Aspire Tablet XR
Prescription RequiredProduct introduction
Aspire Tablet XR is used to treat schizophrenia and mania. It works by helping to restore the balance of certain natural chemicals in the brain, which improves mood, thinking, and behavior, and reduces symptoms like hallucinations or delusions.
Aspire Tablet XR may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms. However, discontinue this medicine immediately if you experience Neuroleptic malignant syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness.
Some common side effects of this medicine include drowsiness, anxiety, increased heart rate and tremor. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.
You should be cautious if you are using this medicine as it may increase the risk of developing diabetes, so it is better to monitor glucose regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts while taking this medicine.
Uses of Aspire Tablet XR
Benefits of Aspire Tablet XR
In Mania
Mania means extremely excited or elevated mood. Aspire Tablet XR helps calm the mood and relax the nerves. This stabilises the mood and prevents the symptoms of mania from recurring again. Taking Aspire Tablet XR will ensure that you have a better social life and are able to do daily activities more comfortably.
Side effects of Aspire Tablet XR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aspire
- Abnormal involuntary movements
- Dizziness
- Injection site reactions (pain, swelling, redness)
- Nystagmus (involuntary eye movement)
- Sleepiness
- Tremors
- Cogwheel rigidity
- Nasopharyngitis (inflammation of the throat and nasal passages)
How to use Aspire Tablet XR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aspire Tablet XR may be taken with or without food.
How Aspire Tablet XR works
Aspire Tablet XR is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts and behavior.
Safety advice
Alcohol
UNSAFE
Do not drink alcohol while you are taking this medicine. Aspire Tablet XR may cause excessive drowsiness when taken with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
The safety of Aspire Tablet XR during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
CONSULT YOUR DOCTOR
Aspire Tablet XR may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving
UNSAFE
Aspire Tablet XR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Aspire Tablet XR should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Aspire Tablet XR is not recommended in patients with end-stage kidney disease.
Use of Aspire Tablet XR is not recommended in patients with end-stage kidney disease.
Liver
SAFE IF PRESCRIBED
Aspire Tablet XR is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
Limited information is available on the use of Aspire Tablet XR in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Limited information is available on the use of Aspire Tablet XR in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
What if you forget to take Aspire Tablet XR?
If you miss a dose of Aspire Tablet XR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Take it in the morning, preferably at the same time every day.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Use caution while driving or doing anything that requires concentration as Aspire Tablet XR can cause dizziness and sleepiness.
- It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly.
- Monitor your blood sugar regularly as Aspire Tablet XR can affect blood sugar levels.
- Do not stop taking Aspire Tablet XR without talking to your doctor first as it may cause a worsening of symptoms.
Fact Box
Chemical Class
Pyridopyrimidines
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Atypical Antipsychotics
Interaction with drugs
Taking Aspire with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Haloperidol with Paliperidone.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Ondansetron with Paliperidone.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Amiodarone with Paliperidone.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Escitalopram Oxalate with Paliperidone.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Iloperidone with Paliperidone.
Concomitant use may affect heart rhythm and may be fatal.
Patient concerns
FAQs
Is paliperidone the same as risperidone?
Paliperidone gets converted to risperidone in the body and thus exerts similar actions
Is Aspire Tablet XR a narcotic?
No, Aspire Tablet XR is not a narcotic
Is Aspire Tablet XR an atypical antipsychotic?
Yes, Aspire Tablet XR is an atypical antipsychotic
How is Aspire Tablet XR metabolized?
Aspire Tablet XR is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes
Does Aspire Tablet XR cause weight gain?
Yes, Aspire Tablet XR is known to cause weight gain
Does Aspire Tablet XR cause erectile dysfunction?
Aspire Tablet XR may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use
How long does Aspire Tablet XR stay in your system?
Oral Aspire Tablet XR may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Stahl SM, editor. Paliperidone. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 503-508.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1047-48.
- Paliperidone. High Wycombe, Bucks: Janssen-Cilag Ltd.; 2007 [revised 13 Sep. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
- Paliperidone. Vacaville, California: ALZA Corporation; 2006. [Accessed 25 Mar 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Paliperidone. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
- Paliperidone. High Wycombe, Bucks: Janssen-Cilag Ltd.; 2012 [revised 13 Sep. 2018]. [Accessed 25 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
- Paliperidone. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2025. [Accessed 11 Jul. 2025] (online) Available from:
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Country of origin: India
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