Assurans Injection is a phosphodiesterase (PDE-5) inhibitor. It works by relaxing the blood vessels in your lungs thereby reducing the high blood pressure in the lungs. This allows your heart to work less to pump blood in your lungs.

In Depth Information on Assurans Injection

Expert advice for Assurans Injection

Assurans Injection is used to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It can help improve your quality of life and exercise ability.
Assurans Injection may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
Do not use other medicines (nitrates or nitroglycerin) when taking Assurans Injection as it could drop your blood pressure to a dangerous level.
Do not consume alcohol while taking Assurans Injection as that may increase the blood pressure-lowering effects of Assurans Injection.
Stop taking Assurans Injection and immediately inform your doctor if you notice loss of vision in one or both eyes or sudden loss of hearing with ringing sensation in your ear.
If you have an erection, which lasts continuously for more than 4 hours, stop taking Assurans Injection and contact your doctor immediately.
Do not stop taking the medication suddenly without talking to your doctor as that may lead to worsening of your symptoms.

Assurans Injection related warnings

Special precautions for Assurans Injection

Alcohol

CAUTION

Taking Sildenafil with alcohol may lower blood pressure.

Pregnancy

PROBABLY SAFE

Assurans Injection is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Lactation

Assurans Injection is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.

Driving

Assurans Injection may make you feel dizzy, drowsy or affect your vision. Do not drive until your vision is clear.

Kidney

SAFE

Assurans Injection is safe to use in patients with kidney disease. No dose adjustment of Assurans Injection is recommended.
However, inform your doctor if you have any underlying kidney disease. A lowering of dose may be considered if it is not well-tolerated.

Liver

Assurans Injection should be used with caution in patients with severe liver disease. Dose adjustment of Assurans Injection may be needed. Please consult your doctor.
There is limited information available on the use of Assurans Injection in patients with severe liver disease.

Patient Concerns

Frequently asked questions about Assurans Injection

Frequently asked questions about Sildenafil

Q. How does Assurans work?

Assurans is a phosphodiesterase 5 inhibitor which works by relaxing the penile smooth muscles and by increasing the blood flow to the penis. It helps to achieve and maintain an erection but only if there is sexual stimulation.

Q. Is Assurans safe?

Yes, Assurans is safe if taken for prescribed duration in prescribed doses as advised by your doctor. However, there are some very common side effects that you can experience at effective doses like Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in Extremity.

Q. Is Assurans a steroid?

No, Assurans is not a steroid. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Is Assurans an over the counter product?

No, Assurans is not an over-the-counter product. You can buy it when it is prescribed by a doctor.

Q. Is Assurans a blood thinner?

No, Assurans is not a blood thinner. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Can I take Assurans for premature ejaculation?

Assurans is not known to have any beneficial effects of treating premature ejaculation. It is used for the treatment of erectile dysfunction.

Q. Can I take Assurans for the rest of my life?

Assurans is a prescription drug and should only be taken for the duration as advised by your doctor.

Q. Can I take Assurans in my twenties?

Yes, Assurans can be taken in the twenties. It is approved for use in adult men above the age of 18 who have erectile dysfunction. It should be taken after consulting a doctor and strictly as advised.

Q. Can I take Assurans with dapoxetine?

Yes, Assurans can be safely taken with dapoxetine. Assurans is useful for treating erectile dysfunction and dapoxetine is for premature ejaculation. A fixed dose combination of these medicines is available which is useful in patients suffering from both erectile dysfunction and premature ejaculation. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can I take Assurans with warfarin?

Assurans can be taken with warfarin, no significant drug interactions have been seen between the two. However, there have been some clinical reports of penile fracture in patients using Assurans with warfarin. Inform your doctor before taking the two drugs together.

Q. Can I take Assurans if I am also having high blood pressure?

Assurans can be taken in patients with high blood pressure. However, if you are taking medicines for high blood pressure, taking Assurans along with them can cause a significant fall in blood pressure which could be harmful. Assurans is absolutely contraindicated in patients taking nitrates. Inform your doctor before taking them together.

Q. Can I take Assurans with lisinopril?

Yes, Assurans can be taken with lisinopril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Assurans with ramipril?

Yes, Assurans can be taken with ramipril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Assurans with beta blockers?

Yes, Assurans can be taken with beta-blockers. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Assurans with amlodipine?

Yes, Assurans can be taken with amlodipine. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Does Assurans affect fertility?

No, Assurans is not known to affect fertility. It is used only for erectile dysfunction. For treatment of any fertility-related problems, please consult a doctor.

Q. Does Assurans affect sperm?

Assurans is not known to affect sperm (number or movement of sperms). It is a drug which is used for erectile dysfunction.

Q. Does Assurans increase blood pressure?

No, Assurans is not associated with an increase in blood pressure. It can cause a decrease in blood pressure especially if taken with other blood-pressure-lowering medications. Please consult your doctor before taking Assurans with any other medicine.

