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Cloff 500 Tablet

Clarithromycin (500mg)

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Cloff 500 Tablet is an antibiotic used to treat various types of infections. It is effective in most infections of the respiratory tract, ear, nose, throat, lungs, and skin. It is also effective against a bacteria known as H. pylori, which is associated with peptic ulcer disease.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 14 Apr 2026 | 04:20 PM (IST)

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General Information

Contains

Clarithromycin (500mg)

Marketer

Alembic Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Cloff 500 Tablet is also effective against some infections (e.g., MAC or Mycobacterium avium complex) seen in people with reduced immunity. It stops the bacteria from growing, which helps to resolve your symptoms and cure your infection. This medicine is taken orally, preferably either one hour before or 2 hours after a meal. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.

Common side effects with this medicine include diarrhea, nausea, indigestion, abdominal pain, headache, vomiting, and rash. These are usually temporary and subside with the completion of treatment. Consult your doctor if you find these side effects do not resolve or persist for a longer duration.

Inform your doctor if you have any previous history of allergy or heart problems before taking this medicine. Pregnant or breastfeeding women should consult their doctor before using this medicine.

Uses of Cloff Tablet

Treatment of Bacterial infections

Benefits of Cloff Tablet

Treatment of Bacterial infections
Cloff 500 Tablet is an antibiotic medicine that can be used to treat many different infections caused by bacteria. These include infections of the respiratory tract, ear, nose, throat, lungs, and skin. It is also effective against a bacteria known as H. pylori, which is associated with peptic ulcer disease. It stops further growth of the bacteria causing the infection and helps treat your infection.

This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed even when you feel better, to make sure that all bacteria are killed and do not become resistant.

Side effects of Cloff Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cloff

Abdominal pain
Diarrhea
Insomnia (difficulty in sleeping)
Nausea
Vomiting
Headache
Taste change
Rash
Abnormal liver function tests

How to use Cloff Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cloff 500 Tablet may be taken with or without food.
Avoid Cloff 500 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Cloff Tablet works

Cloff 500 Tablet is an antibiotic. It works by preventing synthesis of essential proteins required by bacteria to carry out vital functions. Thus, it stops the bacteria from growing, and prevents the infection from spreading.

All substitutes for Cloff 500 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Your doctor has prescribed Cloff 500 Tablet to cure your infection and improve your symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
Take it 1 hour before or two hours after food.
Do not take antacids 2 hours before or after taking Cloff 500 Tablet.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
Stop taking Cloff 500 Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Cloff 500 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Cloff 500 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Cloff 500 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

CONSULT YOUR DOCTOR

It is not known whether Cloff 500 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Cloff 500 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Cloff 500 Tablet in patients with liver disease.

Interaction with drugs

Taking Cloff with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Pimozide (Oral Route)

Do not consume Pimozide with Clarithromycin.

Life-threatening

Ranolazine (Oral Route)

Do not consume Clarithromycin with Ranolazine. Clarithromycin may raise blood levels of Ranolazine.

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Clarithromycin.

Life-threatening

Simvastatin (Oral Route)

Do not consume Simvastatin with Clarithromycin. If Clarithromycin is essential, your doctor may temporarily stop Simvastatin. Clarithromycin may raise blood levels of Simvastatin.

Life-threatening

Ivabradine (Oral Route)

Do not consume Ivabradine with Clarithromycin. Clarithromycin may raise blood levels of Ivabradine.

Frequently asked questions

Can the use of Cloff 500 Tablet cause diarrhea?

Yes, the use of Cloff 500 Tablet can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.

How long does Cloff 500 Tablet takes to work?

Usually, Cloff 500 Tablet starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

What if I don't get better after using Cloff 500 Tablet?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

Can the use of Cloff 500 Tablet cause infertility?

There is no firm evidence to suggest that the use of Cloff 500 Tablet will cause infertility in males or females.

Fact Box

Chemical Class

Aminoglycosides

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Macrolides

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Chambers HF, Deck DH. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidiones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 800-801.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 287-89.
Clarithromycin. Birzebbugia, Malta: APL Swift Services (Malta) Limited; 2018. [Accessed 11 Feb. 2019] (online) Available from:
Clarithromycin. Jacksonville, Florida: Ranbaxy Pharmaceuticals Inc; Jul. 2007. [Accessed 31 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:
Clarithromycin [Drug Label]. North Chicago, IL: Abbott Laboratories; 2012. [Accessed 25 Jul. 2024] (online) Available from:
Clarithromycin [Drug Label]. Bantry Co. Cork, Ireland: Rowex Ltd; 2024. [Accessed 17 Jan. 2026] (online). Available from:

User feedback

Patients taking Cloff 500 Tablet

Twice A Day

83%

Once A Day

16%

Thrice A Day

What are you using Cloff Tablet for?

Bacterial infections

80%

Others

13%

Bacterial skin infections

How much was the improvement?

Average

58%

Poor

42%

What were the side-effects while using Cloff 500 Tablet?

No Side Effect

67%

Abdominal pain

33%

How do you take Cloff Tablet?

With food

67%

Empty stomach

33%

Please rate Cloff 500 Tablet on price

Average

67%

Expensive

33%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alembic Pharmaceuticals Ltd
Address: Alembic Road, Vadodara - 390 003, Gujarat,INDIA

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Cloff 500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Cloff 500 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Cloff Tablet

Benefits of Cloff Tablet

Side effects of Cloff Tablet

How to use Cloff Tablet

How Cloff Tablet works

All substitutes for Cloff 500 Tablet

Zoclar 500mg Tablet

Claribid 500 Tablet

Clarigard 500 Tablet

Clariwin 500 Tablet

Clarycin 500 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Pimozide (Oral Route)

Ranolazine (Oral Route)

Domperidone (Oral Route)

Simvastatin (Oral Route)

Ivabradine (Oral Route)

Frequently asked questions

Can the use of Cloff 500 Tablet cause diarrhea?

How long does Cloff 500 Tablet takes to work?

What if I don't get better after using Cloff 500 Tablet?

Can the use of Cloff 500 Tablet cause infertility?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

User feedback

Patients taking Cloff 500 Tablet

What are you using Cloff Tablet for?

How much was the improvement?

What were the side-effects while using Cloff 500 Tablet?

How do you take Cloff Tablet?

Please rate Cloff 500 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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