Colisig 2 Injection

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:05 PM (IST)

Colisig 2 Injection is an antibiotic that fights bacteria. It is used to treat severe infections of the lungs, stomach, urinary tract, blood, and others. It works by killing the bacteria that cause these problems. It is commonly used to treat critically ill patients admitted to the hospital.

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General Information

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Product introduction

Colisig 2 Injection is given under the supervision of a healthcare professional. You should not self-administer this medicine at home. The dose and duration will be decided by your doctor based on the severity and type of infection you have. Get the injection regularly for as long as your doctor has prescribed to get maximum benefits.

It may cause pain, swelling, or redness at the site of injection. However, these are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away. It can even cause kidney damage in some people. You might need to be monitored while on this medication.

Before starting treatment with this medicine, you should tell the doctor if you are allergic to any antibiotic or have any liver or kidney problems. Pregnant or breastfeeding mothers should consult their doctor before using it. Your doctor may get regular blood tests done to monitor kidney function and the level of the medicine in your blood.

Uses of Colisig Powder for Injection

Treatment of Severe bacterial infections

Benefits of Colisig Powder for Injection

Treatment of Severe bacterial infections
Colisig 2 Injection is an antibiotic that is used to treat certain bacterial infections such as stomach and intestinal infections. It works by killing bacteria causing infections. Take it in the exact dose and duration as prescribed by your doctor. This medicine usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Colisig Powder for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Colisig

Diarrhea
Kidney damage
Nausea
Vomiting

How to use Colisig Powder for Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Colisig Powder for Injection works

Colisig 2 Injection is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.

Quick tips

It is given by a drip or by injection into the vein under the supervision of a doctor.
It may also be used to kill the natural bacteria that are present in the stomach before surgery on the stomach.
Do not use it for any other types of bacterial infections.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.

Safety advice

Alcohol

SAFE

Consuming alcohol with Colisig 2 Injection does not usually cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Colisig 2 Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

SAFE IF PRESCRIBED

Colisig 2 Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

SAFE

Colisig 2 Injection does not usually affect your ability to drive.

Kidney

CAUTION

Colisig 2 Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Colisig 2 Injection in patients with liver disease.

Interaction with drugs

Taking Colisig with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Capreomycin (Injection Route)

If concurrent use is essential, your doctor may monitor your blood pressure frequently.

Severe

Vancomycin (Injection Route)

If concurrent use is essential, your doctor may closely monitor your kidney's functioning and overall treatment.

Severe

Amikacin (Injection Route)

Do not consume Colistin Sulphate with Amikacin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Severe

Gentamicin (Injection Route)

Do not consume Colistin Sulphate with Gentamicin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Severe

Kanamycin (Injection Route)

Do not consume Colistin Sulphate with Kanamycin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

What should I tell my doctor before taking Colisig 2 Injection?

Before taking Colisig 2 Injection, you must tell your doctor if you have or ever had any problems related to your kidneys or liver. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Who should not use Colisig 2 Injection?

Use of Colisig 2 Injection should be avoided in patients who are allergic to Colisig 2 Injection or any of its components. However, if you are not aware of any allergy or if you are using Colisig 2 Injection for the first time, consult your doctor.

Can I take Colisig 2 Injection in pregnancy?

Enough evidence is not available to provide clarity on the use of Colisig 2 Injection in pregnancy. However, if you are pregnant or planning to conceive, consult your doctor before taking Colisig 2 Injection. You may take it only if prescribed by your doctor.

Is Colisig 2 Injection safe?

Colisig 2 Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Is Colisig 2 Injection effective?

Colisig 2 Injection is effective if used in the dose and duration advised by your doctor. Do not stop taking it even if you see improvement in your condition. If you stop using Colisig 2 Injection too early, the symptoms may return or worsen.

What if I forget to take a dose of Colisig 2 Injection?

If you forget a dose of Colisig 2 Injection, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose at the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Cell membrane active agent

Related lab tests

Complete Blood Count

References

Huang J, Tang YQ, Sun JY. Intravenous colistin sulfate: a rarely used form of polymyxin E for the treatment of severe multidrug-resistant Gram-negative bacterial infections. Scand J Infect Dis. 2010;42(4):260-5. [Accessed 30 Jan. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Signity Pharmaceuticals Pvt Ltd
Address: PLOT NO. 10, FLAT NO. 1, GROUND FLOOR DNYANYOG APARTMENT, DEO NAGAR, KHAMLA ROAD NAGPUR Nagpur MH 440015 IN , - , .

Vendor Details

Country of origin: India

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Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Colisig 2 Injection

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Colisig Powder for Injection

Benefits of Colisig Powder for Injection

Side effects of Colisig Powder for Injection

How to use Colisig Powder for Injection

How Colisig Powder for Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Capreomycin (Injection Route)

Vancomycin (Injection Route)

Amikacin (Injection Route)

Gentamicin (Injection Route)

Kanamycin (Injection Route)

Frequently asked questions

What should I tell my doctor before taking Colisig 2 Injection?

Who should not use Colisig 2 Injection?

Can I take Colisig 2 Injection in pregnancy?

Is Colisig 2 Injection safe?

Is Colisig 2 Injection effective?

What if I forget to take a dose of Colisig 2 Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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