Comantrel 100 Capsule

Amantadine (100mg)

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Comantrel 100 Capsule is used alone or in combination with other medicines to treat Parkinson’s disease. It works by increasing the levels of a chemical called dopamine in the brain, which is important for controlling movement.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Jan 2026 | 11:12 AM (IST)

₹93.2 MRP ₹103.1310% off

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General Information

Contains

Amantadine (100mg)

Marketer

Consern Pharma Limited

Storage

Store below 30°C

The content is shown in English

Product introduction

Comantrel 100 Capsule helps in improving muscle control and reducing stiffness by affecting specific brain chemicals. Take Comantrel 100 Capsule as prescribed by your doctor, with or without food, preferably at the same time each day, to maintain a steady level of the medicine in your body. It can also be used to treat drug-induced movement disorders.

Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember it. You should finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to your doctor.

Some common side effects of Comantrel 100 Capsule include nausea, dizziness, and insomnia (difficulty sleeping). If you experience dizziness, rise slowly and do not drive or do anything that requires mental focus until you know how this medicine affects you.

This medicine may put you at a higher risk of having seizures, so talk to your doctor if you have any history of seizures or if you are taking any medication for seizures. Pregnant or breastfeeding women should consult a doctor before taking this medicine to make sure it is safe for them.

Uses of Comantrel Capsule

Parkinson's disease

Benefits of Comantrel Capsule

Parkinson's disease
Parkinson’s disease is a long-term brain condition that affects movement, causing symptoms like tremors, stiffness, and slowed body movements. Comantrel 100 Capsule helps manage these symptoms by improving mobility and reducing shakiness or stiffness. This makes daily activities easier and improves the overall quality of life for people living with Parkinson’s.

Side effects of Comantrel Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Comantrel

Dizziness
Insomnia (difficulty in sleeping)
Nausea

How to use Comantrel Capsule

Take this medicine in the dose and duration as advised by your doctor. Comantrel 100 Capsule may be taken with or without food.

How Comantrel Capsule works

Comantrel 100 Capsule works by increasing the levels of certain brain chemicals, such as dopamine, that help control movement and coordination. It helps improve muscle function, reduce stiffness, and enhance mobility in people with Parkinson’s disease and other movement disorders. It restores dopamine balance in the brain, making it easier to perform daily activities with better control and comfort.

Quick tips

Comantrel 100 Capsule may cause blurring of vision or affect mental ability. Do not drive or do anything requiring concentration until you know how it affects you.
To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Comantrel 100 Capsule may put you at a higher risk of having seizures. Talk to your doctor if you have a history of seizures or are taking medication for it.
Inform your doctor if you experience compulsive behaviors like gambling, increased sexual urges, binge eating, or overspending, as Comantrel 100 Capsule may affect dopamine levels and cause impulse control issues.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Comantrel 100 Capsule.

Pregnancy

CONSULT YOUR DOCTOR

Comantrel 100 Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Comantrel 100 Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Comantrel 100 Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Comantrel 100 Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Comantrel 100 Capsule is not recommended in patients with severe kidney disease.

Liver

CAUTION

Comantrel 100 Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.
It may cause a transient increase in liver enzymes.

Interaction with drugs

Taking Comantrel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Memantine (Oral Route)

Do not consume Memantine with Amantadine. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Bupropion (Oral Route)

Careful consideration is advised when taking Bupropion with Amantadine. If concurrent use is essential, watch out for symptoms such as shortness of breath, headache, nausea or blurred vision and consult your doctor if you experience them.

Moderate

Amisulpride (Oral Route)

If concurrent use is essential, watch out for symptoms such as constipation, confusion or psychosis and consult your doctor if you experience them. They may monitor your treatment and adjust the doses as per the observations. Amantadine may reduce efficacy of Amisulpride.

Moderate

Amisulpride (Injection Route)

Moderate

Aripiprazole (Oral Route)

Frequently asked questions

Can Comantrel 100 Capsule get you high?

The use of Comantrel 100 Capsule may cause impulse control disorders in which you may have strong urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and other intense urges. Additionally, there is the inability to control these urges. If such symptoms are experienced, then dose reduction or tapered discontinuation should be considered.

