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Clomipramine(25 mg)


Clomipramine(25 mg)


Clomipramine is used in adults to treat obsessive compulsive disorder (mental condition characterized by unwanted thoughts and repetitive behavior). It is also used to treat muscular weakness (cataplexy) associated with repeat attacks of extreme sleepiness (narcolepsy).

How it works

Clomipramine belongs to the group of medicines called tricyclic antidepressants. It acts by restoring the balance of chemical substances (serotonin) present in the brain.

Common side effects

Dizziness, Anxiety, Disorientation, Hypomania, Urinary retention, Hair loss, Low blood pressure with change of position, Loose motions, Headache, Fatigue, Itching of skin, Sleepiness, Bleeding vessels near the skin surface, Vomiting, Increased blood pressure, Muscular weakness, Anaphylactic reactions including hypotension, Most, Agitation, Reddish-purple discoloration of skin due to small, Blurred vision, Abnormal increase in sweating, Hot flush, Skin allergies, Seeing or hearing things that are not really there, Unpleasant dreams, Abnormal sensations of skin, Memory impairment, Abnormal milky discharge from the breasts, Problems with erection, Altered taste sensation, Unable to sleep, Increased weight, Thumping, Increased appetite, Swelling, Sleep disorder, Sensitivity to sunlight, Decreased appetite, Aggravation of depression, Depersonalisation, Involuntary muscle jerks, Abdominal disorders, Fits, Uncontrolled shaking, Breast enlargement, Increase in liver enzymes, Restlessness, Disturbance in attention, Muscle Hypertonia, Increased pressure inside the eye causing visual problems, Abnormal ECG changes, Yawning, Neuroleptic malignant syndrome, Problem in passing urine, Ringing in ears, Mania, Dilatation of the pupil of the eye, Speech disorder, Acute confusional state, Aggression, Siadh, Heartbeat related disorder, Hepatitis with or without jaundice, Unsteady movement, Sexual activity disorder, Abnormal electroencephalogram, Pounding or fluttering sensation in chest, Pneumonitis with or without eosinophilia, Abnormally high fever, Activation of psychotic symptoms


16 Substitutes
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    (10 tablet in strip)
    Intas Pharmaceuticals Ltd
    Rs. 6.25/tablet
    Rs. 62.50
    save 5% more per tablet
    (10 tablet in strip)
    Talent Healthcare
    Rs. 5.04/tablet
    Rs. 50.40
    save 24% more per tablet
    (10 tablet in strip)
    La Pharmaceuticals
    Rs. 5.17/tablet
    Rs. 51.70
    save 22% more per tablet
    (10 tablet in strip)
    Triko Pharmaceuticals
    Rs. 4.70/tablet
    Rs. 47
    save 29% more per tablet
    (10 tablet in strip)
    Psychotropics India Ltd
    Rs. 2/tablet
    Rs. 20.02
    save 70% more per tablet

Expert advice

  • Do not start or continue clomipramine tablets, if you are allergic (hypersensitive) to tricyclic antidepressants, clomipramine or any of the other ingredients of clomipramine medication.
  • Do not take clomipramine if you have history of suicide-related events.
  • Avoid using clomipramine if you are pregnant or breast feeding.
  • Advice care givers to monitor the patient carefully.
  • Doctor’s advice should be considered in case of following disease conditions: heart disorders, serotonin syndrome, fits (convulsions), increased pressure inside the eye causing visual problems (narrow angle glaucoma), urinary retention, liver disease, and chronic constipation.

Frequently asked questions


Q. Is clomipramine safe?
Clomipramine is safe if used at prescribed dose and duration as advised by your doctor.

Q. Is clomipramine a MAOI/anticholinergic/benzodiazepine/SSRI/narcotic?
Clomipramine is tricyclic antidepressant. It treats depression through inhibiting the neuronal re-uptake of chemical substances present in the brain called noradrenaline and mainly serotonin (SSRI). It is not MAOI/anticholinergic/benzodiazepine/narcotic.

Q. Is clomipramine a controlled substance?
No, it is not a controlled substance.

Q. Is clomipramine addictive?
Clomipramine is not addictive if used at prescribed dose and duration as advised by your doctor.

Q. Can I take paracetamol/diazepam/5htp with clomipramine?
Taking other medicines may alter the effects of clomipramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.

Q. Does clomipramine cause weight loss/weight gain/make you sleepy/cause constipation/affect fertility?
Clomipramine may cause these side effects; effect on fertility is very rare side effect. However, consult your doctor if you experience any of these side effects.

Q. Does clomipramine help premature ejaculation?
Clomipramine effectively increases ejaculatory latency in men with primary premature ejaculation, while treatment is not effective in those with premature ejaculation and erectile dysfunction.

Q. Does clomipramine work for obsessive-compulsive disorder (OCD)?
Yes, clomipramine is used for obsessive-compulsive disorder. Patients should follow the advice of the doctor regarding its use.

Content on this page was last updated on 29 April, 2016, by Dr. Khoobsurat Najma (Senior Content Writer)