  • Nausea
  • Headache
  • Vomiting
  • Rash
  • Abdominal pain
  • Constipation
  • Itching
  • Increased liver enzymes
  • Abdominal distension
  • Diarrhea

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Rash
    There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat dry your skin after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse, so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure. Always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.
  • Coping with Abdominal pain
    In most cases, this is mild enough to be treated at home. Try to rest and relax. Putting a heat pad or covered hot water bottle on your stomach may also help. Having a warm bath or shower can help you relax and relieve the pain. Drink plenty of clear fluids such as water and reduce your intake of coffee, tea, lemon juice or soda. Avoid alcohol and smoking as these can aggravate the pain. Eating slowly and having smaller and more frequent meals can also help. If the pain is severe, speak to your doctor. They may be able to guide you better.
  • Coping with Constipation
    Try to eat foods which are high in fiber such as fresh fruits, vegetables and cereals to increase the bulk and consistency of bowel movements. Drink plenty of water or non-alcoholic drinks and stay hydrated to promote healthy digestion. Increasing physical activities such as walking, yoga and regular exercise can also be helpful. If your condition does not improve, you can ask your doctor to prescribe you laxative medicine.
  • Coping with Increased liver enzymes
    There may be no symptoms, so your doctor should carry out a blood test and give you advice. Some lifestyle changes can bring down levels of liver enzymes. In general, you will need to stop drinking alcohol or limit the amount you drink, lose weight and keep active. Drink plenty of fluids to avoid dehydration. Eat a healthy diet. Some particular foods like nuts, fatty fish, coffee, tea, olive oil, sprouts and bananas may be beneficial. Try to control stress as this can make your symptoms worse.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.

How to use Defrijet Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Defrijet 500 Tablet is to be taken empty stomach.

How Defrijet Tablet works

Defrijet 500 Tablet traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Defrijet 500 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Defrijet 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Defrijet 500 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Defrijet 500 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
UNSAFE
Defrijet 500 Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Liver
CAUTION
Defrijet 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Defrijet 500 Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Defrijet 500 Tablet in these patients.

What if you forget to take Defrijet Tablet?

If you miss a dose of Defrijet 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Defrijet 500 Tablet
₹40.27/Tablet
Deferglob 500mg Tablet
Globela Pharma Pvt Ltd
₹42/Tablet
4% costlier
₹50.73/Tablet
26% costlier

Quick Tips

  • Always take deferasirox tablet on an empty stomach by dissolving into a glass of water.
  • Do not chew, crush, break or swallow the tablets as a whole.
  • Deferasirox may cause dizziness. It is advisable not to drive or operate any machinery until you feel normal again.
  • Avoid taking deferasirox if you are pregnant, planning to become pregnant or are breast feeding.

Fact Box

Chemical Class
Triazole & benzoate derivative
Habit Forming
No

Patient Concerns

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Hello doctor I have thallassemia major since birth and due to iron overload of repetitive blood transfusion i have diagnosed with diabetes 3 yr ago -at the time of diabetes diagnosis my sugar level is 650 mg/dl. Now according to my case what could be the state of my diabetes type 1 or type 2 ?
Dr. Amit Modi
Paediatrics
Hello, Diabetes in thalassaemia is thought to be caused mainly by iron overload, from repeated blood transfusions, damaging the pancreas. Insulin secretion may be reduced, possibly because iron is directly toxic to the insulin producing pancreatic ?-cells. So it is type 1 DM .
Diabatic for last 4 years insulin dependent D Vitamin iron deficiency
Dr. Ila Jain Khandelwal
Pathology
Dear Sir Thank you for sharing your reports with me. It shows the following important things: 1. your iron level is low, for this you can have a diet rich in lots of iron like jaggery, spinach, leafy vegetables etc. Your vitamin D level is low, for this you can have calcirol sachet in milk once a week for at least 6 weeks. Your glycosylated hemoglobin and average blood glucose level is high, you should consult your doctor for this for the review of treatment.
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Do you have any questions related to Defrijet 500 Tablet ?

User Feedback


FAQs

Q. What is Defrijet used for?

Defrijet is used for removing excess iron from the body due to repeated blood transfusions in patients with beta thalassemia major (a blood disorder)

Q. How does Defrijet work?

Defrijet works by binding to excess iron in the blood and removing it from the body through stool.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Byrns MC, Penning TM. Environmental Toxicology: Carcinogens and Heavy Metals. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1875-76.
  2. Kosnett MJ. Heavy Metal Intoxication & Chelators. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1010.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 365.
  4. Deferasirox. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2006 [revised 23 Jul. 2018]. [Accessed 6 Apr. 2019] (online) Available from:External Link
  5. Medscaape. Deferasirox. [Accessed 6 Apr. 2019] (online) Available from:External Link
  6. Deferasirox. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 2006 [revised 23 Jul. 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  7. Drugs.com. Deferasirox Pregnancy and Breastfeeding Warnings. [Accessed 6 Apr. 2019] (online) Available from:External Link
  8. Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
MRP
402.65
10 tablets in 1 strip
SOLD OUT

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