Is Comantrel 100 Capsule a dopamine agonist?

Yes, Comantrel 100 Capsule is a dopamine agonist. Dopamine is needed to control movements in the brain. Comantrel 100 Capsule works by increasing the amount of dopamine, thereby helping in controlling the movements in Parkinson’s disease.

Does Comantrel 100 Capsule cause fatigue?

Yes, Comantrel 100 Capsule causes fatigue and sleepiness, which may affect some patients’ ability to drive and operate machinery safely.

Can I take Comantrel 100 Capsule any time during the day? Should the dose be taken before meal?

Comantrel 100 Capsule can be taken at any time during the day, with or without food. Try to take the medicine at about the same time each day, as directed by your doctor. Taking your medicine at the same time each day will have the best effect. It will also help you remember when to take your medicine.

Is Comantrel 100 Capsule used for pain?

Though it is not an approved use, Comantrel 100 Capsule is effective in relieving pain related to nerve disorders. Comantrel 100 Capsule is a prescription medicine, and you should take it for the relief of pain only if advised by the doctor.

What happens when I stop taking Comantrel 100 Capsule?

Do not stop taking this medicine or lower the dose without first checking with your doctor. If required, your doctor will gradually reduce the amount you take each day before stopping it completely. Abruptly stopping Comantrel 100 Capsule may result in worsening of Parkinsonism. It may also cause delirium, agitation, delusions, hallucinations, paranoid reactions, stupor, anxiety, depression, or slurred speech.

Can Comantrel 100 Capsule cause weight loss?

A decrease in weight and body mass index may occur with continued Comantrel 100 Capsule usage. If you have any concerns regarding weight loss, consult your doctor or a nutritionist.

Fact Box

Chemical Class

Monoalkylamines

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

NMDA (N-methyl-D-aspartate) Receptor Antagonists

References

Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 477.
Standaert DG, Roberson ED. Treatment of Central Nervous System Degenerative Disorders. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 619.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 48-49.
Amantadine [Prescribing Information]. Bridgewater, New Jersey: Vertical Pharmaceuticals, LLC; 1966 [revised Feb. 2018]. [Accessed 19 Jun. 2019] (online) Available from:
Amantadine hydrochloride [Prescribing Information]. North Ryde, New South Wales: NOVARTIS Pharmaceuticals Australia Pty Limited; 2014. [Accessed 19 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Amantadine Hydrochloride [Product Information]. Maple Grove, MN: Upsher-Smith Laboratories, LLC; 2022. [Accessed 09 Jun 2023] (online) Available from:
Amantadine Hydrochloride [Product Information]. Ahmedabad, Gujarat: Zydus Lifesciences Ltd.; 2025. [Accessed 14 Mar. 2025] (online) Available from:

User feedback

Patients taking Comantrel 100 Capsule

Twice A Day

57%

Thrice A Day

29%

Once A Day

14%

What are you using Comantrel Capsule for?

Influenza (flu)

33%

Others

33%

Parkinson's disease

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Consern Pharma Limited
Address: 70-71, Ramnik Estate, Village Gonspur, P.O. Nurpur - 141008; H.O.: 308-C, BRS Nagar, Ludhiana, Punjab - 141012, India

Vendor Details

Country of origin: India

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Why we need a prescription?

Comantrel 100 Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Comantrel Capsule

Benefits of Comantrel Capsule

Side effects of Comantrel Capsule

How to use Comantrel Capsule

How Comantrel Capsule works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Memantine (Oral Route)

Bupropion (Oral Route)

Amisulpride (Oral Route)

Amisulpride (Injection Route)

Aripiprazole (Oral Route)

Frequently asked questions

Can Comantrel 100 Capsule get you high?

Is Comantrel 100 Capsule a dopamine agonist?

Does Comantrel 100 Capsule cause fatigue?

Can I take Comantrel 100 Capsule any time during the day? Should the dose be taken before meal?

Is Comantrel 100 Capsule used for pain?

What happens when I stop taking Comantrel 100 Capsule?

Can Comantrel 100 Capsule cause weight loss?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Comantrel 100 Capsule

What are you using Comantrel Capsule for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

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