Q. Does Assurans delay ejaculation?

No, Assurans is not known to affect ejaculation.

Q. Does Assurans expire?

Assurans like any other medicine has an expiry date and should not be used beyond the date mentioned on the package.

Q. Why does Assurans cause a fall in blood pressure (hypotension)?

Assurans has the property of relaxing the smooth muscle of the blood vessels and widening them which can cause a fall in blood pressure (hypotension). So, when used with blood pressure lowering drugs or nitrates, it can cause a severe fall in blood pressure, which could be fatal. Assurans should not be taken if you are taking nitrates for chest pain or you have a history of heart attack or stroke in the past six months.

Q. Is Assurans safe to use in patients with diabetes?

Yes, Assurans is safe to use in patients with diabetes. Erectile dysfunction and is commonly reported by diabetic patients as diabetes is one of the most common causes of this condition. Long standing diabetes can damage the nerves in the body (neuropathy) including the nerves of the penis. It also harden and narrow the blood vessels which decreases the blood flow to the penis causing erectile dysfunction. Assurans is seen to be beneficial in treating erectile dysfunction (ED) in patients with diabetes mellitus.

Q. Why is the use of Assurans contraindicated with nitrates?

Use of Assurans is not recommended in patients taking nitrates (organic nitrates or organic nitrites) as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of Assurans and any nitrate substance.

Q. What are the serious side effects of Assurans?

Assurans can cause serious side effects like heart attack, sudden cardiac death, abnormal heart beat and bleeding in the brain tissues that can cause temporary or permanent brain damage. A patient can have chest pain during the intercourse and if this occurs, try to relax in a semi-sitting position and do not use any nitrate to relieve the chest pain. Rarely a sudden loss in vision and serious allergic skin reactions with fever, peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes can occur.

Q. Can I take Assurans for treating piles (hemorrhoids)?

No, Assurans is not indicated for the treatment of piles (hemorrhoids). Rather, its use has been reported to cause piles (hemorrhoids).

Q. Can Assurans be taken with losartan?

Yes, Assurans can be taken along with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Assurans with paracetamol?

Yes, Assurans can be taken with paracetamol. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can I take Assurans with aspirin?

Yes, Assurans can be taken with aspirin. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can Assurans increase the level of testosterone?

Yes, Assurans can increase the testosterone levels. It has a direct effect on the testes which can lead to an increase in the blood testosterone levels.

Q. Can Assurans cause persistent and painful erection of the penis (priapism)?

Assurans and other drugs used for the treatment of erectile dysfunction have been seen to cause prolonged erections and persistent and painful erection of the penis(priapism). In case the erection persists for more than 4 hours, immediately seek medical attention. If it is not treated immediately, penile tissue damage and permanent loss of potency can occur.

Q. Can Assurans be taken with itraconazole?

Assurans can be taken with itraconzole, however, a dose adjustment would be needed before taking them together. Assurans is metabolized (degraded) by an enzyme known as CYP3A4. Itraconazole decreases the working of this enzyme causing increased blood levels of Assurans and higher chances of having side effects.

Q. Can I take Assurans with tadalafil?

Both tadalafil and Assurans are phosphodiesterase inhibitors and act by dilating the blood vessels. Using them together would not give any additional benefit, rather they may cause a severe fall in blood pressure and a prolonged painful erection. Therefore, these two drugs should not be taken together.

Q. What is the benefit of taking Assurans with finasteride?

Yes, Assurans can be taken along with finasteride. This combination is beneficial in the treatment of benign prostatic hyperplasia (BPH). Finasteride is also known to cause erectile dysfunction as one of its side effects and Assurans can be used for the treatment of this problem along with finasteride.

Q. Can I take Assurans with Tamsulosin?

Special caution needs to be taken when Assurans is taken along with Tamsulosin. Both are known to decrease blood pressure and can also cause orthostatic hypotension (fall in blood pressure when standing from a sitting position). So, when taken together they can cause a severe fall in blood pressure which can be harmful.

Q. Is Assurans a prescription medicine?

Yes, Assurans is a prescription medicine and can be taken only when prescribed by the doctor.

Q. Can I take Assurans for fun?

Assurans is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with its own side effects.

