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Clomipramine(25 mg)


Clomipramine(25 mg)


Clomipramine is used in adults to treat obsessive compulsive disorder (mental condition characterized by unwanted thoughts and repetitive behavior). It is also used to treat muscular weakness (cataplexy) associated with repeat attacks of extreme sleepiness (narcolepsy).

How it works

Clomipramine belongs to the group of medicines called tricyclic antidepressants. It acts by restoring the balance of chemical substances (serotonin) present in the brain.

Common side effects

hot flush.Very rare: change in blood cell count, hypomania, disorientation, dizziness, hair loss, increase in liver enzymes, low blood pressure with change of position, increased blood pressure, activation of psychotic symptoms., muscular weakness, anaphylactic reactions including hypotension, reddish-purple discolouration of skin due to small, agitation, skin allergies, abnormal sensations of skin, unpleasant dreams, abnormal milky discharge from the breasts, memory impairment, sleepiness, problems with erection, unable to sleep, seeing or hearing things that are not really there, pneumonitis with or without eosinophilia, increased weight, loose motions, thumping, altered taste sensation, increased appetite, sensitivity to sunlight, itching of skin, aggravation of depression, decreased appetite, depersonalisation, involuntary muscle jerks, vomiting, abdominal disorders, breast enlargement, abnormally high fever, uncontrolled shaking, disturbance in attention, Most common: accommodation disorder, swelling, muscle hypertonia, abnormal increase in sweating .Common: increased heart rate, increased pressure inside the eye causing visual problems, abnormal ECG changes, sleep disorder, yawning, bleeding vessels near the skin surface .Uncommon: change from normal heartbeat, problem in passing urine, restlessness, ringing in ears, neuroleptic malignant syndrome, fatigue, mania, dilatation of the pupil of the eye, speech disorder, urinary retention, acute confusional state, pounding or fluttering sensation in chest, aggression, SIADH, blurred vision, heartbeat related disorder, hepatitis with or without jaundice, fits, anxiety, headache, unsteady movement, sexual activity disorder, abnormal electroencephalogram


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Expert advice

  • Do not start or continue clomipramine tablets, if you are allergic (hypersensitive) to tricyclic antidepressants, clomipramine or any of the other ingredients of clomipramine medication.
  • Do not take clomipramine if you have history of suicide-related events.
  • Avoid using clomipramine if you are pregnant or breast feeding.
  • Advice care givers to monitor the patient carefully.
  • Doctor’s advice should be considered in case of following disease conditions: heart disorders, serotonin syndrome, fits (convulsions), increased pressure inside the eye causing visual problems (narrow angle glaucoma), urinary retention, liver disease, and chronic constipation.

Frequently asked questions


Q. Is clomipramine safe?
Clomipramine is safe if used at prescribed dose and duration as advised by your doctor.

Q. Is clomipramine a MAOI/anticholinergic/benzodiazepine/SSRI/narcotic?
Clomipramine is tricyclic antidepressant. It treats depression through inhibiting the neuronal re-uptake of chemical substances present in the brain called noradrenaline and mainly serotonin (SSRI). It is not MAOI/anticholinergic/benzodiazepine/narcotic.

Q. Is clomipramine a controlled substance?
No, it is not a controlled substance.

Q. Is clomipramine addictive?
Clomipramine is not addictive if used at prescribed dose and duration as advised by your doctor.

Q. Can I take paracetamol/diazepam/5htp with clomipramine?
Taking other medicines may alter the effects of clomipramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.

Q. Does clomipramine cause weight loss/weight gain/make you sleepy/cause constipation/affect fertility?
Clomipramine may cause these side effects; effect on fertility is very rare side effect. However, consult your doctor if you experience any of these side effects.

Q. Does clomipramine help premature ejaculation?
Clomipramine effectively increases ejaculatory latency in men with primary premature ejaculation, while treatment is not effective in those with premature ejaculation and erectile dysfunction.

Q. Does clomipramine work for obsessive-compulsive disorder (OCD)?
Yes, clomipramine is used for obsessive-compulsive disorder. Patients should follow the advice of the doctor regarding its use.

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