Colestone 200mg Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Colestone 200mg Tablet is an anti-progestational steroid class of drug used for medical termination of pregnancy. It works by blocking the action of progesterone, an essential hormone for the development of pregnancy.

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General Information

Contains

Mifepristone (200mg)

Marketer

Zenlabs Ethica Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Colestone 200mg Tablet is given alone or in combination with some other medicine to attain the maximum benefit. It can be taken with or without food or as your doctor's advice. It should be taken orally, by swallow the tablets whole with a glass of water. If you experience vomiting within 45 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24- 48 hours to show its action and you experience bleeding.

The most common side effects of this medicine include nausea, vomiting, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. If you experience heavy vaginal bleeding or abdominal pain on taking this medicine, you should inform your doctor immediately.

Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using an intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running, and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion.

Uses of Colestone Tablet

Medical abortion

Benefits of Colestone Tablet

Medical abortion
Colestone 200mg Tablet is used for medical abortion as a safe and non-surgical option to end early pregnancy. It works by blocking the hormone progesterone, which is essential for pregnancy continuation. This allows the uterus to shed its lining, helping to end the pregnancy in a controlled and less invasive way.

Side effects of Colestone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Colestone

Nausea
Vomiting
Diarrhea

How to use Colestone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Colestone 200mg Tablet may be taken with or without food.

How Colestone Tablet works

Colestone 200mg Tablet blocks the effects of progesterone, a natural female hormone which is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy.

Quick tips

Colestone 200mg Tablet helps in medical termination of pregnancy.
If you vomit within 45 minutes of taking the tablet, talk to your doctor immediately. You will need to take another tablet.
Take it only as prescribed by the doctor. Miscarriages, if incomplete, may result in serious medical complications leading to hospitalization, surgery and possible infertility.
Be cautious while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
It does not affect fertility. Use contraception to avoid pregnancy.
Take it no later than 63 days after the first day of your last menstrual period.
Vaginal bleeding may or may not occur after taking this medicine. Inform your doctor immediately if excessive bleeding occurs or if you suffer from severe abdominal pain.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Colestone 200mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Colestone 200mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Colestone 200mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Colestone 200mg Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Colestone 200mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Colestone 200mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Colestone with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Apalutamide (Oral Route)

Concurrent use should be avoided. Please consult with your doctor. Apalutamide may increase the metabolism of Mifepristone.

Severe

Dexibuprofen (Oral Route)

Do not consume Mifepristone with Dexibuprofen. Dexibuprofen may reduce the efficacy of Mifepristone.

Moderate

Acalabrutinib (Oral Route)

Persistant concurrent use may increase blood levels of Acalabrutinib.

Moderate

Allylestrenol (Oral Route)

In case of Cushing's syndrome, your doctor may recommend you to use non-hormonal forms of contraception like, condoms during treatment and for 1 month after stopping Allylestrenol. Mifepristone may reduce efficacy of Allylestrenol.

Moderate

Alprazolam (Oral Route)

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam accordingly. Mifepristone may raise blood levels of Alprazolam.

Frequently asked questions

What is Colestone 200mg Tablet and what it is used for?

Colestone 200mg Tablet contains a medicine called Mifepristone. It helps in medical termination of the pregnancy. It works by blocking the effect of progesterone (a female sex hormone) which is required for maintenance of pregnancy. It is only used to terminate a pregnancy which should not be more than 63 days old, counting from the first day of the last menstrual period.

How and in what dose should I use Colestone 200mg Tablet?

Colestone 200mg Tablet can be taken orally with a glass of water. It should be taken under the supervision of a doctor.

What should I expect after taking Colestone 200mg Tablet?

You may or may not experience vaginal bleeding or spotting after taking this medicine. After 48 hours of taking Colestone 200mg Tablet, your doctor shall examine you and may prescribe you another medicine (Misoprostol) for complete termination of pregnancy. After 14 days of taking Colestone 200mg Tablet, your gynaecologist may run some blood tests or perform ultrasonography to confirm whether the pregnancy has been terminated or not.

Can Colestone 200mg Tablet affect my future chances of getting pregnant?

No, studies have shown that this medicine does not impair the fertility of the women. Your future chances of getting pregnant are as equal as of those who have not taken this medicine.

Fact Box

Chemical Class

Oxosteroids

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Antiprogestins

References

Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1184-85.
Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 716-17.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 916-19.
Mifepristone. Menlo Park, California: Corcept Therapeutics Incorporated; 2000. [Accessed 03 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from:
Mifepristone. Las Vegas, NV: GenBioPro, Inc.; 2023 [Accessed 12 Feb. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zenlabs Ethica Ltd
Address: Plot No. 194-195, 3rd Floor, Industrial Area, Phase-II, Chandigarh (India) - 160002

Vendor Details

Country of origin: India

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Colestone 200mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Colestone Tablet

Benefits of Colestone Tablet

Side effects of Colestone Tablet

How to use Colestone Tablet

How Colestone Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Apalutamide (Oral Route)

Dexibuprofen (Oral Route)

Acalabrutinib (Oral Route)

Allylestrenol (Oral Route)

Alprazolam (Oral Route)

Frequently asked questions

What is Colestone 200mg Tablet and what it is used for?

How and in what dose should I use Colestone 200mg Tablet?

What should I expect after taking Colestone 200mg Tablet?

Can Colestone 200mg Tablet affect my future chances of getting pregnant?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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