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Mifepristone is used for medical termination of an early pregnancy. It is also used to control excessive blood sugar level in patients with Cushing's syndrome (a disease where the hormone cortisol rises in the body due to tumour of adrenal gland) in patients who have failed surgery or are not candidates for surgery.

How it works

Mifepristone is an anti-progesterone hormone that acts by blocking the effects of progesterone, a hormone which is needed for pregnancy to continue.

Common side effects

Vomiting, Nausea, Altered menstrual cycle, Joint pain, Diarrhoea, Dizziness, Fatigue, Headache, Decreased potassium level in blood, Insomnia, Limb swelling, Loss of appetite, Weakness


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Expert advice

  • In case of heavy and prolonged bleeding, or if the expulsion has occurred before you took prostaglandin, you should contact the doctor immediately to ensure complete evacuation.
  • If pregnancy continues or expulsion is incomplete, you will be offered another method for terminating the pregnancy.
  • Do not take mifepristone If  you are allergic (hypersensitive) to the active substance mifepristone or prostaglandin (if required to be taken  together) any of the other ingredients of the medicine.
  • Because mifepristone may pass into breast milk and be taken in by your baby, you should stop in case you were breastfeeding once you have taken the treatment.

Frequently asked questions


Q. Can you take mifepristone with water?
Misoprostol can be ingested orally with water.
Q. Is mifepristone and misoprostol available/ legal in India?
Yes,it is available in India,but it should only be used as per doctor’s advice.
Q. Can I take ibuprofen with mifepristone?
Mifepristone may increase the blood levels and effects of ibuprofen, even after you have stopped taking mifepristone for a while.You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

Content on this page was last updated on 04 October, 2016, by Dr. Varun Gupta (MD Pharmacology)