Combac 30mg Tablet

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Consern Pharma P Ltd

Composition for Combac 30mg Tablet

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Primarily used for

Potentiallyunsafewith
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Alcohol
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Pregnancy
69.75
₹6.97/Tablet
10 tablets in 1 strip
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Medicine Overview of Combac Tablet

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Uses of Combac Tablet

Combac 30mg Tablet is used in the treatment of Depression, Anxiety disorder, Diabetic nerve disease, Fibromyalgia and neuropathic pain.
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Side effects of Combac Tablet

Common

Nausea, Headache, Dry mouth, Sleepiness, Dizziness.

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How to use Combac Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It can be taken with or without food, but it is better to take Combac 30mg Tablet at a fixed time.

How Combac Tablet works

Combac 30mg tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

In Depth Information on Combac Tablet

Expert advice for Combac Tablet

  • You may have to wait for 2 to 4 weeks to get the full effect.
  • If your doctor asks you to stop Combac, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks.
  • Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate).
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you.
  • It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.
  • Monitor blood pressure (BP) frequently.
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Warnings
Special precautions for Combac 30mg Tablet
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Alcohol
CAUTION
Combac 30mg Tablet may cause excessive drowsiness and calmness with alcohol.
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Pregnancy
WEIGH RISKS VS BENEFITS
Combac 30mg Tablet may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
CAUTION
Combac 30mg Tablet should be used with caution during lactat
ion. Breast feeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
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Driving
Combac 30mg Tablet may make you feel dizzy, sleepy, tired, o
r decrease alertness. If this happens, do not drive.
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Kidney
There is limited information available on the use of Combac 30mg Tablet in patients with kidney disease. Please consult your doctor.

Caution should be used in patients with severe renal impairment.
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Liver
There is no data available. Please consult doctor before consuming the drug.
Severely interacts with other drugs like
T Zine 10mg Tablet, Serta 100mg Tablet, Paropex 12.5mg Tablet CR, Osmoset 50mg Tablet

Missed Dosageuses

If you miss a dose of Duloxetine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Patient Concerns

Frequently asked questions for Combac 30mg Tablet

Frequently asked questions for Duloxetine

No. Combac is not a non-steroidal anti-inflammatory drug (NSAID). It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
No. Combac is not a steroid. It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
No. Combac is not a blood thinner. Blood thinners prevent the formation of harmful blood clots.
No. Combac is not a stimulant. Stimulants are the medicines which activate the central nervous system.
No. Combac is not a classical painkiller e.g. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).Duloxetine is used for the treatment of chronic pain conditions like neuropathic pain, diabetic neuropathy or fibromyalgia.
No. Combac is not a tricyclic antidepressant (TCA). It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).
No. Combac is not a benzodiazepine. It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Benzodiazepines belong to the sedative-hypnotic class of drugs and include agents like diazepam, lorazepam, alprazolam etc.
No. Combac is not a narcotic. It means it does not have habit-forming potential. Narcotics are the substance which can cause addiction and dependence.
Yes. A psychotropic is a medicine that affects mind, emotions, and behaviour. Combac, being an anti-depressant agent reduces the symptoms of depression and is a psychotropic agent.
Combac should be used with caution in patients with Hepatitis C virus infection. Cases of liver injury, including severe elevations of liver enzymes (>10-times upper limit of normal), hepatitis, and jaundice have been reported with Combac. Taking Combac increases the risk of liver toxicity and fatty liver in Hepatitis C virus-infected patients.<br>
The maximum plasma concentration [Cmax] of Combac is 6 hours post oral dose. Food taken with Combac may delay the time to reach the peak plasma concentration from 6 to 10 hours. This may marginally decrease the extent of absorption (approximately 11%).
Q. Can I take Combac with Vitamin D?
Yes. Combaccan be taken with vitamin D. It does not have any known interaction with Vitamin D.
The elimination half-life of Combac ranges from 8 to 17 hours (mean 12 hours).
Q. Which is better in depression, Combac or fluoxetine?
Fluoxetine has not been found to be different in either tolerability or efficacy when compared with Combac in major depression. Combac is good for treating depression, anxiety and may help with chronic pain.
Q. Which is better Combac vs sertraline?
Combac and sertraline are found to be equally effective in the treatment of Major Depressive Disorder (MDD). Certain symptoms like agitation and anxiety are reduced better by sertraline. Combac has been found to be better than sertraline for neuropathic pain.
Q. Which is better for chronic pain, Combac or pregabalin?
In patients with fibromyalgia Combac is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Combac and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
Q. Which is better Combac or fluoxetine?
Combac has been found to be better for the treatment of chronic pain than Fluoxetine. Fluoxetine is good for treating depression and anxiety.
Q. Which is better for depression, Combac or mirtazapine?
Currently, there is not enough information to firmly recommend one antidepressant over another. However, both these drugs have been found to be safe and efficacious in the treatment of depression.
Q. Which is better for depression, Combac or venlafaxine?
Currently, there is not enough information to firmly recommend one antidepressant over another. Many doctors favour Combac over venlafaxine when pain conditions coexist with depression.
No. Combac is not a barbiturate. Barbiturates belong to the Sedative-Hypnotic class of drugs and are likely to have abuse potential.
Combac can cause difficulty in sleep (insomnia). Hence, it is advised to be taken in the morning than at night.
Usually, the action of Combac takes about three to four weeks to appear. Do not discontinue the therapy in between, thinking that it is not effective.
Overdose can occur at a doses as low as 1000 mg. Signs and symptoms of overdose (duloxetine alone or in combination with other medicinal products) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia.
Combac is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.
Q. Can I take Combac with amitriptyline?
It is better to avoid Combac and amitriptyline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Combac with sertraline?
It is better to avoid Combac and sertraline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Combac with tramadol?
Combac and tramadol together can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Please inform your doctor if you are taking any of these medicines before coming to him.
Q. Can I take Combac with bupropion?
Bupropion can cause inhibition of metabolism of Combac in the body, resulting in toxic effects of Duloxetine. The concomitant use of these two drugs can result in seizures. Mention it to your doctor if you are taking any of these medications from before.
Q. Which is better in diabetic neuropathy, duloxetine or pregabalin?
In patients with fibromyalgia, Combac is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Combac and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
No. Combac does not cause a high. It does not create a feeling of euphoria and has no recreational potential.
Combac is not approved for the treatment of arthritis. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
No, Combac is not approved for the treatment of sciatica. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Obsessive-compulsive disorder (OCD) is a type anxiety disorder. It is approved for the treatment of obsessive-compulsive disorder. Research studies suggest that Combac may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder.
No. Combac is not approved for use in hot flashes. It may be used in the treatment of depression in postmenopausal women suffering from menopausal vasomotor symptoms (hot flashes, night sweats) and insomnia.
No, Duloxetine is not approved for use in headaches. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
No. Combac is not approved for use in a migraine. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Combac is approved for the treatment of chronic pain states including neuropathic pain (nerve pain) associated with Diabetes Mellitus and fibromyalgia.
Yes. Combac is approved for use in nerve pain or neuropathic pain conditions, most commonly seen in patients suffering from Diabetes Mellitus.
No. Combac may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.
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Substitutes for Combac Tablet

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