Severely interacts with other drugs like

Taking Assurans with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Assurans with Nitroglycerin / Glyceryl Trinitrate

LIFE-THREATENING

Medicines with composition Nitroglycerin / Glyceryl Trinitrate: Leonite, Isonit GTN, Nitrogal, Nitrocare, Corodil, Myocare, Nitract, GTN, Winitro, Nitrowok, Angiplat, Angistat, Nitrocontin, Alnitro, Ntgn, Anglit, Angispan, Nitroject, New GTN, Nitrocin (Pen), Nitroglyn, Nitrosis, Top Nitro, Nig, Glytrate, Nitrospan, Monit GTN, Glyin, NG Long, Angised, Iskem GTN

Assurans with Isosorbide Dinitrate

LIFE-THREATENING

Medicines with composition Isosorbide Dinitrate: Sorbitrate, Isordil, Cardicap

Assurans with Nitroprusside

LIFE-THREATENING

Medicines with composition Nitroprusside: Nitoside

Assurans with Nicorandil

LIFE-THREATENING

Medicines with composition Nicorandil: Lorandil, Nicoranfic, Dilkor, Asnicor, Corflo, Nicopress, Nicorex, Nucoril, K-Ion, Korandil, Zynicor, K-Cor, Duorandil

Assurans with Isosorbide Mononitrate

LIFE-THREATENING

Medicines with composition Isosorbide Mononitrate: Monopark, Isotrate, Monex, Angitrate, Isopark, Angifree, Isobax, Monotrate, Solotrate, Monit, Isonorm, Imdur, Nitrofix, Nitrovas, Monosorbitrate, Vasotrate, Cardimon, Nitrofirst, Monosorbex, Monocontin, Angicor, Ismo, Olvisol, 5 Mono, Imnit, Monn, Oncid

Assurans with Naftopidil

SERIOUS

Medicines with composition Naftopidil: Nafodil

Assurans with Terazosin

SERIOUS

Medicines with composition Terazosin: Terapress, Vicard T

Assurans with Phenoxybenzamine

SERIOUS

Medicines with composition Phenoxybenzamine: Zaxyben

Assurans with Alfuzosin

SERIOUS

Medicines with composition Alfuzosin: Efzu, Alfutrol, Zyalfa, Alfusin, Alfoo

Assurans with Indinavir

SERIOUS

Medicines with composition Indinavir: Indivan

Assurans with Doxazosin

SERIOUS

Medicines with composition Doxazosin: Duracard

Assurans with Rifabutin

SERIOUS

Medicines with composition Rifabutin: Macbutin

Assurans with Bosentan

SERIOUS

Medicines with composition Bosentan: Lupibose, Bozetan, Bosentas, Pulvance

Assurans with Ritonavir

SERIOUS

Medicines with composition Ritonavir: Viriton, Ritomune, Ritomax

Assurans with Prazosin

SERIOUS

Medicines with composition Prazosin: Prazovin, Biozocin, Prazonol, Renopress, Minipress, Prazopill, Pracept, Resplend, Prazolin

Assurans with Silodosin

SERIOUS

Medicines with composition Silodosin: Silodonol, Sildosol, Silotime, Silorun, Silodal, Flospurt, Geripod, Rapilif, Sildoo, Silocap, Urief

Assurans with Tamsulosin

SERIOUS

Medicines with composition Tamsulosin: Tamocas, Tampros MR, Urivin, Temsunir, Prostop, Eaziflo, Tamlocept, Contiflo Icon, Tamflo, Geristart, Urimax, Alfatam, Tasulin, Dynapres, Tamcontin, Urinat, Uripro, Veltam, Monolosin, Bezip, Flodart, Urisurge

Assurans with Rifampicin

MODERATE

Medicines with composition Rifampicin: Coxbact, Rifacure, Rifacil, Toscular, Grifa, Tubercin, Car, Acirimpi, Osorifa, Serom, Monocin, Rifacept, R-Cin, Montomycin

Assurans with Erythromycin

MODERATE

Medicines with composition Erythromycin: Arthrox, Ciresto, Eromax, Avithrocin, Denthrocin, E Cin, T Mycin, Suzithrocin, Methro, Erypsin, Eryn, Enzycare, Erigyn, Osomycin, Eromycin, Ortholate, Althrocin, Eryster, Eryspic, Elthrocin, Etomin, Erythrocin, Erypal, Erythrokem, Agrocin, Eltocin, Eryspans, Elucin, EB, Erycon, Q Mycin, Erythrotone, Erythrol, Citamycin, Eroate, Erythromark, Citamycin P, E Mycin, Erytho, Erythromycin Estol

Assurans with Spiramycin

MODERATE

Medicines with composition Spiramycin: Spiramycin, Macromycin, Spiratox

Assurans with Fosphenytoin

MODERATE

Medicines with composition Fosphenytoin: Fosphen, Fosentin

Assurans with Phenobarbitone

MODERATE

Medicines with composition Phenobarbitone: Shinosun, Epikon, Nytoin, Barbee, Gardenal, Fenobarb, Luminal, Beetal, Emgard, Phenotone

Assurans with Primidone

MODERATE

Medicines with composition Primidone: Mysoline

Assurans with Clarithromycin

MODERATE

Medicines with composition Clarithromycin: Clarimac, CLR, Claripax, O Clar, Clarinic, C Cin, Klarim, Klarinton, Cloff, Clavid, Mythrocin, Frank, Clarsaf, Calrcin, Clarcin, Clarital, Truclar, Claricin, Bioclar, Claribid, Klarcid, Clarie, Clarigard, Macrobid, Clamycin, Clarinova, Clarithro, Unitrocin, Clariol, Clariwin

Assurans with Roxithromycin

MODERATE

Medicines with composition Roxithromycin: Zuroxy, Roxilim, Rox Thro, Ani Rox, Enirox, Serox, Marox, Roxup, Roxiden, Adrox, P Rox, Roxro, Cidocin, Roxall, Roxipax, Throxid, Ruben, Alrox, Karoxy, Ethirox, RO, Grox, Tilide, Tikrox, Roxcol, Roximin, Roxyron, Roxin, Rxn, Uthrox, Roxicon, J Roxy, Roxiwin, Roxson, Roxipol, Roxymycin, Starox, Indarox, RXT, V Rox, Roxalgo, Roxina, Altrox, Roxirap, Viroxx, Lomin, Virrox, Turex, Roxt, Veerox, Roxiba, Entrox, Remycin, Santrox, Roxtri, Biolide, Vonmycin, Throxin, Roxica, Bythro, M Rox, Roxitin, Synrox, Othrox, Roxilox, Kexith, Roxiza, Roxel, Bio Throx, Kylrox, Hirox, Roxyvin, Roxinit, Arox, Throaid, Aqrox, Roxid, Roxilac, Vilrox, Roxeptin, Roxyrol, Q Rox, Aurox, Roxygo, Romithrax, Raxitid, Roxy, Roxikem, Roxywin, Rekthro, Xthrocin, Roxibest, Roxychem, Bactimycin, Roxipil, Roxicate, Roxikind, Throx, Roxibid, Roxith, Roxitec, G Rox, Roxywok, Roxigull, Ecrobid, Rokim, Roxon, Roxivista, Rithro, Ziroxy, Roxicard, Eroxy, Roxem, Roxinga, Roxiron, RT Cure, D Throcine, Sirox, Roxetomin, Roxicura, Roxitroy, Unorox, Actirox, Ralrox, Roxika, Respride, Roxisara, Luprex, R Oxi, Roxibest P, Roxithro, Roxipic, Roxitab, Cadithro, Roxikon, Roxivik

Assurans with Carbamazepine

MODERATE

Medicines with composition Carbamazepine: Carz, Antep, C Lep, Ametol, Setol, Carbatol, Biocarb, Arbetol, Antilep, Versizur, Carbazep, Mezocar LA, Tegrital, Majerol, Mezapin, Carbesta, Shitol, Ezapin, Mazetol, Epnil, Versitol, Zigma, Carbin, Carbacontin, Zeptol, Epilent, Acetol, Seizurone

Assurans with Phenytoin

MODERATE

Medicines with composition Phenytoin: Stoin, Marantin, Notian, Phenytoin Sodium, Phenozed, Episol, Neptoin, C-Toin, Protoin, Pna, Seztin, Atoin, Phenos, M Toin, Fentoin

Assurans with Cimetidine

MINOR

Medicines with composition Cimetidine: Acitak

Assurans with Famotidine

MINOR

Medicines with composition Famotidine: Femo, Fagene, Avifam, Pedin, Famotic, Nocid, Fadine, Famot, Acidosh, Autidine, Fudone, Famtac, Fam H2, Famocer, Topcid, Faltidin, Polyfam, Famodin, Temcid, Famit, Famonext, Famowal, Tobur, Famonit

Assurans with Nizatidine

MINOR

Medicines with composition Nizatidine: Axid

Assurans with Roxatidine

MINOR

Medicines with composition Roxatidine: Rotane

Assurans with Lafutidine

MINOR

Medicines with composition Lafutidine: Lafter, Lafudac, Lafty, Lafukem, Lafaxid, Laciloc, Lafumac, Swiftin

Assurans with Ranitidine

MINOR

Medicines with composition Ranitidine: Acigo, Rin, Ranis, Randor, No Gas, Ritin, Raniciz, Zivitec, Ranitidine, Ancid, Ranitol, Ranidip, Zantid, Rantis, Niratin, Rand, Ucidin, Asitac, Ulciran, Tostac, Radine, Acitech, Suziran, M Tin, H2A, Binitac, Osoran, Pepsidin, Tidac, Rani, Rantidine, Rancet, Peptiran, Consec, Rdin, Retiva, Kaytec, Ulcitab, Hytide RD, Rdinxt, Rintin, Taurdin, Ranial, Ranx L, Rancor, Ozotac, Zynol, Stantac, Ulcidin, Monolac

Check Assurans Injection Interactions with other drugs

Information last updated by Dr. Varun Gupta, MD Pharmacology on 5th Mar 2018.

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